Nanotechnology Reviews, Journal Year: 2023, Volume and Issue: 12(1)
Published: Jan. 1, 2023
Graphical abstract
Language: Английский
Acta Pharmaceutica Sinica B, Journal Year: 2023, Volume and Issue: 13(11), P. 4391 - 4416
Published: May 20, 2023
Owing to the inherent shortcomings of traditional therapeutic drugs in terms inadequate efficacy and toxicity clinical treatment, nanomedicine designs have received widespread attention with significantly improved reduced non-target side effects. Nanomedicines hold tremendous theranostic potential for treating, monitoring, diagnosing, controlling various diseases are attracting an unfathomable amount input research resources. Against backdrop exponentially growing number publications, it is imperative help audience get a panorama image activities field nanomedicines. Herein, this review elaborates on development trends nanomedicines, emerging nanocarriers, vivo fate safety their extensive applications. Moreover, challenges obstacles hindering translation nanomedicines also discussed. The elaboration aspects may enlighten readers set route future endeavors.
Language: Английский
Citations
86
Materials Today Advances, Journal Year: 2022, Volume and Issue: 16, P. 100299 - 100299
Published: Sept. 20, 2022
Language: Английский
Citations
78
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 772 - 772
Published: Feb. 26, 2023
Numerous drugs have emerged to treat various diseases, such as COVID-19, cancer, and protect human health. Approximately 40% of them are lipophilic used for treating diseases through delivery routes, including skin absorption, oral administration, injection. However, a low solubility in the body, drug systems (DDSs) being actively developed increase bioavailability. Liposomes, micro-sponges, polymer-based nanoparticles been proposed DDS carriers drugs. their instability, cytotoxicity, lack targeting ability limit commercialization. Lipid (LNPs) fewer side effects, excellent biocompatibility, high physical stability. LNPs considered efficient vehicles owing lipid-based internal structure. In addition, recent LNP studies suggest that bioavailability can be increased surface modifications, PEGylation, chitosan, surfactant protein coating. Thus, combinations an abundant utilization potential fields DDSs carrying this review, functions efficiencies types modifications optimize discussed.
Language: Английский
Citations
75
Nature Reviews Drug Discovery, Journal Year: 2024, Volume and Issue: 23(4), P. 281 - 300
Published: Jan. 23, 2024
Language: Английский
Citations
63
Pharmaceutics, Journal Year: 2023, Volume and Issue: 15(3), P. 774 - 774
Published: Feb. 26, 2023
Nanomedicine is a branch of medicine using nanotechnology to prevent and treat diseases. Nanotechnology represents one the most effective approaches in elevating drug‘s treatment efficacy reducing toxicity by improving drug solubility, altering biodistribution, controlling release. The development materials has brought profound revolution medicine, significantly affecting various major diseases such as cancer, injection, cardiovascular experienced explosive growth past few years. Although clinical transition nanomedicine not very satisfactory, traditional drugs still occupy dominant position formulation development, but increasingly active have adopted nanoscale forms limit side effects improve efficacy. review summarized approved nanomedicine, its indications, properties commonly used nanocarriers nanotechnology.
Language: Английский
Citations
62
Advanced Materials, Journal Year: 2023, Volume and Issue: unknown
Published: Oct. 4, 2023
Abstract Lipid‐based nanoparticles (LBNPs) are currently the most promising vehicles for nucleic acid drug (NAD) delivery. Although their clinical applications have achieved success, NAD delivery efficiency and safety still unsatisfactory, which are, to a large extent, due existence of multi‐level physiological barriers in vivo. It is important elucidate interactions between these LBNPs, will guide more rational design efficient with low adverse effects facilitate broader therapeutics. This review describes obstacles challenges biological at systemic, organ, sub‐organ, cellular, subcellular levels. The strategies overcome comprehensively reviewed, mainly including physically/chemically engineering LBNPs directly modifying by auxiliary treatments. Then potentials successful translation preclinical studies into clinic discussed. In end, forward look on manipulating protein corona (PC) addressed, may pull off trick overcoming those significantly improve efficacy LBNP‐based NADs
Language: Английский
Citations
53
Vaccines, Journal Year: 2024, Volume and Issue: 12(2), P. 186 - 186
Published: Feb. 12, 2024
In recent years, lipid nanoparticles (LNPs) have attracted extensive attention in tumor immunotherapy. Targeting immune cells cancer therapy has become a strategy of great research interest. mRNA vaccines are potential choice for immunotherapy, due to their ability directly encode antigen proteins and stimulate strong response. However, the mode delivery lack stability key issues limiting its application. LNPs an excellent carrier, structural biocompatibility make them effective means delivering specific targets. This study summarizes progress LNP carrier-assisted targeted controlled release immunity. The role improving stability, immunogenicity, targeting is discussed. review aims systematically summarize latest immunity provide new ideas strategies as well more treatment plans patients.
Language: Английский
Citations
53
NPG Asia Materials, Journal Year: 2023, Volume and Issue: 15(1)
Published: March 31, 2023
Abstract Nanoarchitectonics describes the integration of nanotechnology with other fields as a postnanotechnology concept that elevates it to material science. Based on this fundamental principle, we address pore-engineered nanoarchitectonics application targets for cancer therapy by combining basic descriptions and exemplifying applications in review. The initial two sections briefly summarize basics according classification based (i) porosity (ii) composition. Afterward, main application-oriented section—designing mesoporous therapy—is presented. Various types drug delivery systems, including nanoparticles nanocarriers, endogenous stimuli-responsive delivery, exogenous targeted are described. Importantly, clinical translation materials is further discussed. Mesoporous unique offer network cavities vehicles nanocarriers. Regarding developments allow be broadly used settings, there several challenges should solved their application. From perspective, tremendous processes development materials.
Language: Английский
Citations
44
Nano Letters, Journal Year: 2024, Volume and Issue: 24(5), P. 1477 - 1486
Published: Jan. 23, 2024
Lipid nanoparticle (LNP)-mediated nucleic acid therapies, including mRNA protein replacement and gene editing hold great potential in treating neurological disorders neurodegeneration, brain cancer, stroke. However, delivering LNPs across the blood-brain barrier (BBB) after systemic administration remains underexplored. In this work, we engineered a high-throughput screening transwell platform for BBB (HTS-BBB), specifically optimized LNPs. Unlike most assays, which only assess transport an endothelial monolayer, HTS-BBB simultaneously measures LNP transfection of cells themselves. We then use to screen library 14 made with structurally diverse ionizable lipids demonstrate it is predictive
Language: Английский
Citations
27
Advanced Drug Delivery Reviews, Journal Year: 2024, Volume and Issue: 209, P. 115304 - 115304
Published: April 9, 2024
Language: Английский
Citations
20