Pathogenesis of viral infections during pregnancy DOI
Patrick S. Creisher, Sabra L. Klein

Clinical Microbiology Reviews, Journal Year: 2024, Volume and Issue: 37(2)

Published: Feb. 29, 2024

SUMMARY Viral infections during pregnancy are associated with significant adverse perinatal and fetal outcomes. Pregnancy is a unique immunologic physiologic state, which can influence control of virus replication, severity disease, vertical transmission. The placenta the organ maternal-fetal interface provides defense against microbial infection while supporting semi-allogeneic fetus via tolerogenic immune responses. Some viruses, such as cytomegalovirus, Zika virus, rubella breach these defenses, directly infecting having long-lasting consequences. Even without direct placental infection, other including respiratory viruses like influenza severe acute syndrome coronavirus 2, still cause damage inflammation. Concentrations progesterone estrogens rise contribute to immunological adaptations, placentation, development play pivotal role in creating environment at interface. Animal models, mice, nonhuman primates, rabbits, guinea pigs, instrumental for mechanistic insights into pathogenesis viral identification targetable treatments improve health outcomes pregnant individuals offspring.

Language: Английский

An update on COVID-19 and pregnancy DOI Open Access
Denise J. Jamieson, Sonja A. Rasmussen

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(2), P. 177 - 186

Published: Sept. 14, 2021

Language: Английский

Citations

421
SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis DOI Creative Commons

Agustín Conde‐Agudelo,

Roberto Romero

American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 226(1), P. 68 - 89.e3

Published: July 21, 2021

To examine the relationship between SARS-CoV-2 infection during pregnancy and risk for preeclampsia.

Language: Английский

Citations

248
Association of SARS-CoV-2 Infection With Serious Maternal Morbidity and Mortality From Obstetric Complications DOI Open Access
Torri D. Metz,

Rebecca G. Clifton,

Brenna L. Hughes

et al.

JAMA, Journal Year: 2022, Volume and Issue: 327(8), P. 748 - 748

Published: Feb. 7, 2022

It remains unknown whether SARS-CoV-2 infection specifically increases the risk of serious obstetric morbidity. To evaluate association with maternal morbidity or mortality from common complications. Retrospective cohort study 14 104 pregnant and postpartum patients delivered between March 1, 2020, December 31, 2020 (with final follow-up to February 11, 2021), at 17 US hospitals participating in Eunice Kennedy Shriver National Institute Child Health Human Development's Gestational Research Assessments COVID-19 (GRAVID) Study. All were included compared those without a positive test result who on randomly selected dates over same period. was based nucleic acid antigen result. Secondary analyses further stratified by disease severity. The primary outcome composite death related hypertensive disorders pregnancy, hemorrhage, other than SARS-CoV-2. main secondary cesarean birth. Of (mean age, 29.7 years), 2352 had 11 752 did not have Compared result, significantly associated (13.4% vs 9.2%; difference, 4.2% [95% CI, 2.8%-5.6%]; adjusted relative [aRR], 1.41 1.23-1.61]). 5 deaths group. birth (34.7% 32.4%; aRR, 1.05 0.99-1.11]). moderate higher severity (n = 586) (26.1% 16.9% 13.3%-20.4%]; 2.06 1.73-2.46]) major (45.4% 12.8% 8.7%-16.8%]; 1.17 1.07-1.28]), but mild asymptomatic 1766) (9.2% 0% -1.4% 1.4%]; 1.11 0.94-1.32]) (31.2% -3.6% 0.8%]; 1.00 0.93-1.07]). Among individuals hospitals, an increased for

Language: Английский

Citations

233
Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2 DOI Creative Commons
Valeria Garcia‐Flores, Roberto Romero,

Yi Xu

et al.

Nature Communications, Journal Year: 2022, Volume and Issue: 13(1)

Published: Jan. 18, 2022

Pregnant women represent a high-risk population for severe/critical COVID-19 and mortality. However, the maternal-fetal immune responses initiated by SARS-CoV-2 infection, whether this virus is detectable in placenta, are still under investigation. Here we show that infection during pregnancy primarily induces unique inflammatory at interface, which largely governed maternal T cells fetal stromal cells. also associated with humoral cellular blood, as well mild cytokine response neonatal circulation (i.e., umbilical cord blood), without compromising T-cell repertoire or initiating IgM responses. Importantly, not detected placental tissues, nor sterility of placenta compromised viral infection. This study provides insight into triggered emphasizes rarity

Language: Английский

Citations

184
Pregnancy and birth outcomes after SARS-CoV-2 vaccination in pregnancy DOI Open Access
Regan N. Theiler, Myra J. Wick,

Ramila A. Mehta

et al.

American Journal of Obstetrics & Gynecology MFM, Journal Year: 2021, Volume and Issue: 3(6), P. 100467 - 100467

Published: Aug. 20, 2021

Language: Английский

Citations

170
Adverse Pregnancy Outcomes, Maternal Complications, and Severe Illness Among US Delivery Hospitalizations With and Without a Coronavirus Disease 2019 (COVID-19) Diagnosis DOI Creative Commons
Jean Y. Ko, Carla L. DeSisto, Regina M. Simeone

et al.

