Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 70 - 96
Published: Aug. 29, 2023
Language: Английский
Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114683 - 114683
Published: Jan. 17, 2023
Language: Английский
Citations
18
Advanced Materials, Journal Year: 2023, Volume and Issue: 35(42)
Published: Aug. 25, 2023
Developing a drug delivery platform that possesses universal loading capacity to meet various requirements of cancer treatment is challenging yet interesting task. Herein, self-assembled gelatin/silk fibroin composite (GSC) particle based system developed via microphase separation followed by desolvation process. Thanks its preassembled stage, this GSC suitable for varying types drugs. The process fix drugs inside rapidly and densify the structure, thereby achieving efficient providing comprehensive protection loaded Actually, size brand-new non-pore dependent can be easily adjusted from 100 nm 20 µm fit different scenarios. This work selects with 3 diameter as inhaled platform, which shows an excellent transmucosal penetration lung retention ability. Additionally, MMP-9 sensitive degradation property enhances targeted efficiency reduces side effects. Intestinally, self-amplify regulation innate immunity reverse cancerous microenvironment into antitumor niche, significantly improving therapeutic effect study provides new direction develop next-generation cancer.
Language: Английский
Citations
17
Advanced Materials, Journal Year: 2022, Volume and Issue: 35(7)
Published: Nov. 25, 2022
Abstract Myeloid cells are abundant, create a highly immunosuppressive environment in glioblastoma (GBM), and thus contribute to poor immunotherapy responses. Based on the hypothesis that small molecules can be used stimulate myeloid elicit anti‐tumor effector functions, synthetic nanoparticle approach is developed deliver dual NF‐kB pathway‐inducing agents into these via systemic administration. Synthetic, cyclodextrin‐adjuvant nanoconstructs (CANDI) with high affinity for tumor‐associated dually loaded TLR7 8 (Toll‐like receptor, 7 8) agonist (R848) cIAP (cellular inhibitor of apoptosis protein) (LCL‐161) activate cells. Here CANDI shown to: i) readily enter GBM tumor microenvironment (TME) accumulate at concentrations, ii) taken up by cells, iii) potently synergize payloads compared monotherapy, iv) v) fosters “hot” TME levels T vi) controls growth murine as mono‐ combination therapies anti‐PD1. Multi‐pathway targeted stimulation platform efficiently drive immunity GBM.
Language: Английский
Citations
28
Materials & Design, Journal Year: 2024, Volume and Issue: 238, P. 112731 - 112731
Published: Feb. 1, 2024
Pyroptosis, which is a novel form of immunogenic cell death, plays vital role in antitumor therapy. Zirconium-based metal–organic frameworks (Zr-MOFs) have been applied various treatments. However, the intrinsic these pyroptosis has yet to be determined. Here, Zr-MOF-based nanosystem (DOX@Zr-MOF) was constructed by loading Zr-MOF nanoparticles with chemotherapeutic drug doxorubicin (DOX) synergistically trigger cancer pyroptosis. We found that DOX@Zr-MOF rapidly triggered via activation canonical caspase-3/gasdermin E (GSDME)-dependent pathway, resulting significant suppression CT26 colon tumor growth vitro and vivo. Furthermore, significantly enhanced systemic immune response reprogramming immunosuppressive microenvironment. In addition, combination programmed death-1 (PD-1) immunotherapy strongly improved efficacy tumors. Overall, this work provides promising strategy for pyroptosis-mediated anticancer treatment, may efficiently improve checkpoint blockade-related immunotherapy.
Language: Английский
Citations
5
International Journal of Pharmaceutics, Journal Year: 2023, Volume and Issue: 639, P. 122970 - 122970
Published: April 19, 2023
Language: Английский
Citations
12
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125356 - 125356
Published: Feb. 1, 2025
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137647 - 137647
Published: Feb. 17, 2025
Microplastic particles (MP) ubiquitously occur in all environmental compartments where they interact with biomolecules, forming an eco-corona on their surfaces. The affects the surface properties of MP and consequently how cells. Proteins, integral component within eco-corona, may serve as a ligand driving interaction membrane receptors. To date, it is not known, whether eco-coronae originating from different media differ proteinaceous compositions these differently We show that protein composition formed freshwater (FW) salt water (SW) are distinct each other. did observe adhesion strengths between coated However, internalization efficiency underlying mechanisms significantly differed FW- SW eco-coronae. By inhibiting actin-driven receptor-mediated processes using Cytochalasin-D, Amiloride, Amantadine, we FW microplastic predominantly become internalized via phagocytosis, while macropinocytosis more important for particles. Overall, our findings origin coatings factors cellular This highlights relevance adverse effects environmentally relevant cells organisms.
Language: Английский
Citations
0
ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 17, 2025
The effectiveness of immunotherapy in killing melanoma is hindered by a T-cell deficiency and the lack tumor immunogenicity. Consequently, there an urgent need for platform that can further activate immune system boost response host to tumors. Compared with monotherapy, combination therapy shows promise improving treatment efficacy rates. This study introduces pioneering use rationally designed active targeting nanoplatform bind axitinib, paclitaxel, verteporfin human serum albumin (APV@HSA NPs). APV@HSA NPs have demonstrated capability induce dual-induced apoptosis cells through chemo- photodynamic effects, while also enhancing immunogenic cell death promoting dendritic maturation. Additionally, promoted production CD8+ T memory inhibited vascular endothelial growth factor via facilitating infiltration effector optimizing chemo-photodynamic immunotherapy. Hence, amplified chemo-photodynamic-immunological nanomedicines excellent biocompatibility been redesigned inhibit microenvironment combat primary lung metastasis. approach initiates series responses, presenting promising therapeutic strategy melanoma.
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113595 - 113595
Published: March 6, 2025
In receptor-mediated transcytosis (RMT) of large therapeutics across the blood-brain barrier (BBB), construct - a macromolecule or larger carrier with therapeutic payload binds protein on brain capillary endothelial cells (BCEC), internalization and release into parenchyma. The construct's into, trafficking from, but also possible entrapment within BCEC are affected by its engineered properties whose optimization has helped derive insights transport mechanisms at BCEC. Furthermore, advances in multi-omics, as well large-scale screening directed evolution campaigns have identify new targets for RMT this perspective, I raise reflect some fundamental questions one can arrive comparing BBB-targeted constructs different target proteins. These concern underlying, transcytosis-promoting factors that constructs' appears to converge on, precise role proteins RMT, through which these may mediate trafficking, tentative criteria selection Based considerations propose several scenarios strategies interfere more efficient internalization, endosomal network toward abluminal membrane, from BCEC, both smaller macromolecules carriers.
Language: Английский
Citations
0
International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125470 - 125470
Published: March 1, 2025
Language: Английский
Citations
0