Obstetrical & Gynecological Survey, Journal Year: 2022, Volume and Issue: 77(2), P. 80 - 82
Published: Feb. 1, 2022
(Abstracted from JAMA Pediatr 2021;175:817–826) At the beginning of COVID-19 pandemic, extent risks a COVID infection during pregnancy were unknown. During start there only few studies published comparing outcomes between pregnant women with and without infections.
Language: Английский
BMJ, Journal Year: 2020, Volume and Issue: unknown, P. m3320 - m3320
Published: Sept. 1, 2020
Abstract Objective To determine the clinical manifestations, risk factors, and maternal perinatal outcomes in pregnant recently women with suspected or confirmed coronavirus disease 2019 (covid-19). Design Living systematic review meta-analysis. Data sources Medline, Embase, Cochrane database, WHO COVID-19 China National Knowledge Infrastructure (CNKI), Wanfang databases from 1 December to 27 April 2021, along preprint servers, social media, reference lists. Study selection Cohort studies reporting rates, manifestations (symptoms, laboratory radiological findings), covid-19. extraction At least two researchers independently extracted data assessed study quality. Random effects meta-analysis was performed, estimates pooled as odds ratios difference proportions 95% confidence intervals. All analyses are updated regularly. Results 435 were included. Overall, 9% (95% interval 7% 10%; 149 studies, 926 232 women) of attending admitted hospital for any reason diagnosed having The most common covid-19 pregnancy fever cough (both 36%). Compared non-pregnant reproductive age, less likely report symptoms fever, dyspnoea, cough, myalgia. admission an intensive care unit (odds ratio 2.61, 1.84 3.71; I 2 =85.6%), invasive ventilation (2.41, 2.13 2.71; =0%) higher than age. 970 (0.2%, 123 179 981 died cause. In covid-19, non-white ethnicity, increased high body mass index, pre-existing comorbidity including chronic hypertension diabetes, specific complications such gestational diabetes pre-eclampsia, associated serious (severe unit, ventilation, death). without those had death 6.09, 1.82 20.38; =76.6%), (5.41, 3.59 8.14; =57.0%), caesarean section (1.17, 1.01 1.36; =80.3%), preterm birth (1.57, 1.36 1.81; =49.3%). stillbirth (1.81, 1.38 2.37, =0%), neonatal (2.18, 1.46 3.26, =85.4%) babies born versus Conclusion Pregnant hospitals manifest myalgia, but more be needing Pre-existing comorbidities, hypertension, index factors severe pregnancy. deliver have being unit. Their Systematic registration PROSPERO CRD42020178076. Readers’ note This article is a living that will reflect emerging evidence. Updates may occur up years date original publication. version update published on September 2020 ( BMJ 2020;370:m3320), previous updates can found supplements https://www.bmj.com/content/370/bmj.m3320/related#datasupp ). When citing this paper please consider adding number access clarity.
Language: Английский
Citations
2135
JAMA Pediatrics, Journal Year: 2021, Volume and Issue: 175(8), P. 817 - 817
Published: April 22, 2021
Detailed information about the association of COVID-19 with outcomes in pregnant individuals compared not-infected is much needed.
Language: Английский
Citations
1194
American Journal of Obstetrics and Gynecology, Journal Year: 2020, Volume and Issue: 224(1), P. 35 - 53.e3
Published: July 31, 2020
This study aimed to conduct a systematic review of the current literature determine estimates vertical transmission coronavirus disease 2019 based on early RNA detection severe acute respiratory syndrome 2 after birth from various neonatal or fetal sources and serology.Eligible studies published until May 28, 2020, were retrieved PubMed, EMBASE, medRxiv, bioRxiv collection databases.This included cohort studies, case series, reports pregnant women who received diagnosis using viral test had reported data regarding testing neonates fetuses for immediately within 48 hours birth. A total 30 eligible describing 43 tested 38 series 936 included.The methodological quality all was evaluated by modified version Newcastle-Ottawa scale. Quantitative synthesis performed according biological specimen site reach pooled proportions transmission.Our quantitative revealed that mothers with 2019, 27 positive result nasopharyngeal swab, indicating proportion 3.2% (95% confidence interval, 2.2-4.3) transmission. Of note, positivity in swab China 2.0% (8/397), which similar 2.7% (14/517) outside China. Severe cord blood 2.9% samples (1/34), 7.7% placenta (2/26), 0% amniotic fluid (0/51), urine (0/17), 9.7% fecal rectal swabs (3/31). Neonatal serology 3 82 (3.7%) (based presence immunoglobulin M).Vertical is possible seems occur minority cases maternal infection third trimester. The rates are those other pathogens cause congenital infections. However, given paucity trimester data, no assessment can yet be made pregnancy potential risk consequent morbidity mortality.
