Biomedicines,
Journal Year:
2024,
Volume and Issue:
12(10), P. 2302 - 2302
Published: Oct. 10, 2024
The
bloodstream
and
the
central
nervous
system
(CNS)
are
separated
by
blood–brain
barrier
(BBB),
an
intricate
network
of
blood
vessels.
Its
main
role
is
to
regulate
environment
within
brain.
primary
obstacle
for
drugs
enter
CNS
low
permeability
BBB,
presenting
a
significant
hurdle
in
treating
brain
disorders.
In
recent
years,
advancements
have
been
made
researching
methods
breach
BBB.
However,
understanding
how
penetrate
BBB
essential
drug
delivery
techniques.
Therefore,
this
article
reviews
mechanisms
breaking
through
as
well
current
research
progress
on
mechanism.
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 22, 2024
Abstract
The
blood‐brain
barrier
(BBB)
poses
a
significant
challenge
in
delivering
therapeutic
agents
for
brain
diseases
due
to
its
high
selectivity
against
foreign
substances.
This
limitation
greatly
hampers
the
effectiveness
of
conventional
chemotherapeutic
drugs
treating
cancers.
In
response,
lipid‐based
nanoparticles
(LNPs)
have
emerged
as
promising
approach,
offering
opportunities
targeted
drug
delivery
by
conjugating
targeting
ligands
onto
their
surface.
review
provides
comprehensive
overview
recent
advancements
utilizing
LNPs
traverse
BBB
enhanced
transport
bioactive
compounds
into
brain,
specifically
cancer
treatments.
Beginning
with
an
exploration
biological
structure
and
functions
tumor
(BBTB),
highlights
advantages
presented
LNPs.
Subsequently,
it
delves
strategies
surface
modification
enhance
improve
efficacy
treatment.
Finally,
offers
insights
future
prospects
designing
next
generation
herein
aims
contribute
ongoing
efforts
overcoming
challenges
associated
penetration,
ultimately
advancing
other
neurological
disorders.
Advanced Biology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 14, 2025
Abstract
Diseases
of
the
nervous
system
are
recognized
as
second
leading
cause
death
worldwide.
The
global
prevalence
neurological
diseases,
such
Huntington's
disease,
Alzheimer's
and
Parkinson's
disease
has
seen
a
significant
rise
due
to
increasing
proportion
aging
population.
discovery
clustered
regularly
interspaced
short
palindromic
repeats
(CRISPR)
genome
editing
technique
paved
way
for
universal
diseases
treatment.
However,
finding
safe
effective
method
deliver
CRISPR
gene‐editing
tools
remains
main
challenge
therapies
in
vivo.
Adeno‐associated
virus
(AAV)
is
currently
one
most
commonly
used
vector
systems,
but
some
issues
remain
unresolved,
including
capsid
immunogenicity,
off‐target
mutations,
potential
genotoxicity.
To
address
these
concerns,
researchers
actively
encouraging
development
new
delivery
like
virus‐like
particles
nanoparticles.
These
novel
systems
have
enhance
targeting
efficiency,
thereby
offering
possible
solutions
current
challenges.
This
article
reviews
vectors
disorders
treatment
explores
overcome
limitations
systems.
Additionally,
strategies
highlighted
valuable
studying
challenges
opportunities
that
present.
Journal of Controlled Release,
Journal Year:
2024,
Volume and Issue:
376, P. 678 - 700
Published: Oct. 28, 2024
There
is
a
clinical
need
to
develop
lipid
nanoparticles
(LNPs)
deliver
congenital
therapies
the
fetus
during
pregnancy.
The
aim
of
these
restore
normal
fetal
development
and
prevent
irreversible
conditions
after
birth.
As
first
step,
LNPs
be
optimized
for
transplacental
transport,
safety
on
placental
barrier
organs
transfection
efficiency.
We
developed
characterized
library
varying
compositions
used
machine
learning
(ML)
models
delineate
determinants
LNP
size
zeta
potential.
Utilizing
different
in
vitro
with
help
Random
Forest
algorithm,
we
could
identify
top
features
driving
percentage
transport
kinetics
at
24
h,
out
total
18
input
represented
by
41
formulations
48
experiments.
further
evaluated
safety,
cell
uptake,
efficiency
trophoblasts
lung
fibroblasts.
To
ensure
integrity
following
screened
using
high-throughput
integrated
transport-transfection
model.
Finally,
assessed
toxicity
tracheal
occlusion
explant
showed
little
no
cells.
Immunoglobin
G
(IgG)
orientation
surface
LNPs,
PEGylated
lipids,
ionizable
lipids
had
significant
effects
transport.
algorithm
identified
kinetics.
Zeta
potential
emerged
features.
Building
ML
model
results,
new
optimize
leading
622
%
increase
h
versus
control
formulation.
induce
preferential
siRNA
lung,
cationic
lipid-to-siRNA
ratio.
Studying
an
fibroblasts
strong
correlation
between
transfection.
appeared
safe
ex
vivo
lungs
as
indicated
insignificant
changes
apoptosis
(Caspase-3)
proliferation
(Ki67)
markers.
