Development of Polymethine Dyes for NIR‐II Fluorescence Imaging and Therapy

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(16)

Published: March 5, 2024

Fluorescence imaging in the second near-infrared window (NIR-II) is burgeoning because of its higher fidelity monitoring physiological and pathological processes than clinical visible/the fluorescence imaging. Notably, heavily dependent on agents. So far, indocyanine green, one polymethine dyes, with good biocompatibility renal clearance only dye approved by Food Drug Administration, but it shows relatively low NIR-II brightness. Importantly, tremendous efforts are devoted to synthesizing dyes for preclinically clinically. They have shown feasibility customization structure properties fulfill various needs therapy. Herein, a timely update special focus molecular design strategies fluorescent, photoacoustic, multimodal imaging, offered. Furthermore, progress sensing biomarkers even reporting drug release illustrated. Moreover, imaging-guided therapies summarized regarding chemo-, photothermal, photodynamic, approaches. In addition, artificial intelligence pointed out potential expedite development. This comprehensive review will inspire interest among wide audience offer handbook people an dyes.

Language: Английский

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Liposomes as Immunotherapeutic Carriers: A Game-Changer in Cancer Therapy

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106847 - 106847

Published: March 1, 2025

Language: Английский

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Gene and Photothermal Combination Therapy: Principle, Materials, and Amplified Anticancer Intervention

Small, Journal Year: 2023, Volume and Issue: 20(6)

Published: Sept. 29, 2023

Gene therapy (GT) and photothermal (PTT) have emerged as promising alternatives to chemotherapy radiotherapy for cancer treatment, offering noninvasiveness reduced side effects. However, their efficacy standalone treatments is limited. GT exhibits slow response rates, while PTT confined local tumor ablation. The convergence of PTT, known GT-PTT, facilitated by gene nanocarriers, has attracted considerable attention across various disciplines. In this integrated approach, reciprocates sensitizing cellular heat, benefits improving translocation, unpacking, expression. Consequently, integration presents a unique opportunity with rapid improved effectiveness. Extensive efforts over the past few years been dedicated development resulting in notable achievements progress from laboratory potential clinical applications. This comprehensive review outlines recent advances including synergistic mechanisms, material systems, imaging-guided therapy, anticancer It also explores challenges future prospects nascent field. By presenting innovative ideas insights into implementation GT-PTT enhanced aims inspire further area research.

Language: Английский

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Unravelling the potential of mitochondria-targeted liposomes for enhanced cancer treatment

Drug Discovery Today, Journal Year: 2023, Volume and Issue: 29(1), P. 103819 - 103819

Published: Nov. 7, 2023

Language: Английский

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Emerging Chemodynamic Nanotherapeutics for Cancer Treatment

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(22)

Published: May 16, 2024

Abstract Chemodynamic therapy (CDT) has emerged as a transformative paradigm in the realm of reactive oxygen species ‐mediated cancer therapies, exhibiting its potential sophisticated strategy for precise and effective tumor treatment. CDT primarily relies on metal ions hydrogen peroxide to initiate Fenton or Fenton‐like reactions, generating cytotoxic hydroxyl radicals. Its notable advantages treatment are demonstrated, including specificity, autonomy from external triggers, favorable side‐effect profile. Recent advancements nanomedicine devoted enhancing CDT, promising comprehensive optimization efficacy. This review systematically elucidates cutting‐edge achievements chemodynamic nanotherapeutics, exploring strategies enhanced improved microenvironment modulation, regulation energy metabolism. Moreover, detailed analysis diverse CDT‐mediated combination therapies is provided. Finally, concludes with discussion prospects intrinsic challenges application nanotherapeutics domain

Language: Английский

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Inhalable Nano Formulation of Cabazitaxel: A Comparative Study with Intravenous Route

Macromolecular Bioscience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 30, 2025

Abstract Chemotherapy is generally given by intravenous (IV) administration which provides higher bioavailability than other systemic routes. However, in the case of lung cancer, pulmonary (INH) route choice for inhalable formulations. In study, biochemical and histological parameters Cabazitaxel (CBZ) free (2 mg kg −1 ) nanoparticle (NP) CBZ equivalent) formulations are investigated after IV INH rats. The nanoformulation obtained using PEGylated polystyrene (PEG‐PST) nanoparticles PISA. While a nose head‐only device used administration, jugular vein as route. Blood samples (blank, 24 h, 48 h) collected via carotid artery cannulas without handling metabolism cages. According to parameters, formulation applied or shows toxicity. On hand, showed no signs toxicity both Higher longer retention observed inhaled nanoformulation. Histological analysis alveolar macrophage migration due enhanced retention. Results that nanotechnology defense system gave advantage end up with an nanomedicine cancer.

Language: Английский

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Functional Materials for Subcellular Targeting Strategies in Cancer Therapy: Progress and Prospects

Advanced Materials, Journal Year: 2023, Volume and Issue: unknown

Published: Sept. 4, 2023

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment. However, tumor therapy still faces challenges due to the intrinsic heterogeneity of cancer, genomic instability, formation an immunosuppressive microenvironment. Functional materials possess unique biological properties such as long circulation times, tumor-specific targeting, immunomodulation. The combination functional with natural substances nanotechnology has led development smart biomaterials multiple functions, high biocompatibilities, negligible immunogenicities, which can be used for precise Recently, subcellular structure-targeting received particular attention various biomedical applications including diagnosis, sensing, imaging tumors drug delivery. Subcellular organelle-targeting precisely accumulate therapeutic agents organelles, considerably reduce threshold dosages agents, minimize drug-related side effects. This review provides a systematic comprehensive overview research organelle-targeted based on nanomaterials. Moreover, it explains prospects precision oncology. will serve excellent cutting-edge guide researchers field therapy.

Language: Английский

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Polymer-based drug delivery systems under investigation for enzyme replacement and other therapies of lysosomal storage disorders

Advanced Drug Delivery Reviews, Journal Year: 2023, Volume and Issue: 197, P. 114683 - 114683

Published: Jan. 17, 2023

Language: Английский

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A biomimetic camouflaged metal organic framework for enhanced siRNA delivery in the tumor environment

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(17), P. 4080 - 4096

Published: Jan. 1, 2024

An illustrative depiction highlighting the targeted drug delivery mechanism by bio-functionalized camouflaged MOF nanocarriers that enhances precision targeting diseased cells and minimizing side effects.

Language: Английский

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Beyond Nanoparticle‐Based Intracellular Drug Delivery: Cytosol/Organelle‐Targeted Drug Release and Therapeutic Synergism

Macromolecular Bioscience, Journal Year: 2024, Volume and Issue: 24(7)

Published: March 16, 2024

Nanoparticle (NP)-based drug delivery systems are conceived to solve poor water-solubility and chemical/physical instability, their purpose expanded target specific sites for maximizing therapeutic effects minimizing unwanted events of payloads. Targeted also narrowed from organs/tissues cells cytosol/organelles. Beyond site targeting, the particular release payloads at is growing in importance. This review overviews various issues general strategies during multiple steps, preparation drug-loaded NPs In particular, this focuses on current "first" "later" drugs cytosol or organelles interest using stimuli sites. Recognizing distinguishing presence/absence differences concentration/level/activity one place those another applied stimuli-triggered via bond cleavage nanostructural transition. addition, future directions understanding intracellular balance counter-stimuli demonstrated synergize released stimuli-sensitive NPs.

Language: Английский

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