Exploration,
Journal Year:
2023,
Volume and Issue:
4(3)
Published: Dec. 7, 2023
Abstract
Atherosclerosis,
a
chronic
disease
associated
with
metabolism,
poses
significant
risk
to
human
well‐being.
Currently,
existing
treatments
for
atherosclerosis
lack
sufficient
efficiency,
while
the
utilization
of
surface‐modified
nanoparticles
holds
potential
deliver
highly
effective
therapeutic
outcomes.
These
can
target
and
bind
specific
receptors
that
are
abnormally
over‐expressed
in
atherosclerotic
conditions.
This
paper
reviews
recent
research
(2018–present)
advances
various
ligand‐modified
nanoparticle
systems
targeting
by
specifically
signature
molecules
hope
precise
treatment
at
molecular
level
concludes
discussion
challenges
prospects
this
field.
The
intention
review
is
inspire
novel
concepts
design
advancement
targeted
nanomedicines
tailored
atherosclerosis.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Aug. 7, 2023
Cancer
remains
a
highly
lethal
disease
in
the
world.
Currently,
either
conventional
cancer
therapies
or
modern
immunotherapies
are
non-tumor-targeted
therapeutic
approaches
that
cannot
accurately
distinguish
malignant
cells
from
healthy
ones,
giving
rise
to
multiple
undesired
side
effects.
Recent
advances
nanotechnology,
accompanied
by
our
growing
understanding
of
biology
and
nano-bio
interactions,
have
led
development
series
nanocarriers,
which
aim
improve
efficacy
while
reducing
off-target
toxicity
encapsulated
anticancer
agents
through
tumor
tissue-,
cell-,
organelle-specific
targeting.
However,
vast
majority
nanocarriers
do
not
possess
hierarchical
targeting
capability,
their
indices
often
compromised
poor
accumulation,
inefficient
cellular
internalization,
inaccurate
subcellular
localization.
This
Review
outlines
current
prospective
strategies
design
organelle-targeted
nanomedicines,
highlights
latest
progress
technologies
can
dynamically
integrate
these
three
different
stages
static
maximize
outcomes.
Finally,
we
briefly
discuss
challenges
future
opportunities
for
clinical
translation
nanomedicines.
MedComm,
Journal Year:
2023,
Volume and Issue:
4(4)
Published: July 14, 2023
Nanoparticles
(NPs)
have
become
one
of
the
most
popular
objects
scientific
study
during
past
decades.
However,
despite
wealth
reports,
still
there
is
a
gap,
particularly
in
health
toxicology
studies,
underlying
mechanisms,
and
related
evaluation
models
to
deeply
understanding
NPs
risk
effects.
In
this
review,
we
first
present
comprehensive
landscape
applications
on
health,
especially
addressing
role
medical
diagnosis,
therapy.
Then,
toxicity
systems
introduced.
We
describe
detail
effects
various
systems,
including
respiratory,
nervous,
endocrine,
immune,
reproductive
carcinogenicity
NPs.
Furthermore,
unravels
mechanisms
ROS
accumulation,
mitochondrial
damage,
inflammatory
reaction,
apoptosis,
DNA
cell
cycle,
epigenetic
regulation.
addition,
classical
such
as
lines
mice
emerging
3D
organoids
used
for
evaluating
or
are
both
Overall,
review
presents
critical
summary
state
NPs,
giving
readers
more
better
remedy
key
gaps
knowledge
techniques.
Journal of Molecular Liquids,
Journal Year:
2023,
Volume and Issue:
395, P. 123888 - 123888
Published: Dec. 27, 2023
Efficient
drug
delivery
systems
(DDSs)
play
a
pivotal
role
in
ensuring
pharmaceuticals'
targeted
and
effective
administration.
However,
the
intricate
interplay
between
formulations
poses
challenges
their
design
optimization.
Simulations
have
emerged
as
indispensable
tools
for
comprehending
these
interactions
enhancing
DDS
performance
to
address
this
complexity.
This
comprehensive
review
explores
latest
advancements
simulation
techniques
provides
detailed
analysis.
The
encompasses
various
methodologies,
including
molecular
dynamics
(MD),
Monte
Carlo
(MC),
finite
element
analysis
(FEA),
computational
fluid
(CFD),
density
functional
theory
(DFT),
machine
learning
(ML),
dissipative
particle
(DPD).
These
are
critically
examined
context
of
research.
article
presents
illustrative
case
studies
involving
liposomal,
polymer-based,
nano-particulate,
implantable
DDSs,
demonstrating
influential
simulations
optimizing
systems.
Furthermore,
addresses
advantages
limitations
It
also
identifies
future
directions
research
development,
such
integrating
multiple
techniques,
refining
validating
models
greater
accuracy,
overcoming
limitations,
exploring
applications
personalized
medicine
innovative
DDSs.
employing
like
MD,
MC,
FEA,
CFD,
DFT,
ML,
DPD
offer
crucial
insights
into
behaviour,
aiding
Despite
advantages,
rapid
cost-effective
screening,
require
validation
addressing
limitations.
Future
should
focus
on
models,
enhance
outcomes.
paper
underscores
contribution
emphasizing
providing
valuable
facilitating
development
optimization
ultimately
patient
As
we
continue
explore
impact
advancing
discovery
improving
DDSs
is
expected
be
profound.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(15)
Published: Jan. 17, 2024
Abstract
Nanotechnology
profoundly
affects
the
advancement
of
medicine.
Limitations
in
diagnosing
and
treating
cancer
chronic
diseases
promote
growth
nanomedicine.
However,
there
are
very
few
analytical
descriptive
studies
regarding
trajectory
nanomedicine,
key
research
powers,
present
landscape,
focal
investigative
points,
future
outlooks.
Herein,
articles
reviews
published
Science
Citation
Index
Expanded
Web
Core
Collection
from
first
January
2000
to
18th
July
2023
analyzed.
a
bibliometric
visualization
publication
trends,
countries/regions,
institutions,
journals,
categories,
themes,
references,
keywords
is
produced
elaborated.
Nanomedicine‐related
academic
output
increasing
since
COVID‐19
pandemic,
solidifying
uneven
global
distribution
performance.
While
China
leads
terms
quantity
has
numerous
highly
productive
USA
advantages
impact,
commercialization,
industrial
value.
Nanomedicine
integrates
with
other
disciplines,
establishing
interdisciplinary
platforms,
which
drug
delivery
nanoparticles
remain
points.
Current
focuses
on
integrating
nanomedicine
cell
ferroptosis
induction
immunotherapy.
The
keyword
“burst
testing”
identifies
promising
directions,
including
immunogenic
death,
chemodynamic
therapy,
tumor
microenvironment,
immunotherapy,
extracellular
vesicles.
prospects,
major
challenges,
barriers
addressing
these
directions
discussed.
