Nano Research, Journal Year: 2022, Volume and Issue: 16(2), P. 2749 - 2761
Published: Oct. 20, 2022
Language: Английский
Chemical Society Reviews, Journal Year: 2024, Volume and Issue: 53(6), P. 2932 - 2971
Published: Jan. 1, 2024
Silver and gold nanoparticles have found extensive biomedical applications due to their strong localized surface plasmon resonance (LSPR) intriguing plasmonic properties. This review article focuses on the correlation among particle geometry, properties applications. It discusses how shape size are tailored
Language: Английский
Citations
116
Cancers, Journal Year: 2024, Volume and Issue: 16(6), P. 1156 - 1156
Published: March 14, 2024
Hyperthermia (HT) is an anti-cancer therapy commonly used with radio and chemotherapies based on applying heat (39-45 °C) to inhibit tumor growth. However, controlling towards tumors not normal tissues challenging. Therefore, nanoparticles (NPs) are in HT apply only induce DNA damage the expression of shock proteins, which eventually result apoptosis. The aim this review article summarize recent advancements use magnetic NPs locally increase temperature promote cell death. In addition, development nanocarriers as NP-based drug delivery systems discussed. Finally, efficacy combined chemotherapy, radiotherapy, gene therapy, photothermal immunotherapy explored.
Language: Английский
Citations
41
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(2), P. 117 - 117
Published: Jan. 15, 2025
Monte Carlo (MC) simulations have become important in advancing nanoparticle (NP)-based applications for cancer imaging and therapy. This review explores the critical role of MC modeling complex biological interactions, optimizing NP designs, enhancing precision therapeutic diagnostic strategies. Key findings highlight ability to predict bio-distribution, radiation dosimetry, treatment efficacy, providing a robust framework addressing stochastic nature systems. Despite their contributions, face challenges such as complexity, computational demands, scarcity reliable nanoscale data. However, emerging technologies, including hybrid approaches, high-performance computing, quantum simulation, are poised overcome these limitations. Furthermore, novel advancements FLASH radiotherapy, multifunctional NPs, patient-specific data integration expanding capabilities clinical relevance simulations. topical underscores transformative potential bridging fundamental research translation. By facilitating personalized nanomedicine streamlining regulatory trial processes, offer pathway toward more effective, tailored, accessible treatments. The continued evolution simulation techniques, driven by interdisciplinary collaboration technological innovation, ensures that will remain at forefront nanomedicine’s progress.
Language: Английский
Citations
2
Deleted Journal, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 23, 2025
Gold-coated nanoparticles have garnered significant attention in recent years due to their exceptional thermal stability and distinct optical properties. This paper investigates the characteristics of various nanoparticles, including Silica, Gold, Silica using Mie theory, Gan's effective medium approach. Plasmonic been extensively studied for medical applications across scientific fields. Their surface plasmon resonance remarkable ability absorb scatter light revolutionized diagnosis, treatment, assessment numerous diseases, particularly cancer. One valuable these linked plasmonic properties, is use photothermal therapy cancer treatment. Nanoparticle-based phototherapy has emerged as one most treatment methods years, owing its high efficiency destroying cancerous tumors while minimizing side effects.
Language: Английский
Citations
2
Metabolites, Journal Year: 2025, Volume and Issue: 15(3), P. 201 - 201
Published: March 13, 2025
Background: Tumor cells engage in continuous self-replication by utilizing a large number of resources and capabilities, typically within an aberrant metabolic regulatory network to meet their own demands. This dysregulation leads the formation tumor microenvironment (TME) most solid tumors. Nanomedicines, due unique physicochemical properties, can achieve passive targeting certain tumors through enhanced permeability retention (EPR) effect, or active deliberate design optimization, resulting accumulation TME. The use nanomedicines target critical pathways holds significant promise. However, requires careful selection relevant drugs materials, taking into account multiple factors. traditional trial-and-error process is relatively inefficient. Artificial intelligence (AI) integrate big data evaluate delivery efficiency nanomedicines, thereby assisting nanodrugs. Methods: We have conducted detailed review key papers from databases, such as ScienceDirect, Scopus, Wiley, Web Science, PubMed, focusing on reprogramming, mechanisms action development metabolism, application AI empowering nanomedicines. integrated content present current status research metabolism potential future directions this field. Results: Nanomedicines possess excellent TME which be utilized disrupt cells, including glycolysis, lipid amino acid nucleotide metabolism. disruption selective killing disturbance Extensive has demonstrated that AI-driven methodologies revolutionized nanomedicine development, while concurrently enabling precise identification molecular regulators involved oncogenic reprogramming pathways, catalyzing transformative innovations targeted cancer therapeutics. Conclusions: great Additionally, will accelerate discovery metabolism-related targets, empower optimization help minimize toxicity, providing new paradigm for development.
