Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: Aug. 1, 2024
Bacterial-derived
micro-/nanomedicine
has
garnered
considerable
attention
in
anticancer
therapy,
owing
to
the
unique
natural
features
of
bacteria,
including
specific
targeting
ability,
immunogenic
benefits,
physicochemical
modifiability,
and
biotechnological
editability.
Besides,
bacterial
components
have
also
been
explored
as
promising
drug
delivery
vehicles.
Harnessing
these
features,
cutting-edge
biotechnologies
applied
attenuated
tumor-targeting
bacteria
with
properties
or
functions
for
potent
effective
cancer
treatment,
strategies
gene-editing
genetic
circuits.
Further,
advent
bacteria-inspired
micro-/nanorobots
mimicking
artificial
systems
furnished
fresh
perspectives
formulating
developing
highly
efficient
systems.
Focusing
on
advantages
this
review
delves
into
advances
bacteria-derived
treatment
recent
years,
which
experienced
a
process
from
living
entities
Meanwhile,
summary
relative
clinical
trials
is
provided
primary
challenges
impeding
their
application
are
discussed.
Furthermore,
future
directions
suggested
combat
cancer.
Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Nov. 14, 2024
Abstract
Tirapazamine
(TPZ),
an
antitumor
prodrug,
can
be
activated
in
hypoxic
environment.
It
specifically
targets
the
microenvironment
of
tumors
and
produces
toxic
free
radicals.
However,
due
to
tumor
is
not
completely
hypoxic,
TPZ
often
fails
effectively
treat
entire
tissue,
resulting
suboptimal
therapeutic
outcomes.
Herein,
a
low
pathogenic
Escherichia
coli
TOP10
utilized
selectively
colonize
tissues,
disrupt
blood
vessels,
induce
thrombus
formation,
leading
expansion
region
improving
effect
TPZ.
Additionally,
thermosensitive
hydrogel
constructed
by
Pluronic
F‐127
(F127),
which
undergoes
gelation
situ
at
site,
sustained
release
To
monitor
process,
it
genetically
modified
integrating
bioluminescent
system
luxCDABE
(TOP10‐Lux).
The
signal
associated
with
hypoxia
enhancement
beneficial
for
monitoring
bioluminescence
imaging.
In
murine
colon
cancer
model,
TOP10‐Lux
combined
TPZ‐loaded
F127
suppressed
growth,
treatment
process
efficiently
monitored.
Together,
this
work
employs
enhance
efficacy
providing
effective
strategy
bacteria‐based
tumor‐targeted
chemotherapy
monitoring.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: April 23, 2025
Integrating
nucleic
acids
(NAs)
with
nanomaterials
has
substantially
advanced
biomedical
research,
enabling
critical
applications
in
biosensing,
drug
delivery,
therapeutics,
and
the
synthesis
of
nanomaterials.
At
core
these
advances
are
reactions
NAs
on
nanomaterial
surfaces,
encompassing
conjugation
(covalent
non-covalent),
detachment
(physical
chemical),
signal
amplification
(enzyme-mediated
amplification,
enzyme-free
DNA
Walker).
Here,
we
review
fundamental
mechanisms
recent
progress
acid
discuss
emerging
for
diagnostics,
nanomedicine,
gene
therapy,
explore
persistent
challenges
field.
We
offer
a
forward-looking
perspective
how
future
developments
could
better
control,
optimize,
harness
transformative
nanomedicine
engineering.
Nano Letters,
Journal Year:
2023,
Volume and Issue:
24(1), P. 130 - 139
Published: Dec. 27, 2023
Photothermal
immunotherapy
has
become
a
promising
strategy
for
tumor
treatment.
However,
the
intrinsic
drawbacks
like
light
instability,
poor
immunoadjuvant
effect,
and
accumulation
of
conventional
inorganic
or
organic
photothermal
agents
limit
their
further
applications.
Based
on
superior
carrying
capacity
active
targeting
property
living
bacteria,
an
immunoadjuvant-intensified
engineered
tumor-targeting
bacterium
was
constructed
to
achieve
effective
immunotherapy.
Specifically,
imiquimod
(R837)-loaded
thermosensitive
liposomes
(R837@TSL)
were
covalently
decorated
onto
Rhodobacter
sphaeroides
(R.S)
obtain
nanoimmunoadjuvant-armed
bacteria
(R.S-R837@TSL).
The
R.S
combined
R837@TSL
in
situ
near-infrared
(NIR)
laser-controlled
release
R837.
Meanwhile,
immunogenic
cell
death
(ICD)
caused
by
effect
R.S-R837@TSL,
synergizes
with
released
immunoadjuvants
promote
maturation
dendritic
cells
(DCs),
which
enhance
cytotoxic
T
lymphocytes
(CTLs)
infiltration
eradication.
photosynthetic
armed
immunoadjuvant-loaded
provide
immunoadjuvant-enhanced
cancer
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(35)
Published: Aug. 1, 2024
Bacterial-derived
micro-/nanomedicine
has
garnered
considerable
attention
in
anticancer
therapy,
owing
to
the
unique
natural
features
of
bacteria,
including
specific
targeting
ability,
immunogenic
benefits,
physicochemical
modifiability,
and
biotechnological
editability.
Besides,
bacterial
components
have
also
been
explored
as
promising
drug
delivery
vehicles.
Harnessing
these
features,
cutting-edge
biotechnologies
applied
attenuated
tumor-targeting
bacteria
with
properties
or
functions
for
potent
effective
cancer
treatment,
strategies
gene-editing
genetic
circuits.
Further,
advent
bacteria-inspired
micro-/nanorobots
mimicking
artificial
systems
furnished
fresh
perspectives
formulating
developing
highly
efficient
systems.
Focusing
on
advantages
this
review
delves
into
advances
bacteria-derived
treatment
recent
years,
which
experienced
a
process
from
living
entities
Meanwhile,
summary
relative
clinical
trials
is
provided
primary
challenges
impeding
their
application
are
discussed.
Furthermore,
future
directions
suggested
combat
cancer.
