MedComm,
Journal Year:
2024,
Volume and Issue:
5(8)
Published: July 20, 2024
Abstract
Nanomaterials
have
aroused
great
interests
in
drug
delivery
due
to
their
nanoscale
structure,
facile
modifiability,
and
multifunctional
physicochemical
properties.
Currently,
stimuli‐responsive
nanomaterials
that
can
respond
endogenous
or
exogenous
stimulus
display
strong
potentials
biomedical
applications.
In
comparison
with
conventional
nanomaterials,
improve
therapeutic
efficiency
reduce
the
toxicity
of
drugs
toward
normal
tissues
through
specific
targeting
on‐demand
release
at
pathological
sites.
this
review,
we
summarize
responsive
mechanism
a
variety
stimulus,
including
pH,
redox,
enzymes
within
microenvironment,
as
well
such
thermal
effect,
magnetic
field,
light,
ultrasound.
After
that,
applications
(e.g.,
delivery,
imaging,
theranostics)
diverse
array
common
diseases,
cardiovascular
cancer,
neurological
disorders,
inflammation,
bacterial
infection,
are
presented
discussed.
Finally,
remaining
challenges
outlooks
future
research
directions
for
also
We
hope
review
provide
valuable
guidance
developing
accelerate
diseases
diagnosis
treatment.
Exploration,
Journal Year:
2024,
Volume and Issue:
4(6)
Published: March 24, 2024
Abstract
Photothermal
therapy
(PTT)
has
garnered
significant
attention
in
recent
years,
but
the
standalone
application
of
PTT
still
faces
limitations
that
hinder
its
ability
to
achieve
optimal
therapeutic
outcomes.
Nitric
oxide
(NO),
being
one
most
extensively
studied
gaseous
molecules,
presents
itself
as
a
promising
complementary
candidate
for
PTT.
In
response,
various
nanosystems
have
been
developed
enable
simultaneous
utilization
and
NO‐mediated
gas
(GT),
with
integration
photothermal
agents
(PTAs)
thermally‐sensitive
NO
donors
prevailing
approach.
This
combination
seeks
leverage
synergistic
effects
GT
while
mitigating
potential
risks
associated
toxicity
through
use
single
laser
irradiation.
Furthermore,
additional
internal
or
external
stimuli
employed
trigger
release
when
combined
different
types
PTAs,
thereby
further
enhancing
efficacy.
comprehensive
review
aims
summarize
advancements
gas‐assisted
cancer
treatment.
It
commences
by
providing
an
overview
precursors,
including
those
sensitive
photothermal,
light,
ultrasound,
reactive
oxygen
species,
glutathione.
These
precursors
are
discussed
context
dual‐modal
PTT/GT.
Subsequently,
incorporation
other
treatment
modalities
such
chemotherapy
(CHT),
photodynamic
(PDT),
alkyl
radical
therapy,
radiation
immunotherapy
(IT)
creation
triple‐modal
nanoplatforms
is
presented.
The
explores
tetra‐modal
therapies,
PTT/GT/CHT/PDT,
PTT/GT/CHT/chemodynamic
(CDT),
PTT/GT/PDT/IT,
PTT/GT/starvation
(ST)/IT,
PTT/GT/Ca
2+
overload/IT,
PTT/GT/ferroptosis
(FT)/IT,
PTT/GT/CDT/IT.
Finally,
challenges
future
perspectives
concerning
these
novel
paradigms
discussed.
anticipated
serve
valuable
resource
studies
focused
on
development
innovative
photothermal/NO‐based
nanotheranostics.
Nanotechnology Reviews,
Journal Year:
2024,
Volume and Issue:
13(1)
Published: Jan. 1, 2024
Abstract
Cancer
treatment
often
causes
adverse
effects
and
toxicity,
as
chemotherapy
drugs
affect
both
cancerous
healthy
cells.
Scientists
seek
to
target
tumor
cells
specifically
minimize
harm
normal
Smart
nanoparticles
(NPs)
are
a
modern
technique
that
can
release
when
triggered
by
internal
or
external
stimuli,
such
temperature,
pH,
ultrasound,
etc
.
This
review
covers
stimuli-responsive
micelle-based
(SRM-NPs),
promising
drug
delivery
platform
enhance
efficacy
reduce
toxicity.
