Bipolar disorders

The Lancet, Journal Year: 2020, Volume and Issue: 396(10265), P. 1841 - 1856

Published: Dec. 1, 2020

Language: Английский

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Mechanisms governing activity-dependent synaptic pruning in the developing mammalian CNS

Nature reviews. Neuroscience, Journal Year: 2021, Volume and Issue: 22(11), P. 657 - 673

Published: Sept. 20, 2021

Language: Английский

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Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

eLife, Journal Year: 2020, Volume and Issue: 9

Published: July 14, 2020

The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for vertical transmission SARS-CoV-2 exists. novel canonically utilizes angiotensin-converting enzyme (ACE2) receptor and serine protease TMPRSS2 cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, new single-cell/nuclei RNA-sequencing data, we investigated expression ACE2 throughout pregnancy in placenta as well third-trimester chorioamniotic membranes. We report that co-transcription is negligible placenta, thus not a likely path SARS-CoV-2. By contrast, receptors Zika virus cytomegalovirus, which cause congenital infections, are highly expressed placental types. These data show minimally expresses canonical cell-entry mediators

Language: Английский

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Disease severity, pregnancy outcomes, and maternal deaths among pregnant patients with severe acute respiratory syndrome coronavirus 2 infection in Washington State

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 225(1), P. 77.e1 - 77.e14

Published: Jan. 27, 2021

Language: Английский

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Prenatal and perinatal risk and protective factors for psychosis: a systematic review and meta-analysis

The Lancet Psychiatry, Journal Year: 2020, Volume and Issue: 7(5), P. 399 - 410

Published: March 24, 2020

Language: Английский

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Clinical characteristics of 46 pregnant women with a severe acute respiratory syndrome coronavirus 2 infection in Washington State

American Journal of Obstetrics and Gynecology, Journal Year: 2020, Volume and Issue: 223(6), P. 911.e1 - 911.e14

Published: May 19, 2020

The impact of coronavirus disease 2019 on pregnant women is incompletely understood, but early data from case series suggest a variable course illness asymptomatic or mild to maternal death. It unclear whether manifest enhanced similar influenza viral infection specific risk factors might predispose severe disease.To describe and obstetrical outcomes associated with in pregnancy rapidly inform clinical care.This retrospective study patients laboratory-confirmed acute respiratory syndrome 2 6 hospital systems Washington State between Jan. 21, 2020, April 17, 2020. Demographics, medical history, encounter were abstracted records.A total 46 identified capturing 40% births State. Nearly all individuals symptomatic (93.5%, n=43) the majority their second third trimester (43.5% [n=20] 50.0% [n=23], respectively). Symptoms resolved median 24 days (interquartile range, 13-37). Notably, 7 hospitalized (16%) including 1 admitted intensive care unit. A cases (15%) categorized as nearly being either overweight obese before asthma other comorbidities. Of 8 deliveries that occurred during period, there was preterm birth at 33 weeks' gestation improve pulmonary status woman class III obesity, stillbirth unknown etiology.Severe developed approximately 15% primarily underlying conditions. Obesity may synergistically increase for medically indicated late pregnancy. These findings support categorizing higher-risk group, particularly those chronic

Language: Английский

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Neurodevelopmental Outcomes at 1 Year in Infants of Mothers Who Tested Positive for SARS-CoV-2 During Pregnancy

JAMA Network Open, Journal Year: 2022, Volume and Issue: 5(6), P. e2215787 - e2215787

Published: June 9, 2022

Importance

Epidemiologic studies suggest maternal immune activation during pregnancy may be associated with neurodevelopmental effects in offspring.

Objective

To evaluate whether utero exposure to SARS-CoV-2 is risk for disorders the first 12 months after birth.

Design, Setting, and Participants

This retrospective cohort study examined live offspring of all mothers who delivered between March September 2020 at any 6 Massachusetts hospitals across 2 health systems. Statistical analysis was performed from October December 2021.

Exposures

Maternal infection confirmed by a polymerase chain reaction test pregnancy.

Main Outcomes Measures

Neurodevelopmental determined fromInternational Classification Diseases Related Health Problems, Tenth Revision (ICD-10)diagnostic codes over life; sociodemographic clinical features offspring; drawn electronic record.

