Smart nanoparticles for cancer therapy

Signal Transduction and Targeted Therapy, Journal Year: 2023, Volume and Issue: 8(1)

Published: Nov. 3, 2023

Abstract Smart nanoparticles, which can respond to biological cues or be guided by them, are emerging as a promising drug delivery platform for precise cancer treatment. The field of oncology, nanotechnology, and biomedicine has witnessed rapid progress, leading innovative developments in smart nanoparticles safer more effective therapy. In this review, we will highlight recent advancements including polymeric dendrimers, micelles, liposomes, protein cell membrane mesoporous silica gold iron oxide quantum dots, carbon nanotubes, black phosphorus, MOF others. We focus on their classification, structures, synthesis, intelligent features. These possess the ability various external internal stimuli, such enzymes, pH, temperature, optics, magnetism, making them systems. Additionally, review explore latest studies tumor targeting functionalizing surfaces with tumor-specific ligands like antibodies, peptides, transferrin, folic acid. also summarize different types options, small molecules, proteins, nucleic acids, even living cells, potential use While is promising, acknowledge challenges clinical prospects associated use. Finally, propose blueprint that involves artificial intelligence-powered treatment applications. By harnessing aims usher new era personalized therapy, providing patients individualized options.

Language: Английский

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Emerging Applications of Nanotechnology in Healthcare and Medicine

Molecules, Journal Year: 2023, Volume and Issue: 28(18), P. 6624 - 6624

Published: Sept. 14, 2023

Knowing the beneficial aspects of nanomedicine, scientists are trying to harness applications nanotechnology in diagnosis, treatment, and prevention diseases. There also potential uses designing medical tools processes for new generation scientists. The main objective conducting this research review is gather widespread nanomedicine under one heading highlight standard practices field. Comprehensive has been conducted incorporate latest data related medicine therapeutics derived from acknowledged scientific platforms. Nanotechnology used conduct sensitive procedures. showing successful fields diagnostics, disease regenerative medicine, gene therapy, dentistry, oncology, aesthetics industry, drug delivery, therapeutics. A thorough association cooperation between physicians, clinicians, researchers, technologies will bring forward a future where there more calculated, outlined, technically programed field nanomedicine. Advances being made overcome challenges associated with application due pathophysiological basis This highlights multipronged how proving health industry. need minimize health, environmental, ethical concerns linked nanotechnology.

Language: Английский

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Stimuli-activatable nanomedicine meets cancer theranostics

Theranostics, Journal Year: 2023, Volume and Issue: 13(15), P. 5386 - 5417

Published: Jan. 1, 2023

Stimuli-activatable strategies prevail in the design of nanomedicine for cancer theranostics.Upon exposure to endogenous/exogenous stimuli, stimuli-activatable could be self-assembled, disassembled, or functionally activated improve its biosafety and diagnostic/therapeutic potency.A myriad tumor-specific features, including a low pH, high redox level, overexpressed enzymes, along with exogenous physical stimulation sources (light, ultrasound, magnet, radiation) have been considered nano-medicinal products.Recently, novel stimuli explored elegant designs emerged nanomedicine.In addition, multi-functional theranostic has employed imaging-guided image-assisted antitumor therapy.In this review, we rationalize development clinical pressing needs.Stimuli-activatable self-assembly, disassembly functional activation approaches developing realize better efficacy are elaborated state-of-the-art advances their structural detailed.A reflection, status, future perspectives provided.

Language: Английский

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Biomarker-driven molecular imaging probes in radiotherapy

Theranostics, Journal Year: 2024, Volume and Issue: 14(10), P. 4127 - 4146

Published: Jan. 1, 2024

Biomarker-driven molecular imaging has emerged as an integral part of cancer precision radiotherapy. The use probes, including nanoprobes, have been explored in radiotherapy to precisely and noninvasively monitor spatiotemporal distribution biomarkers, potentially revealing tumor-killing mechanisms therapy-induced adverse effects during radiation treatment.

Language: Английский

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pH-Responsive wound dressings: advances and prospects

Nanoscale Horizons, Journal Year: 2023, Volume and Issue: 8(4), P. 422 - 440

Published: Jan. 1, 2023

This review focuses on the design strategies and advanced functions of pH-responsive wound dressings, makes a systematic discussion challenges future development trends in this field.

Language: Английский

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Impairing Tumor Metabolic Plasticity via a Stable Metal‐Phenolic‐Based Polymeric Nanomedicine to Suppress Colorectal Cancer

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(23)

Published: March 14, 2023

Targeting metabolic vulnerability of tumor cells is a promising anticancer strategy. However, the therapeutic efficacy existing metabolism-regulating agents often compromised due to tolerance resulting from plasticity, as well their poor bioavailability and tumor-targetability. Inspired by inhibitive effect N-ethylmaleimide on mitochondrial function, dendronized-polymer-functionalized metal-phenolic nanomedicine (pOEG-b-D-SH@NP) encapsulating maleimide-modified doxorubicin (Mal-DOX) developed enable improvement in overall delivery efficiency inhibition metabolism via multiple pathways. It observed that Mal-DOX its derived induces energy depletion CT26 colorectal cancer more efficiently than doxorubicin, shifts balance programmed cell death apoptosis toward necroptosis. Notably, pOEG-b-D-SH@NP simultaneously inhibits cellular oxidative phosphorylation glycolysis, thus potently suppressing growth peritoneal intestinal metastasis mouse models. Overall, study provides dendronized-polymer-derived nanoplatform for treatment cancers through impairing plasticity.

