Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2480 - 2480
Published: Oct. 17, 2023
Photodynamic
therapy
(PDT)
has
emerged
as
a
powerful
tumor
treatment
tool
due
to
its
advantages
including
minimal
invasiveness,
high
selectivity
and
thus
dampened
side
effects.
On
the
other
side,
efficacy
of
PDT
is
severely
frustrated
by
limited
oxygen
level
in
tumors,
promoting
combination
with
therapies,
particularly
photothermal
(PTT)
for
bolstered
outcomes.
Meanwhile,
nanomedicines
that
could
respond
various
stimuli
microenvironment
(TME)
provide
tremendous
benefits
combined
phototherapy
efficient
hypoxia
relief,
tailorable
drug
release
activation,
improved
cellular
uptake
intratumoral
penetration
nanocarriers,
etc.
In
this
review,
we
will
introduce
merits
combining
PTT
PDT,
summarize
recent
important
progress
phototherapies
their
combinations
dominant
regimen,
chemotherapy
based
on
smart
sensitive
TME
focus
sophisticated
designs,
discuss
challenges
future
developments
nanomedicine-mediated
phototherapies.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 28, 2025
The
unique
physiological
structure
of
women
has
led
to
a
variety
diseases
that
have
attracted
the
attention
many
people
in
recent
years.
Disturbances
reproductive
system
microenvironment
lead
progression
various
female
tumours
and
pregnancy
disorders.
Numerous
studies
shown
epigenetic
modifications
crucially
influence
both
oogenesis
foetal
development.
m6A,
modification
at
mRNA
level,
consists
three
parts,
namely,
writers,
erasers,
readers,
which
are
involved
several
biological
functions,
such
as
nucleation
stabilisation
mRNAs,
thereby
regulating
development
diseases.
In
this
manuscript,
we
delineate
constituents
their
roles,
advancements
understanding
m6A
within
maternal–foetal
immunological
context.
addition,
summarise
mechanism
gynaecological
provide
new
perspective
for
targeting
delay
clinical
practice.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2022,
Volume and Issue:
9
Published: Jan. 11, 2022
Exosomes
are
small
nanoscale
vesicles
with
a
double-layered
lipid
membrane
structure
secreted
by
cells,
and
almost
all
types
of
cells
can
secrete
exosomes.
carry
variety
biologically
active
contents
such
as
nucleic
acids
proteins,
play
an
important
role
not
only
in
intercellular
information
exchange
signal
transduction,
but
also
various
pathophysiological
processes
the
human
body.
Surface-enhanced
Raman
Spectroscopy
(SERS)
uses
light
to
interact
nanostructured
materials
gold
silver
produce
strong
surface
plasmon
resonance
effect,
which
significantly
enhance
molecules
adsorbed
on
nanostructures
obtain
rich
fingerprint
sample
itself
or
probe
ultra-sensitivity.
The
unique
advantages
SERS,
non-invasive
high
sensitivity,
good
selectivity,
fast
analysis
speed,
low
water
interference,
make
it
promising
technology
for
life
science
clinical
testing
applications.
In
this
paper,
we
briefly
introduce
exosomes
current
main
detection
methods.
We
describe
basic
principles
SERS
progress
application
unlabeled
labeled
exosome
detection.
This
paper
summarizes
value
SERS-based
assays
early
tumor
diagnosis.
Chemistry & Biodiversity,
Journal Year:
2023,
Volume and Issue:
20(11)
Published: Sept. 18, 2023
Nanogels
represent
promising
drug
delivery
systems
in
the
biomedical
field,
designed
to
overcome
challenges
associated
with
standard
treatment
approaches.
Stimuli-responsive
nanogels,
often
referred
as
intelligent
materials,
have
garnered
significant
attention
for
their
potential
enhance
control
over
properties
such
release
and
targeting.
Furthermore,
researchers
recently
explored
application
of
nanogels
diverse
sectors
beyond
biomedicine
including
sensing
catalysts,
or
adsorbents
environmental
applications.
However,
fully
harness
practical
systems,
further
research
is
required
better
understand
pharmacokinetic
behaviour,
interactions
between
bio
distributions,
well
toxicities.
One
future
stimuli-responsive
multifunctional
use
agents
cancer
treatment,
offering
an
alternative
conventional
This
review
discusses
various
synthetic
methods
employed
developing
efficient
carriers
treatment.
The
investigations
explore,
key
aspects
multifunctionality
properties,
toxicity
concerns.
discussions
presented
herein
aim
provide
readers
a
comprehensive
understanding
smart
context
therapy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(10), P. 2480 - 2480
Published: Oct. 17, 2023
Photodynamic
therapy
(PDT)
has
emerged
as
a
powerful
tumor
treatment
tool
due
to
its
advantages
including
minimal
invasiveness,
high
selectivity
and
thus
dampened
side
effects.
On
the
other
side,
efficacy
of
PDT
is
severely
frustrated
by
limited
oxygen
level
in
tumors,
promoting
combination
with
therapies,
particularly
photothermal
(PTT)
for
bolstered
outcomes.
Meanwhile,
nanomedicines
that
could
respond
various
stimuli
microenvironment
(TME)
provide
tremendous
benefits
combined
phototherapy
efficient
hypoxia
relief,
tailorable
drug
release
activation,
improved
cellular
uptake
intratumoral
penetration
nanocarriers,
etc.
In
this
review,
we
will
introduce
merits
combining
PTT
PDT,
summarize
recent
important
progress
phototherapies
their
combinations
dominant
regimen,
chemotherapy
based
on
smart
sensitive
TME
focus
sophisticated
designs,
discuss
challenges
future
developments
nanomedicine-mediated
phototherapies.