Results

The included 7772 births (7466 pregnancies, 96% singleton, 222 positive mothers), mean (SD) age 32.9 (5.0) years; were 9.9% Asian (772), 8.4% Black (656), 69.0% White (5363); 15.1% (1134) Hispanic ethnicity. Preterm delivery more likely among exposed mothers: 14.4% (32) vs 8.7% (654) (P = .003). positivity greater rate diagnoses unadjusted models (odds ratio [OR], 2.17 [95% CI, 1.24-3.79];P .006) as well those adjusted race, ethnicity, insurance status, sex, age, preterm status (adjusted OR, 1.86 1.03-3.36];P .04). Third-trimester larger magnitude 2.34 1.23-4.44];P .01).

Conclusions Relevance

found preliminary evidence that sequelae some Prospective longer follow-up duration will required exclude confounding confirm these associations.

Language: Английский

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Schizophrenia and Influenza at the Centenary of the 1918-1919 Spanish Influenza Pandemic: Mechanisms of Psychosis Risk

Frontiers in Psychiatry, Journal Year: 2020, Volume and Issue: 11

Published: Feb. 26, 2020

Associations between influenza infection and psychosis have been reported since the eighteenth century, with acute 'psychoses of influenza' documented during multiple pandemics. In late 20th reports a season-of-birth effect in schizophrenia were supported by large-scale ecological sero-epidemiological studies suggesting that maternal increases risk offspring. We examine evidence for association risk, before reviewing possible mechanisms via which this may be conferred. Maternal immune activation models implicate placental dysfunction, disruption cytokine networks subsequent microglial as potentially important pathogenic processes. More recent neuroimmunological advances focusing on neuronal autoimmunity following provide basis model infection-induced psychosis, implicating to schizophrenia-relevant protein targets including N-methyl-D-aspartate receptor. Finally, we outline areas future research relevant experimental approaches consider whether current provides rational development strategies prevent schizophrenia.

Language: Английский

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The fetal inflammatory response syndrome: the origins of a concept, pathophysiology, diagnosis, and obstetrical implications

Seminars in Fetal and Neonatal Medicine, Journal Year: 2020, Volume and Issue: 25(4), P. 101146 - 101146

Published: Aug. 1, 2020

The fetus can deploy a local or systemic inflammatory response when exposed to microorganisms or, alternatively, non-infection-related stimuli (e.g., danger signals alarmins). term "Fetal Inflammatory Response Syndrome" (FIRS) was coined describe condition characterized by evidence of response, frequently result the activation innate limb immune response. FIRS be diagnosed an increased concentration umbilical cord plasma serum acute phase reactants such as C-reactive protein cytokines interleukin-6). Pathologic fetal indicates presence funisitis chorionic vasculitis. first described in patients at risk for intraamniotic infection who presented preterm labor with intact membranes prelabor rupture membranes. However, also observed sterile intra-amniotic inflammation, alloimmunization Rh disease), and active autoimmune disorders. Neonates born have higher rate complications, early-onset neonatal sepsis, intraventricular hemorrhage, periventricular leukomalacia, death, than those without FIRS. Survivors are long-term sequelae that may include bronchopulmonary dysplasia, neurodevelopmental disorders, cerebral palsy, retinopathy prematurity, sensorineuronal hearing loss. Experimental induced administration bacteria, microbial products (such endotoxin), interleukin-1), animal models provided important insights about mechanisms responsible multiple organ involvement dysfunction. A is thought adaptive, but, on occasion, become dysregulated whereby cytokine storm ensues lead dysfunction even death if delivery does not occur ("rescued birth"). Thus, onset this context considered survival value. so far suggests compound effects immaturity thus increasing complications morbidity. Modulation antimicrobial agents, anti-inflammatory cell-based therapy holds promise reduce infant morbidity mortality.

Language: Английский

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COVID-19 in pregnancy: implications for fetal brain development

Trends in Molecular Medicine, Journal Year: 2022, Volume and Issue: 28(4), P. 319 - 330

Published: Feb. 14, 2022

The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection during pregnancy on the developing fetal brain is poorly understood. Other antenatal infections such as influenza have been associated with adverse neurodevelopmental outcomes in offspring. Although vertical transmission has rarely observed SARS-CoV-2 to date, given potential for profound maternal immune activation (MIA), likely. Here we review evidence that and other viral can result maternal, placental, activation, ultimately offspring morbidity. Finally, highlight need cellular models development better understand short- long-term impacts next generation.

Language: Английский

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