Compartmentalizing Donor–Acceptor Stenhouse Adducts for Structure–Property Relationship Analysis DOI Creative Commons

Cesar A. Reyes,

Alexander Karr,

Chloe A. Ramsperger

et al.

Journal of the American Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 27, 2024

The development of photoswitches that absorb low energy light is notable interest due to the growing demand for smart materials and therapeutics necessitating benign stimuli. Donor–acceptor Stenhouse adducts (DASAs) are molecular respond in visible near-infrared spectrum. As a result their modular assembly, DASAs can be modified at donor, acceptor, triene, backbone heteroatom compartments tuning optical photoswitching properties. This Perspective focuses on electronic steric contributions each compartment how they influence photophysical properties through adjustment isomerization energetic landscape. An emphasis current synthetic strategies limitations highlights opportunities DASA architecture, thus property expansion.

Language: Английский

Small molecular cyanine dyes for phototheranostics DOI

Jiuhui Zhang,

Wenjun Wang, Jinjun Shao

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 516, P. 215986 - 215986

Published: June 2, 2024

Language: Английский

Citations

21
Biomedical applications of NIR-II organic small molecule fluorescent probes in different organs DOI
Lizhen Xu, Qian Zhang, Xin Wang

et al.

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 519, P. 216122 - 216122

Published: Aug. 6, 2024

Language: Английский

Citations

17
Biomolecule-based engineered nanoparticles for Cancer Theranostics DOI

Narayanan Parthasarathy,

Ramar Thangam, Babu Rithisa

et al.

Coordination Chemistry Reviews, Journal Year: 2025, Volume and Issue: 530, P. 216489 - 216489

Published: Feb. 3, 2025

Language: Английский

Citations

1
“Crossbreeding” NIR‐II flavchromene for PSMA‐positive prostate cancer detection and image‐guided surgery DOI Creative Commons
Jialiang Huang,

Yongkang Yao,

Liao Zhang

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: 2(3)

Published: July 4, 2024

Abstract Prostate‐specific membrane antigen (PSMA) is known to be overexpressed in prostate cancer (PCa). The development of precise and rapid imaging technologies monitor PSMA crucial for early diagnosis therapy. Fluorescence the second near‐infrared window (NIR‐II) has emerged as a powerful tool real‐time tracking vivo visualization, offering high sensitivity resolution. However, there lack stable, bright easy‐to‐implement NIR‐II fluorescent probes targeting. Herein, we presented PSMA‐targeting probe FC‐PSMA based on π‐conjugated crossbreeding dyed strategy that affords stability, large extinction coefficient, good brightness. As demonstrated, displayed fluorescence quantum yield fetal bovine serum (FBS). Following intravenous injection FC‐PSMA, tumor‐to‐normal ratio intensity steadily increased over time, reaching peak at 48 h (tumor‐to‐leg = 12.16 ± 0.90). This advancement enables identification PC through imaging, facilitating high‐performance guidance resection surgery.

Language: Английский

Citations

7
Homo‐Dyad with Outer Hydration Layer Approach for Developing NIR‐II Chromophore of High Stability and Water‐Solubility as Injectable and Sprayable Optical Probe DOI

Zunpan She,

Rong Li, Fang Zeng

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(19)

Published: April 8, 2024

Dyes with extended conjugate structures are the focus of extensive design and synthesis efforts, aiming to confer unique improved optical electronic properties. Such advancements render these dyes applicable across a wide spectrum uses, ranging from second-window near-infrared (NIR-II) bioimaging organic photovoltaics. Nevertheless, inherent benefits long conjugation often accompanied by persistent challenges like aggregation, fluorescence quenching, absorption blueshift, low stability poor water solubility. Herein, structural strategy termed "homo-dyad outer hydration layer" is introduced address problems, tailored for development imaging probes exhibiting absorption/emission wavelengths. This approach involves bringing two heptamethine cyanines together through flexible linker, forming homo-dyad structure, while strategically attaching four polyethylene glycol (PEG9) chains terminal heterocycles. imparts excellent solubility, biocompatibility, enhanced chemical, photo-, spectral dyes. Utilizing this strategy, biomarker-activatable probe (HD-FL-4PEG9-N) NIR-II fluorescent 3D multispectral optoacoustic tomography developed, its effectiveness in disease visualization. It can not only serve as an injectable acute kidney injury due high but also sprayable bacterial-infected wounds.

Language: Английский

Citations

6
Recent Advances in Indocyanine Green-Based Probes for NIR-II Fluorescence Imaging and Therapy DOI Creative Commons
Dehong Hu,

Menglei Zha,

Hairong Zheng

et al.

Research, Journal Year: 2024, Volume and Issue: 8

Published: Dec. 27, 2024

Fluorescence imaging, a highly sensitive molecular imaging modality, is being increasingly integrated into clinical practice. Imaging within the second near-infrared biological window (NIR-II; 1,000 to 1,700 nm), also referred as shortwave infrared, has received substantial attention because of its markedly reduced autofluorescence, deeper tissue penetration, and enhanced spatiotemporal resolution compared traditional (NIR) imaging. Indocyanine green (ICG), US Food Drug Administration-approved NIR fluorophore, long been used in applications, including blood vessel angiography, vascular perfusion monitoring, tumor detection. Recent advancements NIR-II technology have revitalized interest ICG, revealing extended tail fluorescence beyond nm reaffirming potential clinically translatable fluorophore for vivo theranostic applications diagnosing various diseases. This review emphasizes notable advances use ICG derivatives image-guided therapy from both fundamental perspectives. We provide concise conclusion discuss challenges future opportunities with using approved fluorophores.

