Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 233 - 248
Published: Oct. 25, 2024
Language: Английский
Probiotics and Antimicrobial Proteins, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 14, 2025
Language: Английский
Citations
8
ACS Omega, Journal Year: 2025, Volume and Issue: 10(6), P. 5148 - 5171
Published: Feb. 3, 2025
Alzheimer's disease (AD) is an aging-related irreversible neurodegenerative affecting mostly the elderly population. The main pathological features of AD are extracellular Aβ plaques generated by APP cleavage through amyloidogenic pathway, intracellular neurofibrillary tangles (NFT) resulting from hyperphosphorylated tau proteins, and cholinergic neurodegeneration. However, actual causes unknown, but several studies suggest hereditary mutations in PSEN1 -2, APOE4, APP, TAU genes major perpetrators. In order to understand etiology pathogenesis AD, various hypotheses proposed. These include following hypotheses: amyloid accumulation, tauopathy, inflammation, oxidative stress, mitochondrial dysfunction, glutamate/excitotoxicity, deficiency, gut dysbiosis. Currently approved therapeutic interventions donepezil, galantamine, rivastigmine, which cholinesterase inhibitors (ChEIs), memantine, N-methyl-d-aspartate (NMDA) antagonist. treatment strategies focus on only symptomatic management attenuating symptoms not regeneration neurons or clearance Tau. This review focuses pathophysiology, novel targets, disease-altering treatments such as α-secretase modulators, active immunotherapy, passive natural antioxidant products, nanomaterials, antiamyloid therapy, aggregation inhibitors, transplantation fecal microbiota stem cells, microtubule stabilizers that clinical trials still under investigation.
Language: Английский
Citations
1
Foods, Journal Year: 2025, Volume and Issue: 14(9), P. 1531 - 1531
Published: April 27, 2025
Alzheimer’s disease (AD) has emerged as a global public health priority characterized by escalating prevalence and the limited efficacy of current therapeutic approaches. Although pathological complexity AD is well-recognized, its underlying etiology remains incompletely elucidated. Current research highlights bidirectional gut–brain axis (GBA) interaction, wherein gut microbiome perturbations may impair intestinal barrier stability, influence immune responses, blood–brain permeability through microbial metabolite-mediated pathways, thereby contributing to pathophysiology. Notably, probiotics demonstrate potential restoring homeostasis, reinforcing integrity, mitigating neuroinflammatory responses via GBA. This review focuses on investigating alterations in pathogenesis, interaction with GBA, significance pathogenesis. By synthesizing clinical evidence, this aims establish scientific foundation for probiotic-based interventions novel strategy management.
Language: Английский
Citations
0
Neurochemical Research, Journal Year: 2024, Volume and Issue: 50(1)
Published: Nov. 14, 2024
Language: Английский
Citations
3
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(9), P. 4696 - 4696
Published: April 25, 2024
Prominent pathological features of Huntington’s disease (HD) are aggregations mutated Huntingtin protein (mHtt) in the brain and neurodegeneration, which causes characteristic motor (such as chorea dystonia) non-motor symptoms. However, numerous systemic peripheral deficits HD have gained increasing attention recently, since those factors likely modulate progression, including pathology. While whole-body metabolic abnormalities organ-specific pathologies been relatively well described, potential mediators compromised inter-organ communication insufficiently characterized. Therefore, we applied an exploratory literature search to identify such mediators. Unsurprisingly, dysregulation inflammatory factors, circulating mHtt, many other messenger molecules (hormones, lipids, RNAs) were found that suggest impaired communication, gut–brain muscle–brain axis. Based on these findings, aimed assess risks potentials lifestyle interventions thought improve across axes: dietary strategies exercise. We conclude appropriate great reduce symptoms potentially modify progression (possibly via improving signaling) HD. metabolism warrant particular care design exercise programs for people with
Language: Английский
Citations
2
Frontiers in Medicine, Journal Year: 2024, Volume and Issue: 11
Published: Nov. 6, 2024
Antibiotics are safe, effective drugs and continue to save millions of lives prevent long-term illness worldwide. A large body epidemiological, interventional experimental evidence shows that exposure antibiotics has negative effects on human health. We reviewed the literature data links between antibiotic exposure, gut dysbiosis, chronic disease (notably with regard “developmental origins health disease” (“DOHaD”) approach). Molecular biology studies show systemic administration infants a rapid onset but also often long-lasting impact microbial composition gut. Along other environmental factors (e.g., an unhealthy “Western” diet sedentary behavior), induce which can be defined as disruption previously stable, functionally complete microbiota. Gut dysbiosis many harmful Associations early-life have been reported for diseases, including inflammatory bowel disease, celiac some cancers, metabolic diseases (obesity type 2 diabetes), allergic autoimmune disorders, atherosclerosis, arthritis, neurodevelopmental, neurodegenerative neurological diseases. In mechanistic terms, influences through direct mucosal immune pathways, plus wide array or indirect short-chain fatty acids, enteric nervous system, peristaltic motility, production hormones neurotransmitters, loss intestinal barrier integrity leakage pro-inflammatory endotoxin lipopolysaccharide into circulation). To mitigate probiotics in patients is (but not always) associated positive clinical markers scores) biomarkers inflammation activation. Meta-analyses complicated by differences probiotic composition, dose level, treatment duration, large, randomized, controlled trials lacking areas. view critical importance deciding whether prescribe (especially children), we suggest DOHaD concept logically extended “gastrointestinal (“GOHaD”) even “microbiotic (“MOHaD”).
Language: Английский
Citations
2
3 Biotech, Journal Year: 2024, Volume and Issue: 14(12)
Published: Nov. 26, 2024
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 233 - 248
Published: Oct. 25, 2024
Language: Английский
Citations
0