Language: Английский

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Enzyme-triggered deep tumor penetration of a dual-drug nanomedicine enables an enhanced cancer combination therapy

Bioactive Materials, Journal Year: 2023, Volume and Issue: 26, P. 102 - 115

Published: Feb. 25, 2023

Cancer cells could be eradicated by promoting generation of excessive intracellular reactive oxygen species (ROS) via emerging nanomedicines. However, tumor heterogeneity and poor penetration nanomedicines often lead to diverse levels ROS production in the site, at a low level promote cell growth, thus diminishing therapeutic effect these Herein, we construct an amphiphilic block polymer-dendron conjugate-derived nanomedicine (Lap@pOEGMA-b-p(GFLG-Dendron-Ppa), GFLG-DP/Lap NPs) that incorporates photosensitizer, Pyropheophorbide (Ppa), for therapy Lapatinib (Lap) molecular targeted therapy. Lap, epidermal growth factor receptor (EGFR) inhibitor plays role inhibiting proliferation, is hypothesized synergize with effectively killing cancer cells. Our results suggest enzyme-sensitive polymeric conjugate, pOEGMA-b-p(GFLG-Dendron-Ppa) (GFLG-DP), releases response cathepsin B (CTSB) after entering tissue. Dendritic-Ppa has strong adsorption capacity membranes, which promotes efficient long-term retention. Lap can also efficiently delivered internal play its due increased vesicle activity. Laser irradiation Ppa-containing sufficient inducing apoptosis. Meanwhile, inhibits proliferation remaining viable even deep regions, generating significant synergistic anti-tumor effect. This novel strategy extended development membrane lipid-based therapies combat tumors.

Language: Английский

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Design of experiments in the optimization of nanoparticle-based drug delivery systems

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 358, P. 398 - 419

Published: May 12, 2023

Language: Английский

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Bio-Inspired Nanomaterials for Micro/Nanodevices: A New Era in Biomedical Applications

Micromachines, Journal Year: 2023, Volume and Issue: 14(9), P. 1786 - 1786

Published: Sept. 18, 2023

Exploring bio-inspired nanomaterials (BINMs) and incorporating them into micro/nanodevices represent a significant development in biomedical applications. Nanomaterials, engineered to imitate biological structures processes, exhibit distinctive attributes such as exceptional biocompatibility, multifunctionality, unparalleled versatility. The utilization of BINMs demonstrates potential diverse domains micro/nanodevices, encompassing biosensors, targeted drug delivery systems, advanced tissue engineering constructs. This article thoroughly examines the various BINMs, including those originating from proteins, DNA, biomimetic polymers. Significant attention is directed toward these entities subsequent ramifications that arise. review explores biomimicry’s structure–function correlations. Synthesis mosaics include bioprocesses, biomolecules, natural structures. These nanomaterials’ interfaces use functionalization geometric adaptations, transforming delivery, nanobiosensing, organ-on-chip cancer-on-chip models, wound healing dressing mats, antimicrobial surfaces. It provides an in-depth analysis existing challenges proposes prospective strategies improve efficiency, performance, reliability devices. Furthermore, this study offers forward-thinking viewpoint highlighting avenues for future exploration advancement. objective effectively utilize maximize application progression thereby propelling rapidly developing field its promising future.

Language: Английский

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A Review of Advanced Multifunctional Magnetic Nanostructures for Cancer Diagnosis and Therapy Integrated into an Artificial Intelligence Approach

Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 868 - 868

Published: March 7, 2023

The new era of nanomedicine offers significant opportunities for cancer diagnostics and treatment. Magnetic nanoplatforms could be highly effective tools diagnosis treatment in the future. Due to their tunable morphologies superior properties, multifunctional magnetic nanomaterials hybrid nanostructures can designed as specific carriers drugs, imaging agents, theranostics. Multifunctional are promising theranostic agents due ability diagnose combine therapies. This review provides a comprehensive overview development advanced combining optical providing photoresponsive platforms medical applications. Moreover, this discusses various innovative developments using nanostructures, including drug delivery, treatment, tumor-specific ligands that deliver chemotherapeutics or hormonal resonance imaging, tissue engineering. Additionally, artificial intelligence (AI) used optimize material properties based on predicted interactions with cell membranes, vasculature, biological fluid, immune system enhance effectiveness therapeutic agents. Furthermore, an AI approaches assess practical utility Finally, presents current knowledge perspectives systems models.

Language: Английский

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