Language: Английский

Citations

4
The Medical Basis for the Photoluminescence of Indocyanine Green DOI Creative Commons
Wiktoria Mytych, Dorota Bartusik‐Aebisher, David Aebisher

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 888 - 888

Published: Feb. 14, 2025

Indocyanine green (ICG), a near-infrared (NIR) fluorescent dye with unique photoluminescent properties, is helpful tool in many medical applications. ICG produces fluorescence when excited by NIR light, enabling accurate tissue visualization and real-time imaging. This study investigates the fundamental processes behind ICG's photoluminescence as well its present possible applications treatments diagnostics. Fluorescence-guided surgery (FGS) has been transformed capacity to visualize tumors, highlight blood flow, facilitate lymphatic mapping, all of which have improved surgical accuracy patient outcomes. Furthermore, being studied for new therapeutic approaches, like photothermal therapy, light can activate target destroy cancer cells. We go over benefits drawbacks qualities contexts, current studies that focus on improving effectiveness, security, adaptability. More precise disease detection, monitoring, tailored therapy options across variety specialties are made ongoing advancement ICG-based imaging methods therapies. In main part our work, we strive take into account latest reports; therefore, used clinical articles going back 2020. However, sake theoretical part, oldest article us from 1995.

Language: Английский

Citations

0
GSH‐Responsive Semiconducting Polymer as a Nanotheranostic Platform for NIR‐II Imaging‐Guided Chemo‐Photothermal Therapy DOI Open Access

Ben Wang,

Yu‐Jing Zhang,

Yinlin Ji

et al.

Macromolecular Rapid Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Abstract The development of multifunctional nanotheranostic platforms with stimuli‐responsive capabilities holds significant potential for enhancing cancer diagnosis and treatment. Herein, a glutathione (GSH)‐responsive semiconducting polymer (SP) system, SP/DOX‐SS‐PEG nanoparticles (NPs), is presented, designed combined near‐infrared II (NIR‐II) fluorescence imaging (FI) chemo‐photothermal therapy. amphiphilic SP (SP‐SS‐PEG) synthesized through multi‐step reaction sequence, including Suzuki coupling, amidation, thiol‐disulfide exchange reactions, subsequently encapsulates the anticancer drug doxorubicin (DOX) self‐assembly, resulting in formation GSH‐responsive NPs. These NPs exhibit high photothermal stability GSH‐triggered DOX release. In vitro studies demonstrate that display enhanced cellular uptake robust cytotoxicity against 4T1 cells under 808 nm laser irradiation. Upon intravenous injection tumor‐bearing mice, NIR‐II FI reveals efficient tumor accumulation prolonged retention vivo anti‐tumor efficacy indicate irradiation achieve most inhibition growth, minimal systemic toxicity. Taken together, these findings highlight promising as platform precision theranostics, integrating imaging, release, dual

Language: Английский

Citations

0
The latest developments of near-infrared fluorescent probes from NIR-I to NIR-II for bioimaging DOI Open Access

Yuzuka Kuronuma,

Reiko Watanabe, Yuki Hiruta

et al.

Analytical Sciences, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 28, 2025

Near-infrared I (NIR-I: 650–950 nm) fluorescence imaging is a powerful tool for deep-tissue biological imaging, addressing the limitations of photon penetration depth in visible-light region. Over past decade, NIR has extended to near-infrared II (NIR-II: 1000–1700 region, offering high-resolution and low background by suppressing light scattering, autofluorescence tissues. fluorescent probes from NIR-I NIR-II, with diverse functionalities, are increasingly utilized across fields meet various detection needs explore physiological events real time spatial dimensions. This review discusses recent advancements small-molecule dyes probes, particularly those based on cyanine rhodamine scaffolds, highlighting examples their applications bioimaging.

Language: Английский

Citations

0
Exploiting Flavylium Merocyanine Dyes for Intrinsic, Multiplexed Labeling of the Endoplasmic Reticulum DOI Creative Commons
Quintashia D. Wilson,

Helen H. Lin,

Eric Y. Lin

et al.

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 4, 2025

Merocyanine dyes are a versatile class of donor-acceptor polymethine that exhibit unique properties depending on their structural makeup and surrounding environment. Scaffolds favor the cyanine state (i.e., narrow, red-shifted absorption high fluorescence quantum yields) in biologically relevant settings highly advantageous for multiplexed labeling experiments, but remain limited by visible absorption. Herein, we synthesize new far-red (650-700 nm) to near-infrared (NIR, 700-1000 flavylium merocyanine demonstrate that, unlike conventional scaffolds, they with increasing solvent viscosity hydrogen bond donation, rather than polarity. We leverage these live cell labeling, where observed intrinsic targeting endoplasmic reticulum (ER) lipid droplets, minimal crosstalk commercial stains. reveal ER is achieved dipolarity lipophilicity (ClogP) architecture, making this simple, alternative more structurally complex stains currently available.

Language: Английский

Citations

0