Revista Cereus,
Journal Year:
2023,
Volume and Issue:
15(4)
Published: Jan. 1, 2023
A
pesquisa
explorou
a
relação
entre
disbiose
intestinal
e
atividade
física,
investigando
associações
com
doenças
neurológicas.
Os
documentos
foram
extraídos
das
bases
de
dados
ferramentas
Scielo,
Pubmed
Web
of
Science
Search
acordo
as
palavras-chave
definidas
pelo
DeCS/MeSH.
Utilizou
revisões
sistemáticas,
meta-análise
para
garantir
qualidade
metodológica.
Para
análise
qualitativa
foi
seguido
normas
diretrizes
denominado
RATS
(Relevância,
Adequação,
Transparência
Solidez)
contextual
realizada
através
do
software
Rayyan
-
AI
Powered
Tool
for
Systematic
Literature
Reviews
cegas
pelos
autores.
Na
contextualização
os
pesquisadores
elucidou
alterações
na
composição
função
da
microbiota
podem
estar
envolvidas
no
desenvolvimento
progressão
sistema
nervoso
central;
resultados
indicam
significativas
inflamatórias
intestinais
é
um
risco
neurodegenerativas
o
método
genômica
demonstrou
ser
mais
significativo
fornecem
suporte
à
hipótese
que
processos
inflamatórios
crônicos
desempenham
condições
doença
Alzheimer
distúrbios
trato
gastrointestinal.
Concluiu-se
afeta
saúde
humana,
física
dieta
equilibrada
prevenir
neurológicas,
incluindo
Alzheimer.
Entretanto,
pesquisas
são
necessárias
entender
completamente
essa
interação
complexa
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 23, 2024
The
gut-brain
axis,
a
bidirectional
communication
network
between
the
gastrointestinal
tract
and
central
nervous
system,
regulates
various
physiological
processes
crucial
for
health,
including
immune
response,
metabolism,
neurotransmitter
production.
In
context
of
neurodegenerative
diseases,
especially
Alzheimer's
disease
(AD),
understanding
intricate
connection
axis
has
gained
significance.
Disturbances
along
this
have
been
implicated
in
emphasizing
its
role
AD
pathogenesis.
Microbiota
dysbiosis,
influenced
by
diet,
lifestyle,
genetics,
contributes
to
altered
gut
permeability,
leading
protein
dyshomeostasis,
astroglial
activation,
neuroinflammation,
cognitive
decline.
Understanding
these
mechanisms
is
developing
interventions
restore
healthy
microbiota
potentially
mitigate
AD-related
involves
microbial
metabolites,
influencing
oxidative
stress,
aggregation,
other
pathways
linked
neuroprotection.
Modulating
through
dietary
changes,
prebiotics,
probiotics,
or
fecal
transplantation
emerges
as
promising
approach
target
decline
AD.
Despite
progress,
challenges
persist,
correlational
nature
studies,
complexity
microbiome,
variations
methodologies.
Standardization
essential
reliable
findings
identification
biomarkers
associated
with
Unanswered
questions
warrant
further
exploration,
particularly
specific
mechanisms,
temporal
dynamics
influence
diet
lifestyle
on
Future
perspectives
involve
therapeutic
targeting
personalized
medicine
optimize
outcomes
based
individual
characteristics.
Parkinson's
disease
(PD),
the
second
most
common
neurological
ailment
in
world
after
Alzheimer's
(AD),
affects
about
1%
of
those
over
65
years.
Exosomes
were
first
thought
to
be
useless
cell
debris.
It
has
been
discovered
that
exosomes
contain
a
variety
non-coding
RNAs,
including
microRNAs,
lncRNAs,
and
circRNAs,
as
well
other
bioactive
compounds.
A
few
these
compounds
are
functional
messenger
RNAs
(mRNAs),
certain
proteins,
lipids,
chemicals.
Our
understanding
exosome
function
body
improved
result
this
information.
physiological
activities
show
important
include
migration,
angiogenesis,
intercellular
communication,
anti-tumor
immunity.
can
help
nervous
system's
cells
communicate
with
one
another,
get
rid
waste,
keep
myelin
coating
place.
Similar
this,
it
is
possible
development
central
system
illnesses
like
influenced
by
brain
exosomes.
The
several
neurodegenerative
disorders
(NDD),
mostly
attributed
extracellular
vehicles
(EVs)
known
(EXOs).
As
result,
have
attracted
attention
EVs
pathophysiological
roles.
Because
their
shown
ability
transport
both
pathogenic
therapeutic
cargo,
researchers
altered
EXOs
for
use
drug
delivery.
European Journal of Neuroscience,
Journal Year:
2024,
Volume and Issue:
60(8), P. 6057 - 6090
Published: Sept. 19, 2024
Neurodegenerative
diseases
are
characterized
by
progressive
deterioration
of
the
nervous
system.
Alzheimer's
disease
(AD),
Parkinson's
(PD),
amyotrophic
lateral
sclerosis
(ALS),
and
Huntington's
(HD)
prominently
life-threatening
examples
neurodegenerative
diseases.
The
complexity
pathophysiology
in
causes
difficulties
diagnosing.
Although
drugs
temporarily
help
to
correct
specific
symptoms
including
memory
loss
degeneration,
a
complete
treatment
has
not
been
found
yet.
New
therapeutic
approaches
have
developed
understand
treat
underlying
pathogenesis
With
this
purpose,
clustered-regularly
interspaced
short
palindromic
repeats/CRISPR-associated
protein
(CRISPR/Cas)
technology
recently
suggested
new
option.
