Optical attenuation coefficient of skin under low compression DOI

Raquel Pantojo de Souza Bachour,

Christian Tolentino Dominguez, George C. Cardoso

et al.

Journal of the Optical Society of America A, Journal Year: 2023, Volume and Issue: 40(5), P. 955 - 955

Published: March 29, 2023

In various biomedical optics therapies, knowledge of how light is absorbed or scattered by tissues crucial. Currently, it suspected that a low compression applied to the skin surface may improve delivery into tissue. However, minimum pressure needed be significantly increase penetration has not been determined. this study, we used optical coherence tomography (OCT) measure attenuation coefficient human forearm dermis in regime (<8kPa). Our results show pressures such as 4 kPa 8 are sufficient decreasing at least 1.0mm-1.

Language: Английский

Photothermal and Photodynamic Therapy of Tumors with Plasmonic Nanoparticles: Challenges and Prospects DOI Open Access
Alla B. Bucharskaya, Nikolai G. Khlebtsov, Boris N. Khlebtsov

et al.

Materials, Journal Year: 2022, Volume and Issue: 15(4), P. 1606 - 1606

Published: Feb. 21, 2022

Cancer remains one of the leading causes death in world. For a number neoplasms, efficiency conventional chemo- and radiation therapies is insufficient because drug resistance marked toxicity. Plasmonic photothermal therapy (PPT) using local hyperthermia induced by gold nanoparticles (AuNPs) has recently been extensively explored tumor treatment. However, despite attractive promises, current PPT status limited laboratory experiments, academic papers, only few preclinical studies. Unfortunately, most nanoformulations still share similar fate: great promises fair trials. This review discusses challenges prospects plasmonic nanomedicine based on photodynamic (PDT). We start with consideration fundamental principles underlying properties AuNPs to tune their plasmon resonance for desired NIR-I, NIR-2, SWIR optical windows. The basic simulation cross-sections heating under CW pulsed irradiation are discussed. Then, we consider state-of-the-art methods wet chemical synthesis popular PPPT such as silica/gold nanoshells, Au nanostars, nanorods, nanocages. efficiencies these compared, applications shortly In separate section, discuss fabrication other laser ablation liquid method. second part devoted our recent experimental results laser-activated interaction healthy tissues achievements research groups this application area. unresolved issues significant accumulation organs mononuclear phagocyte system, causing potential toxic effects nanoparticles, possibility recurrence due presence survived cells. prospective ways solving problems discussed, including developing combined antitumor PDT. conclusion summarize urgent needs PPT-based nanomedicine.

Language: Английский

Citations

45
Hybrid Nanocomposite Fabrication of Nanocatalyst with Enhanced and Stable Photocatalytic Activity DOI
Mohammad Harun‐Ur‐Rashid, Kaushik Pal, Abu Bin Imran

et al.

Topics in Catalysis, Journal Year: 2023, Volume and Issue: 67(1-4), P. 17 - 45

Published: April 4, 2023

Language: Английский

Citations

41
THz biosensing applications for clinical laboratories: Bottlenecks and strategies DOI Creative Commons

Huiyan Tian,

Guorong Huang,

Fengxin Xie

et al.

TrAC Trends in Analytical Chemistry, Journal Year: 2023, Volume and Issue: 163, P. 117057 - 117057

Published: April 13, 2023

Rapid and sensitive detection of various cells biomolecules in a nondestructive manner is great importance for clinical laboratories. Terahertz (THz) spectrometric approaches are exceptionally suitable biomedical biosensing due to their nature molecular fingerprinting capability. However, some bottlenecks THz biosensing, including strong absorption waves by water, low sensitivity poor spatial resolution/THz wave confinement, still exist, which require cross-disciplinary collaboration between optics science overcome. In this review, we summarize the recent sensing strategies that have made significant breakthroughs solving above problems, thus paving way laboratory applications, involving metamaterials, microfluidics, optical clearing agents, fibers, algorithms typical combination modes. Despite numerous promising results, many applications addressed current studies not ready adoption. This review also discusses remaining hurdles corresponding near future. We hope will see accreditation potential value laboratories clinicians patients through interdisciplinary cooperation among researchers biology, materials science.

Language: Английский

Citations

26
Antimicrobial carbon materials-based quantum dots: From synthesis strategies to antibacterial properties for diagnostic and therapeutic applications in wound healing DOI
Iman Zare,

Shima Zahed Nasab,

Amid Rahi

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216211 - 216211

Published: Sept. 18, 2024

Language: Английский

Citations

12
Inorganic Nanomaterials Used in Anti-Cancer Therapies:Further Developments DOI Creative Commons
Olga Długosz, Wiktoria Matyjasik,

Gabriela Hodacka

et al.

