An injectable, self-healable, and antimicrobial hydroxypropyl chitosan/poly(vinyl alcohol) hydrogel for drug delivery systems

Colloids and Surfaces A Physicochemical and Engineering Aspects, Journal Year: 2024, Volume and Issue: 698, P. 134587 - 134587

Published: Oct. 1, 2024

Language: Английский

---

Advancing drug delivery research: sustainable strategies for innovation and translation

Drug Delivery and Translational Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 10, 2025

Language: Английский

---

Tribological and microstructural characterization of laser microtextured Ti-6Al-4V ELI alloy evaluated against UHMWPE and PEEK for biomedical applications

Wear, Journal Year: 2025, Volume and Issue: unknown, P. 205931 - 205931

Published: Feb. 1, 2025

Language: Английский

---

TENG-based self-powered device- the heart of life

Nano Energy, Journal Year: 2023, Volume and Issue: 119, P. 109080 - 109080

Published: Nov. 11, 2023

Language: Английский

---

3D Printing Direct Powder Extrusion in the Production of Drug Delivery Systems: State of the Art and Future Perspectives

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(4), P. 437 - 437

Published: March 22, 2024

The production of tailored, on-demand drug delivery systems has gained attention in pharmaceutical development over the last few years, thanks to application 3D printing technology field. Recently, direct powder extrusion (DPE) emerged among extrusion-based additive manufacturing techniques. It is a one-step procedure that allows processing powdered formulations. aim this systematic literature review analyze using DPE. A total 27 articles have been identified through scientific databases (Scopus, PubMed, and ScienceDirect). main characteristics three types printers based on DPE discussed. selection polymers auxiliary excipients, as well flowability mixture, rheological properties molten material, temperatures critical parameters for successful printing. wide range with varied geometries different release profiles intended oral, buccal, parenteral, transdermal routes produced. ability technique manufacture personalized, proven. For all these reasons, its implementation hospital settings near future seems promising.

Language: Английский

---

Reservoir-type intranasal implants for sustained release of risperidone: A potential alternative for long-term treatment of schizophrenia

Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 99, P. 105973 - 105973

Published: July 16, 2024

To overcome the challenges of blood-brain barrier for drug delivery to central nervous system (CNS), intranasal implants were developed improve management CNS conditions, such as schizophrenia. In present work, we and characterised a drug-containing implant consisting two parts: core layer made from risperidone (RIS) water-soluble polymers, including poly(vinylpyrrolidone) (PVP) poly(ethylene glycol) (PEG), coating poly(caprolactone) (PCL) membrane. The obtained implants, where contained 75 % w/w risperidone, using several techniques: scanning electron microscopy (SEM), thermogravimetric analysis (TGA), differential calorimetry (DSC), attenuated total reflectance-Fourier transform infrared (ATR-FTIR). Moreover, in vitro release profile RIS was studied, showing that PCL membrane could extend 2 days up 100 days. PCL-coated exhibited linear over first 10 days, followed by slower rate reached another phase 40 Subsequently, rates progressively slowed down. Finally, results biocompatibility studies indicated biocompatible non-cytotoxic. These findings suggest prepared this work have potential provide long-acting targeting brain.

Language: Английский

---

Separable nanocomposite hydrogel microneedles for intradermal and sustained delivery of antigens to enhance adaptive immune responses

Acta Biomaterialia, Journal Year: 2024, Volume and Issue: 185, P. 203 - 214

Published: July 23, 2024

Language: Английский

---

Drug Nanocrystals: Surface Engineering and Its Applications in Targeted Delivery

iScience, Journal Year: 2024, Volume and Issue: 27(11), P. 111185 - 111185

Published: Oct. 17, 2024

Language: Английский

---

MAP-box: a novel, low-cost and easy-to-fabricate 3D-printed box for the storage and transportation of dissolving microneedle array patches

Drug Delivery and Translational Research, Journal Year: 2023, Volume and Issue: 14(1), P. 208 - 222

Published: July 21, 2023

Research on the use of microarray patches (MAPs) has progressed at an unprecedented rate over years, leading to development many novel drug delivery systems. As technology approaches patients, there are several key aspects that ought be addressed in order facilitate smooth translation MAPs from bench bedside. One integral factor includes choice devices and packaging for storage MAPs. In current work, a slide-and-seal box, MAP-box, was developed dissolving MAPs, using fused-deposition modelling. The device been designed act as pill-box not only provide protection environment, but also improve patient's adherence treatment. overall design MAP-box simple, yet offers capability sealing protecting up 30 days. Donepezil HCl formulated into dissolvable MAP, which used treat dementia related Alzheimer's disease. This compound model formulation evaluate utility 3D printed when placed under three conditions: 5 °C ambient humidity, 25 65% relative humidity 40 75% humidity. It shown box able confer days accelerated stability study conditions loading, mechanical properties insertion remained unaffected compared unpackaged stored these same parameters. These preliminary data evidence prototype may great single or multiple Nevertheless, future work will needed their patient usability its application different types MAP systems fully validate robustness prototype.

Language: Английский

---

In-vivo studies of targeted and localized cancer drug release from microporous poly-di-methyl-siloxane (PDMS) devices for the treatment of triple negative breast cancer

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Jan. 2, 2024

Abstract Triple-negative breast cancer (TNBC) treatment is challenging and frequently characterized by an aggressive phenotype low prognosis in comparison to other subtypes. This paper presents fabricated implantable drug-loaded microporous poly-di-methyl-siloxane (PDMS) devices for the delivery of targeted therapeutic agents [Luteinizing Hormone-Releasing Hormone conjugated paclitaxel (PTX-LHRH) Luteinizing prodigiosin (PG-LHRH)] possible prevention triple-negative recurrence. In vitro assessment using Alamar blue assay demonstrated a significant reduction (p < 0.05) percentage cell growth time-dependent manner groups treated with PG, PG-LHRH, PTX, PTX-LHRH. Subcutaneous xenograft tumors were then induced athymic female nude mice that four weeks old. Two later, surgically but partially removed, device implanted. Mice observed tumor regrowth organ toxicity. The animal study revealed there was no regrowth, six post-treatment, when LHRH drugs (LHRH-PTX LHRH-PGS) used treatment. cytotoxic effects released on liver, kidney, lung are assessed quantitative biochemical from blood samples groups. Ex vivo histopathological results tissues showed did not induce any adverse effect kidneys, or lungs, based qualitative toxicity studies. implications discussed localized triple negative cancer.

Language: Английский

---