It
discusses
the
recent
developments
applications
of
SRM-NPs,
their
responsiveness
different
potential
overcome
resistance
adaptive
responses.
also
addresses
challenges
issues
related
stability,
reproducibility,
biocompatibility,
safety,
optimization.
The
study
concludes
SRM-NPs
have
great
for
delivery,
but
more
research
development
needed
improve
clinical
utility.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(19)
Published: Feb. 1, 2024
Abstract
Drug
resistance
significantly
hampers
the
clinical
application
of
existing
platinum‐based
anticancer
drugs.
New
platinum
medications
that
possess
distinct
mechanisms
action
are
highly
desired
for
treatment
Pt‐resistant
cancers.
Herein,
a
nanoscale
trans
‐platinum(II)‐based
supramolecular
coordination
self‐assembly
(Pt–TCPP–BA)
is
prepared
via
using
‐[PtCl
2
(pyridine)(NH
3
)]
(transpyroplatin),
tetracarboxylporphyrin
(TCPP),
and
benzoic
acid
(BA)
as
building
blocks
to
combat
drug
in
chemotherapy.
Mechanistic
studies
indicate
Pt–TCPP–BA
shows
hydrogen‐peroxide‐responsive
dissociation
behavior
along
with
generation
bioactive
‐Pt(II)
TCPP–Pt
species.
Different
from
cisplatin,
these
degradation
products
interact
DNA
interstrand
cross‐links
small
groove
binding,
induce
significant
upregulation
cell‐death‐related
proteins
such
p53,
cleaved
caspase
3,
p21,
phosphorylated
H2A
histone
family
member
X
cisplatin‐resistant
cancer
cells.
As
result,
exhibits
potent
killing
effects
against
tumors
both
vitro
vivo.
Overall,
this
work
not
only
provides
new
combating
drug‐resistant
but
also
offers
paradigm
development
BIO Integration,
Journal Year:
2024,
Volume and Issue:
5(1)
Published: Jan. 1, 2024
Abstract
Cancer
is
a
significant
disease
that
poses
major
threat
to
human
health.
Image-guided
cancer
therapy
refers
series
of
medical
procedures
use
imaging
technology
precisely
locate
and
treat
cancer.
Combining
the
dual
characteristics
images
functional
nanomaterial
(NM)
drug
carriers,
various
integrated
diagnosis
treatment
probes
have
been
developed
for
in
vivo
dynamic
monitoring
therapeutic
effect
evaluation
drugs
based
on
imaging.
Copper
(Cu)-based
NMs
emerged
as
valuable
products
nanotechnology
due
their
unique
physicochemical
properties,
which
are
influenced
by
factors,
such
size,
shape,
surface
properties.
In
field
imaging,
Cu-based
offer
combination
desirable
characteristics,
including
fluorescence
emission,
contrast
enhancement,
radiolabeling
stability.
These
properties
form
foundation
wide
range
modalities.
addition,
can
be
used
carrier
diagnostic
or
synergistic
multiple
modalities
realized
doping
transition
metals
into
heterostructures.
become
an
important
basis
imaging-guided
with
NMs.
this
review
we
introduce
biocompatible
image-guided
provide
overview
promising
outcomes
biomedical
research.
Small,
Journal Year:
2023,
Volume and Issue:
19(52)
Published: Aug. 30, 2023
Abstract
Antibacterial
theranostic
nanoplatforms,
which
integrate
diagnostic
and
therapeutic
properties,
exhibit
gigantic
application
prospects
in
precision
medicine.
However,
traditional
nanoplatforms
usually
present
an
always‐on
signal
output,
leads
to
poor
specificity
or
selectivity
the
treatment
of
bacterial
infections.
To
address
this
challenge,
stimuli‐actuated
turn‐on
are
developed
for
simultaneous
activation
signals
(e.g.,
fluorescent,
photoacoustic,
magnetic
signals)
initiation
antibacterial
treatment.
Specifically,
by
combining
infection
microenvironment‐responsive
visual
activity,
these
exert
both
higher
accurate
diagnosis
rates
more
effective
effects.
In
review,
imaging
strategies
that
commonly
used
clinic
first
briefly
introduced.
Next,
recent
progress
treating
infectious
diseases
is
summarized
detail.
Finally,
current
bottlenecks
future
opportunities
also
outlined
discussed.
