Vesicular Drug Delivery Systems: Promising Approaches in Ocular Drug Delivery

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 511 - 511

Published: April 16, 2024

Ocular drug delivery poses unique challenges due to the complex anatomical and physiological barriers of eye. Conventional dosage forms often fail achieve optimal therapeutic outcomes poor bioavailability, short retention time, off-target effects. In recent years, vesicular systems have emerged as promising solutions address these challenges. Vesicular systems, such liposome, niosome, ethosome, transfersome, others (bilosome, transethosome, cubosome, proniosome, chitosome, terpesome, phytosome, discome, spanlastics), offer several advantages for ocular delivery. These include improved prolonged time on surface, reduced systemic side effects, protection drugs from enzymatic degradation dilution by tears. Moreover, formulations can be engineered targeted specific tissues or cells, enhancing efficacy while minimizing They also enable encapsulation a wide range molecules, including hydrophilic, hydrophobic, macromolecular drugs, possibility combination therapy facilitating co-delivery multiple drugs. This review examines their over conventional production techniques, applications in management diseases.

Language: Английский

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Insights into ocular therapeutics: A comprehensive review of anatomy, barriers, diseases and nanoscale formulations for targeted drug delivery

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105785 - 105785

Published: May 15, 2024

Language: Английский

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Metal-phenolic nanoparticles enhance low temperature photothermal therapy for bacterial biofilm in superficial infections

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Nov. 15, 2024

Bacterial infections, especially induced by multidrug-resistant pathogens, have become a significant global health concern. In the infected tissues, biofilms not only serve as source of nutrients but also act protective barriers that impede antibiotic penetration. Herein, we developed tea polyphenols epigallocatechin gallate (EGCG) Au nanoparticles (E-Au NPs) through direct one-step self-assembly methods EGCG chelating with ions to eradicate antibiotic-resistant bacteria methicillin-resistant Staphylococcus aureus (MRSA) and prevent formation biofilm under near-infrared (NIR) irradiation. The outstanding antibacterial effect involved in mild photothermal therapy, reactive oxygen species production, pathogenicity-related genes regulation, quinoprotein were specific polyphenol-based NPs. excellent anti-inflammatory therapeutic efficacy E-Au NPs was validated topically applied murine MRSA-infected skin wounds keratitis model vivo kill bacteria, reduce inflammation response promote wound healing. Furthermore, ophthalmic systemic biosafety profiles thoroughly evaluated while no side effects revealed achieving balance between high-efficiency properties biocompatibility. This study provides an effective agent metal-phenolic materials for superficial tissue infection favorable prognosis potential clinical translation.

Language: Английский

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Co-delivery of antioxidants and siRNA-VEGF: promising treatment for age-related macular degeneration

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 3, 2025

Language: Английский

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Nanoemulsion-based pseudopolyrotaxane hydrogel for enhanced corneal bioavailability and treatment of corneal inflammation

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 379, P. 14 - 29

Published: Jan. 16, 2025

Language: Английский

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