Language: Английский
Citations
2
Critical Reviews in Therapeutic Drug Carrier Systems, Journal Year: 2024, Volume and Issue: 41(6), P. 1 - 56
Published: Jan. 1, 2024
Cancer is among the leading causes of mortality and morbidity in world. Metallic nanoparticles, especially gold nanoparticles (AuNPs) have emerged to be attractive systems circumvent associated adverse effects. By virtue their unique properties tunable size, shape, composition, optical properties, biocompatibility, minimal toxicity, multivalency, fluorescence-luminescence property surface plasmon resonance; AuNPs potential used as drug delivery systems. It vital ensure that reaches target site action for selective kill cancer cells without harm healthy cells. These can easily functionalized with a wide array ligands like peptides, oligonucleotides, polymers, carbohydrates active targeting specific reduced systemic been in-vestigated carriers gene delivery, or photothermal therapy, diagnosis based on radiation spectroscopy. They theranostic approach overall management superior benefit risk features. In this review, we discussed synthesis different (nanorods, spherical hollow AuNPs), functionalization strategies applications biomedical domain. Various research studies clinical trials application therapeutics are highlighted.
Language: Английский
Citations
10
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: 14(9), P. 2417 - 2432
Published: Jan. 19, 2024
Language: Английский
Citations
10
Carbohydrate Polymers, Journal Year: 2022, Volume and Issue: 301, P. 120311 - 120311
Published: Nov. 8, 2022
Language: Английский
Citations
34
International Journal of Nanomedicine, Journal Year: 2023, Volume and Issue: Volume 18, P. 1695 - 1708
Published: March 1, 2023
Abstract: Graphene-family nanomaterials (GFNs) possess mechanical stiffness, optical properties, and biocompatibility making them promising materials for biomedical applications. However, to realize the potential of graphene in biomedicine, it must overcome several challenges that arise when enters body’s circulatory system. Current research focuses on development tumor-targeting devices using graphene, but GFNs accumulated different tissues cells through pathways, which can cause toxic reactions leading cell apoptosis body dysfunction amount exceeds a certain limit. In addition, as foreign substance, induce complex inflammatory with immune factors, potentially enhancing or impairing function. This review discusses applications effects human function, biotoxicity materials. Keywords: family nanomaterials, biomedical, biocompatibility, limitation, system
Language: Английский
Citations
19
International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(13), P. 10875 - 10875
Published: June 29, 2023
The rapid rise in research and development following the discovery of photodynamic therapy to establish novel photosensitizers overcome limitations technology soon after its clinical translation has given a few significant milestones. These include several generations photosensitizers, widening scope applications, leveraging offerings nanotechnology for greater efficacy, selectivity disease over host tissue cells, advent combination therapies with other similarly minimally invasive therapeutic technologies, use stimulus-responsive delivery targeting, penetration depth activation energy. Brought together, all these milestones have contributed enhancement what is still arguably technology. Yet major applications remain firmly located neoplasms, from where most new innovations appear launch areas, such as microbial, fungal, viral, acne, wet age-related macular degeneration, atherosclerosis, psoriasis, environmental sanitization, pest control, dermatology. Three main value propositions combinations synergistic additive relatively low emergence resistance targeted high-precision therapy. Combinations established methods chemotherapy radiotherapy demonstrated mop-up surgery promise enhance top three tools. From published vitro preclinical studies, trials postclinical case seven become prominent interests because they are potentially easily applied, showing enhanced rapidly translating clinic. chemotherapy, photothermal therapy, magnetic hyperthermia, cold plasma sonodynamic immunotherapy, radiotherapy. Photochemical internalization critical mechanism some combinations.
Language: Английский
Citations
19