ACS Nano,
Journal Year:
2024,
Volume and Issue:
18(11), P. 7769 - 7795
Published: Feb. 29, 2024
Tumor-associated
macrophages
(TAMs)
play
pivotal
roles
in
tumor
development.
As
primary
contents
of
environment
(TME),
TAMs
secrete
inflammation-related
substances
to
regulate
tumoral
occurrence
and
There
are
two
kinds
TAMs:
the
tumoricidal
M1-like
protumoral
M2-like
TAMs.
Reprogramming
from
immunosuppressive
M2
immunocompetent
M1
phenotype
is
considered
a
feasible
way
improve
immunotherapeutic
efficiency.
Notably,
nanomaterials
show
great
potential
for
biomedical
fields
due
their
controllable
structures
properties.
many
types
that
exhibit
regulatory
activities
TAMs'
reprogramming.
In
this
review,
recent
progress
nanomaterials-involved
reprogramming
comprehensively
discussed.
The
various
strategies
summarized
introduced.
Additionally,
challenges
perspectives
efficient
therapy
discussed,
aiming
provide
inspiration
regulator
design
promote
development
TAMs-mediated
immunotherapy.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(11), P. 2617 - 2617
Published: Nov. 11, 2023
Photodynamic
therapy
(PDT)
is
an
approved
therapeutic
procedure
that
exerts
cytotoxic
activity
towards
tumor
cells
by
activating
photosensitizers
(PSs)
with
light
exposure
to
produce
reactive
oxygen
species
(ROS).
Compared
traditional
treatment
strategies
such
as
surgery,
chemotherapy,
and
radiation
therapy,
PDT
not
only
kills
the
primary
tumors,
but
also
effectively
suppresses
metastatic
tumors
immune
response.
However,
anti-tumor
effects
induced
are
influenced
several
factors,
including
localization
of
PSs
in
cells,
concentration,
fluence
rate
light,
integrity
function.
In
this
review,
we
systematically
summarize
influence
factors
mediated
PDT.
Furthermore,
update
on
combination
other
immunotherapy
provided.
Finally,
future
directions
challenges
immunity
discussed.
Pharmaceutical Development and Technology,
Journal Year:
2024,
Volume and Issue:
29(3), P. 221 - 235
Published: Feb. 26, 2024
Photodynamic
therapy
(PDT)
has
emerged
as
a
promising
non
invasive
therapeutic
approach
for
cancer
treatment,
offering
unique
advantages
over
conventional
treatments.
The
combination
of
light
activation
and
photosensitizing
agents
allows
targeted
localized
destruction
cells,
reducing
damage
to
surrounding
healthy
tissues.
In
recent
years,
the
integration
nanoparticles
with
PDT
garnered
significant
attention
due
their
potential
enhance
outcomes.
This
review
article
aims
provide
comprehensive
overview
current
state-of-the-art
in
utilizing
photodynamic
treatment.
We
summarized
various
nanoparticle-based
approaches,
properties,
implications
optimizing
efficacy,
discussed
challenges
prospects
field.
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 10129 - 10144
Published: Oct. 1, 2024
Immunotherapy
is
a
promising
cancer
treatment
because
of
its
ability
to
sustainably
enhance
the
natural
immune
response.
However,
effects
multiple
immunotherapies,
including
ICIs,
are
limited
by
resistance
these
agents,
immune-related
adverse
events,
and
lack
reasonable
therapeutic
targets
available
at
right
time
place.
The
tumor
microenvironment
(TME),
which
features
tumor-associated
macrophages
(TAMs),
plays
significant
role
in
owing
hypoxic
blood
vessels,
resulting
evasion.
To
immunotherapy,
photodynamic
therapy
(PDT)
can
increase
innate
adaptive
responses
through
immunogenic
cell
death
(ICD)
improve
TME.
Traditional
photosensitizers
(PSs)
also
include
novel
nanomedicines
precisely
target
cells
or
TAMs.
Here,
we
reviewed
summarized
current
strategies
possible
influencing
factors
for
photoimmunotherapy.
Frontiers in Pharmacology,
Journal Year:
2024,
Volume and Issue:
15
Published: April 10, 2024
Cancer
stem
cells
(CSC)
are
the
leading
cause
of
failure
anti-tumor
treatments.
These
aggressive
cancer
preserved
and
sustained
by
adjacent
forming
a
specialized
microenvironment,
termed
niche,
among
which
tumor-associated
macrophages
(TAMs)
critical
players.
The
cycle
tricarboxylic
acids,
fatty
acid
oxidation
path,
electron
transport
chain
have
been
proven
to
play
central
roles
in
development
maintenance
CSCs
TAMs.
By
improving
their
oxidative
metabolism,
able
extract
more
energy
from
nutrients,
allows
them
survive
nutritionally
defective
environments.
Because
mitochondria
crucial
bioenergetic
hubs
sites
these
metabolic
pathways,
major
hopes
posed
for
drugs
targeting
mitochondria.
A
wide
range
medications
mitochondria,
complexes,
or
enzymes
currently
investigated
phase
1
2
clinical
trials
against
hard-to-treat
tumors.
This
review
article
aims
highlight
recent
literature
on
adaptations
supporting
macrophages.
focus
is
provided
resistance
dormancy
behaviors
that
give
selection
advantage
quiescence
capacity
particularly
hostile
microenvironments
role
TAMs
attitudes.
also
describes
medicaments
demonstrated
robust
ability
disrupt
core
metabolism
preclinical
studies
being
tested
trials.
Tumor
hypoxia
and
elevated
intracellular
glutathione
(GSH)
levels
significantly
compromise
the
effectiveness
of
photodynamic
therapy
(PDT)
in
treating
melanoma.
In
this
study,
we
synthesized
positively
charged
nanoparticles
through
a
self-assembly
method,
incorporating
photosensitizer
verteporfin
(VER),
mitochondrial
respiratory
inhibitor
atovaquone
(ATO),
Fe