Nanomaterials, Journal Year: 2023, Volume and Issue: 13(6), P. 1130 - 1130

Published: March 22, 2023

In this article, we provide an overview of the progress scientists working to improve quality life cancer patients. Among known methods, treatment methods focusing on synergistic action nanoparticles and nanocomposites have been proposed described. The application composite systems will allow precise delivery therapeutic agents cells without systemic toxicity. nanosystems described could be used as a high-efficiency photothermal therapy system by exploiting properties individual nanoparticle components, including their magnetic, photothermal, complex, bioactive properties. By combining advantages it is possible obtain product that would effective in treatment. use nanomaterials produce both drug carriers those active substances with direct anti-cancer effect has extensively discussed. section, attention paid metallic nanoparticles, metal oxides, magnetic others. complex compounds biomedicine also A group showing significant potential therapies are natural compounds, which

Language: Английский

Citations

18
Non-invasive transcutaneous influenza immunization using vaccine-loaded vaterite particles DOI
Yulia I. Svenskaya, Ekaterina V. Lengert, Yana V. Tarakanchikova

et al.

Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(17), P. 3860 - 3870

Published: Jan. 1, 2023

A novel protocol for topical influenza immunization is reported. CaCO 3 carriers are used to deliver vaccine into hair follicles aiming target perifollicular antigen presenting cells. This approach represents a promising alternative injections.

Language: Английский

Citations

14
Near-infrared-II deep tissue fluorescence microscopy and application DOI
Pengfei Liu, Rong Zhao, Hongwei Li

et al.

Nano Research, Journal Year: 2022, Volume and Issue: 16(1), P. 692 - 714

Published: Sept. 27, 2022

Language: Английский

Citations

20
Exploiting Benefits of Vaterite Metastability to Design Degradable Systems for Biomedical Applications DOI Creative Commons
Yulia I. Svenskaya, Тatiana Pallaeva

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(11), P. 2574 - 2574

Published: Nov. 2, 2023

The widespread application of calcium carbonate is determined by its high availability in nature and simplicity synthesis laboratory conditions. Moreover, possesses highly attractive physicochemical properties that make it suitable for a wide range biomedical applications. This review provides conclusive analysis the results on using tunable vaterite metastability development biodegradable drug delivery systems therapeutic vehicles with controlled sustained release incorporated cargo. manuscript highlights nuances recrystallization to non-porous calcite, dissolution at acidic pH, biodegradation vivo conditions control over these processes. outlines main benefits instability liberation encapsulated molecules natural synthetic polymeric materials purposes.

Language: Английский

Citations

11
Portable Acoustic Holographic Optical Waveguide Device for Phototherapy DOI

R. Wang,

Qibo Lin, Zhaoxi Li

et al.

ACS Photonics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

Photodynamic therapy and photothermal have emerged as indispensable modalities to treat diseases. However, their efficacy is hindered by the substantial light scattering within tissues, preventing transmission effectively targeted lesion sites. Various existing devices aimed at mitigating typically exhibit invasiveness complexity. In this work, we propose an approach that utilizes a portable acoustic holographic optical waveguide device mitigate manipulating refractive index tissues. This manipulation allows in situ modulation of scattered light, thereby promoting concentration photon energy. We demonstrated can medium through simulation imaging experiments. Second, both photodynamic experiments enhance rate temperature rise singlet oxygen (1O2) generation, respectively. It foreseeable versatility overcoming augment outcomes phototherapy, offering noninvasive, portable, robust method.

Language: Английский

Citations

0
Enhanced Fluorescence Imaging of Implants Based on Polyester Copolymers in Combination With MRI DOI Open Access
Victoria V. Zherdeva,

Astemir R. Likhov,

Ulugbek Saidvaliev

et al.

Journal of Biophotonics, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

ABSTRACT Nowadays, many biodegradable materials are offered for biomedical applications, but there only a few in vivo methods their detection and monitoring. In this work, implants based on polyester copolymers were labeled with indocyanine green (ICG) fluorescence imaging combination tissue optical clearing (TOC) magnetic resonance (MRI). The results include vitro degradation modeling followed by of copolymer samples that subcutaneously implanted BALB/c mice. TOC 70% glycerol has been demonstrated to significantly improve sample visualization. efficiency parameter Q the variability effects correlating timing follow‐up postimplantation period. It shown nonhealing wounds, peri‐implantation inflammation, or fibrosis, confirmed MRI, affect effectiveness range from = −30% 70%.

Language: Английский

Citations

0