Clinical Infectious Diseases, Journal Year: 2021, Volume and Issue: 73(Supplement_1), P. S24 - S31

Published: April 19, 2021

Abstract Background Evidence on risk for adverse outcomes from coronavirus disease 2019 (COVID-19) among pregnant women is still emerging. We examined the association between COVID-19 at delivery and pregnancy outcomes, maternal complications, severe illness, whether these associations differ by race/ethnicity, describe discharge status diagnosis complications. Methods Data 703 hospitals in Premier Healthcare Database during March–September 2020 were included. Adjusted ratios (aRRs) overall stratified race/ethnicity estimated using Poisson regression with robust standard errors. Proportion not discharged home was calculated diagnosis. Results Among 489 471 hospitalizations, 6550 (1.3%) had a In adjusted models, associated increased acute respiratory distress syndrome (aRR, 34.4), death 17.0), sepsis 13.6), mechanical ventilation 12.7), shock 5.1), intensive care unit admission 3.6), renal failure 3.5), thromboembolic 2.7), cardiac event/outcome 2.2), preterm labor 1.2). Risk any complications or illness did significantly race/ethnicity. Discharge COVID-19; however, concurrent greater proportion of those (vs without) home. Conclusions These findings emphasize importance implementing recommended prevention strategies to reduce 2 (SARS-CoV-2) infection further inform counseling clinical pandemic.

Language: Английский

Citations

153
The effect of maternal SARS-CoV-2 infection timing on birth outcomes: a retrospective multicentre cohort study DOI Creative Commons
Samantha N. Piekos, Ryan Roper, Yeon Mi Hwang

et al.

The Lancet Digital Health, Journal Year: 2022, Volume and Issue: 4(2), P. e95 - e104

Published: Jan. 14, 2022

The impact of maternal SARS-CoV-2 infection remains unclear. In this study, we evaluated the risk on birth outcomes and how is modulated by pregnancy trimester in which occurs. We also developed models to predict gestational age at delivery for people following a during pregnancy.

Language: Английский

Citations

110
Clinical risk factors of adverse outcomes among women with COVID-19 in the pregnancy and postpartum period: a sequential, prospective meta-analysis DOI Creative Commons
Emily R. Smith, Erin Oakley, Gargi Wable Grandner

et al.

American Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 228(2), P. 161 - 177

Published: Aug. 24, 2022

Language: Английский

Citations

102
A Prospective Cohort Study of COVID-19 Vaccination, SARS-CoV-2 Infection, and Fertility DOI Creative Commons
Amelia K. Wesselink, Elizabeth E. Hatch, Kenneth J. Rothman

et al.

American Journal of Epidemiology, Journal Year: 2022, Volume and Issue: 191(8), P. 1383 - 1395

Published: Jan. 14, 2022

Some reproductive-aged individuals remain unvaccinated against coronavirus disease 2019 (COVID-19) because of concerns about potential adverse effects on fertility. Using data from an internet-based preconception cohort study, we examined the associations COVID-19 vaccination and severe acute respiratory syndrome 2 (SARS-CoV-2) infection with fertility among couples trying to conceive spontaneously. We enrolled 2,126 self-identified female participants aged 21-45 year residing in United States or Canada during December 2020-September 2021 followed them through November 2021. Participants completed questionnaires every 8 weeks sociodemographics, lifestyle, medical factors, partner information. fit proportional probabilities regression models estimate between self-reported SARS-CoV-2 both partners fecundability (i.e., per-cycle probability conception), adjusting for confounders. was not appreciably associated either (female ratio (FR) = 1.08, 95% confidence interval (CI): 0.95, 1.23; male FR CI: 0.83, 1.10). Female strongly (FR 1.07, 0.87, 1.31). Male a transient reduction (for within 60 days, 0.82, 0.47, 1.45; after 1.16, 0.92, 1.47). These findings indicate that may be short-term decline does impair partner.

Language: Английский

Citations

97
Uptake of COVID-19 Vaccines among Pregnant Women: A Systematic Review and Meta-Analysis DOI Creative Commons
Petros Galanis, Irène Vraka, Όλγα Σίσκου

et al.

Vaccines, Journal Year: 2022, Volume and Issue: 10(5), P. 766 - 766

Published: May 12, 2022

Mass vaccination against COVID-19 is essential to control the pandemic. vaccines are now recommended during pregnancy prevent adverse outcomes. With this review, we aimed evaluate evidence in literature regarding uptake of vaccinations among pregnant women. A comprehensive search was performed PubMed, Medline, Scopus, ProQuest, Web Science, CINAHL, and medRxiv from inception 23 March 2022. We a meta-analysis estimate overall proportion women vaccinated COVID-19. found 11 studies including 703,004 The 27.5% (95% CI: 18.8–37.0%). Predictors were older age, ethnicity, race, trust vaccines, fear pregnancy. Mistrust government, diagnosis pregnancy, fears about safety side effects reasons for declining vaccination. global prevalence low. large gap exists on factors influencing decision be Targeted information campaigns increase vaccine literacy

Language: Английский

Citations

79