Editing
genome
is
carried
out
insertion
deletion
processes
on
DNA.
Safe
delivery
CRISPR/Cas
system
targeted
cells
without
affecting
surrounding
frequently
investigated.
Extracellular
vesicles
(EVs),
that
exosomes,
used
studies.
In
review,
EV
for
diagnosis
and/or
AD,
PD,
ALS,
HD
reviewed.
technologies,
which
stand
as
approaches,
may
offer
definitive
option
Nutrients,
Journal Year:
2024,
Volume and Issue:
16(20), P. 3567 - 3567
Published: Oct. 21, 2024
This
systematic
literature
review
aims
to
answer
the
question
of
how
micronutrients
might
influence
development
and
progression
dementia.
In
present
work,
we
focused
on
an
overview
updated
relevant
published
in
last
two
decades.
delineate
relationship
between
micronutrient
supplementation
cognitive
decline
older
subjects.
carrying
out
this
review,
followed
PRISMA,
our
search
was
performed
PubMed.
includes
only
primary
studies
that
have
investigated
efficacy
nutritional
interventions
for
prevention
dementia
improvement
function
subjects
aged
65
years
or
with
normal
cognition,
mild
impairment
(MCI),
Alzheimer's
disease
(AD).
A
gross
heterogeneity
forbids
possibility
a
direct
comparison
results.
inclusion
criteria
restrictions
has
been
conducted
check
validity
reliability
thirty-three
were
included.
Results
shown
vitamin
D,
probiotics,
PUFAs
would
most
likely
reduce
decline,
dementia,
AD
compared
vitamins
A,
B,
C,
E,
which
seen
be
relatively
ineffective.
Of
note,
when
considering
B
supplementation,
positive
effects
observed
non-aspirin
users
having
high
ω-3
fatty
acid
(ω-3
FA)
plasma
levels.
some
cases,
however,
there
genotypic
differences
response
supplementation.
Biology,
Journal Year:
2023,
Volume and Issue:
13(1), P. 8 - 8
Published: Dec. 22, 2023
This
review
summarizes
the
protective
effects
of
probiotics
against
Alzheimer’s
disease
(AD),
one
most
common
neurodegenerative
disorders
affecting
older
adults.
is
characterized
by
deposition
tau
and
amyloid
β
peptide
(Aβ)
in
different
parts
brain.
Symptoms
observed
patients
with
AD
include
struggles
writing,
speech,
memory,
knowledge.
The
gut
microbiota
reportedly
plays
an
important
role
brain
functioning
due
to
its
bidirectional
communication
via
gut–brain
axis.
emotional
cognitive
centers
are
linked
functions
peripheral
intestinal
system
this
Dysbiosis
has
been
disorders,
indicating
significance
homeostasis
for
proper
function.
Probiotics
play
protecting
symptoms
as
they
restore
a
great
extent.
characteristics,
status
axis,
AD.
Review
research
articles
related
treatment
were
searched
PubMed
database.
Recent
studies
conducted
using
animal
models
given
preference.
clinical
trials
separately.
Several
on
human
clearly
explain
benefits
improving
cognition
memory
experimental
subjects.
Based
these
studies,
novel
therapeutic
approaches
can
be
designed
The Egyptian Journal of Neurology Psychiatry and Neurosurgery,
Journal Year:
2024,
Volume and Issue:
60(1)
Published: May 27, 2024
Abstract
Background
Alzheimer’s
disease
(AD)
stands
as
a
formidable
challenge
within
the
realm
of
neurodegenerative
disorders,
characterized
by
its
inexorable
progression
and
profound
cognitive
impairments
it
engenders.
Despite
decades
research,
management
AD
remains
in
conundrum,
with
currently
available
treatments
offering
only
modest
symptomatic
relief
none
that
can
definitively
alter
course
disease.
Objective
This
investigation
seeks
to
provide
concise
overview
influence
probiotics
on
aspects
AD,
drawing
upon
compilation
conducted
studies.
Methods
The
study
was
means
comprehensive
searches
MEDLINE,
Pubmed,
Google
Scholar
databases
spanning
from
January
2015
December
2020.
composition
this
review
adhered
guidelines
outlined
Preferred
Reporting
Items
for
Systematic
Reviews
Meta-Analyses
(PRISMA)
statement.
evaluation
eligibility
criteria
guided
Population,
Intervention,
Comparator,
Outcome,
Study
Design
(PICOS)
framework,
methodology
systematically
applied
each
identified
research
entry.
Results
Upon
implementation
search
protocol,
total
five
articles
satisfied
predetermined
inclusion
were
incorporated
into
review.
Among
these,
four
encompassed
randomized
controlled
trials
(RCTs),
while
fifth
pertained
an
explorative
interventional
study.
progressive
affliction
considerable
clinical
import.
Through
assessment
diverse
investigations,
compelling
evidence
has
emerged
affirming
probiotic
microorganisms,
acting
via
intricate
gut–brain
axis
signaling
pathway,
harbor
capacity
ameliorate
function
AD.
collective
findings
across
all
studies
unequivocally
indicate
notable
enhancement
subsequent
administration
supplementation
(
p
<
0.05).
While
not
domains
exhibit
amelioration
response
supplementation,
consideration
incorporating
therapeutic
schema
warrants
deliberation
strategy
enhance
performance.
Conclusion
pathophysiology
exerts
discernible
well-being.
Notably,
symbiotic
interplay
between
gut
brain,
elucidated
through
axis,
emerges
conduit
which
could
potentially
modulate
function.