In
conclusion,
have
formulation
that
safe,
high
Our
research
findings
represent
important
step
toward
establishing
effectiveness
gene
delivery
organs.
Nano Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 17, 2024
Systemic
delivery
of
large
nucleic
acids,
such
as
mRNA,
to
the
brain
remains
challenging
in
part
due
blood-brain
barrier
(BBB)
and
tendency
vehicles
accumulate
liver.
Here,
we
design
a
peptide-functionalized
lipid
nanoparticle
(LNP)
platform
for
targeted
mRNA
brain.
We
utilize
click
chemistry
functionalize
LNPs
with
peptides
that
target
receptors
overexpressed
on
endothelial
cells
neurons,
namely
RVG29,
T7,
AP2,
mApoE
peptides.
evaluate
effect
LNP
targeting
neuronal
cell
transfection
vitro,
investigating
factors
serum
protein
adsorption,
intracellular
trafficking,
transcytosis,
exosome
secretion.
Finally,
show
peptide
functionalization
enhances
mouse
reduces
hepatic
after
systemic
administration.
Specifically,
RVG29
improved
vivo,
establishing
its
potential
nonviral
delivering
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 6757 - 6776
Published: July 1, 2024
Abstract:
Glioma
is
a
primary
malignant
tumor
in
the
central
nervous
system.
In
recent
years,
treatment
of
glioma
has
developed
rapidly,
but
overall
survival
patients
not
significantly
improved.
Due
to
presence
blood–brain
barrier
and
intracranial
barrier,
many
drugs
with
good
effects
cure
vitro
cannot
be
accurately
transported
corresponding
lesions.
order
enable
anti-tumor
overcome
barriers
target
glioma,
nanodrug
delivery
systems
have
emerged
recently.
It
gratifying
that
liposomes,
as
multifunctional
carrier,
which
can
compatible
hydrophilic
hydrophobic
drugs,
easily
functionalized
by
various
targeted
ligands,
biodegradable,
hypoimmunogenic
vivo,
become
quality
choice
solve
intractable
problem
medication.
Therefore,
we
focused
on
liposome
system,
summarized
its
current
research
progress
glioma.
Hopefully,
this
review
may
provide
new
ideas
for
development
liposome-based
nanomaterials
clinical
Keywords:
blood‒brain
nanomaterials,
liposome,
nanoparticle
drug
system
Materials Today Bio,
Journal Year:
2024,
Volume and Issue:
26, P. 101101 - 101101
Published: May 29, 2024
Messenger
ribonucleic
acid
(mRNA)
has
emerged
as
a
promising
molecular
preventive
and
therapeutic
approach
that
opens
new
avenues
for
healthcare.
Although
the
use
of
delivery
systems,
especially
lipid
nanoparticles
(LNPs),
greatly
improves
efficiency
stability
mRNA,
mRNA
tends
to
accumulate
in
liver
hardly
penetrates
physiological
barriers
reach
target
site
after
intravenous
injection.
Hence,
rational
design
targeting
strategies
aimed
at
directing
specific
tissues
cells
remains
an
enormous
challenge
therapy.
High-throughput
screening
(HTS)
is
cutting-edge
targeted
technique
capable
synthesizing
chemical
compound
libraries
large-scale
experiments
validate
system.
In
this
review,
we
firstly
provide
overview
conventional
low-throughput
strategies.
Then
latest
advancements
HTS
techniques
delivery,
encompassing
optimizing
structures
vehicles
developing
surface
ligands,
well
applications
extrahepatic
systemic
diseases
are
comprehensively
summarized.
Moreover,
illustrate
selection
administration
routes
delivery.
Finally,
challenges
field
potential
solutions
tackle
them
proposed,
offering
insights
future
development
toward
Frontiers in Oncology,
Journal Year:
2024,
Volume and Issue:
14
Published: Sept. 27, 2024
Originally
devised
for
cancer
control,
mRNA
vaccines
have
risen
to
the
forefront
of
medicine
as
effective
instruments
control
infectious
disease,
notably
their
pivotal
role
in
combating
COVID-19
pandemic.
This
review
focuses
on
fundamental
aspects
development
vaccines,
e.g.,
tumor
antigens,
vector
design,
and
precise
delivery
methodologies,
–
highlighting
key
technological
advances.
The
recent,
promising
success
personalized
against
pancreatic
melanoma
illustrates
potential
value
other
intractable,
immunologically
resistant,
solid
tumors,
such
glioblastoma,
well
synergies
with
a
combinatorial,
immunotherapeutic
approach.
impact
progress
human
cancer,
including
head
neck
bladder
are
reviewed,
lessons
learned
from
first-in-human
CAR-T
cell,
DNA
dendritic
cell
targeting
glioblastoma.
Going
forward,
roadmap
is
provided
transformative
advance
immunotherapy,
particular
focus
opportunities
challenges
current
landscape
glioblastoma
immunotherapy
gene
therapy
reviewed
an
eye
combinatorial
approaches
harnessing
RNA
science.
Preliminary
preclinical
clinical
data
supports
concept
that
could
be
viable,
novel
approach
prolong
survival
patients