Language: Английский
Citations
632
Reproductive Health, Journal Year: 2021, Volume and Issue: 18(1)
Published: Jan. 18, 2021
Abstract Introduction The Covid-19 pandemic affects maternal health both directly and indirectly, direct indirect effects are intertwined. To provide a comprehensive overview on this broad topic in rapid format behooving an emergent we conducted scoping review. Methods A review was to compile evidence impacts of the most significant outcomes thus far. Working papers news articles were considered appropriate along with peer-reviewed publications order capture rapidly evolving updates. Literature English published from January 1st September 11 2020 included if it pertained or COVID-19 physical, mental, economic, social wellbeing pregnant people. Narrative descriptions written about subject areas for which authors found evidence. Results search yielded 396 publications, 95 included. Pregnant individuals be at heightened risk more severe symptoms than people who not pregnant. Intrauterine, vertical, breastmilk transmission unlikely. Labor, delivery, breastfeeding guidelines positive patients varied. Severe increases mental issues, such as clinically relevant anxiety depression, reported. Domestic violence appeared spike. Prenatal care visits decreased, healthcare infrastructure strained, potentially harmful policies implemented little Women likely lose their income due men, working mothers struggled increased childcare demands. Conclusion women higher infection pregnant, however symptomatic may experience adverse compared non-pregnant seem face disproportionate socio-economic consequences. High low- middle-income countries alike faced struggles. Further resources should directed towards quality epidemiological studies. Plain summary reproductive perinatal through itself but also indirectly consequence changes care, policy, economic circumstances. consequences have Intrauterine transmission, passage virus mother baby during delivery labor, vary, variability could create uncertainty unnecessary harm. high low/middle countries. impact is marked. frequency problems, epidemic reported many This reflects increase studies demonstrating true change lacking. vulnerable losing We make several recommendations: studies, services diminished, focus needed.
Language: Английский
Citations
602
Physiological Reviews, Journal Year: 2020, Volume and Issue: 101(1), P. 303 - 318
Published: Sept. 24, 2020
There are many unknowns for pregnant women during the coronavirus disease 2019 (COVID-19) pandemic. Clinical experience of pregnancies complicated with infection by other coronaviruses e.g., Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Syndrome, has led to woman being considered potentially vulnerable severe SARS-CoV-2 infection. Physiological changes pregnancy have a significant impact on immune system, respiratory cardiovascular function, coagulation. These may positive or negative effects COVID-19 progression. The in remains be determined, concerted, global effort is required determine implantation, fetal growth development, labor, neonatal health. Asymptomatic presents further challenge regarding service provision, prevention, management. Besides direct impacts disease, plethora indirect consequences pandemic adversely affect maternal health, including reduced access reproductive health services, increased mental strain, socioeconomic deprivation. In this review, we explore current knowledge highlight areas research minimize its their children.
Language: Английский
Citations
583
Proceedings of the National Academy of Sciences, Journal Year: 2021, Volume and Issue: 118(34)
Published: Aug. 10, 2021
Quantification of asymptomatic infections is fundamental for effective public health responses to the COVID-19 pandemic. Discrepancies regarding extent asymptomaticity have arisen from inconsistent terminology as well conflation index and secondary cases which biases toward lower asymptomaticity. We searched PubMed, Embase, Web Science, World Health Organization Global Research Database on between January 1, 2020 April 2, 2021 identify studies that reported silent at time testing, whether presymptomatic or asymptomatic. Index were removed minimize representational bias would result in overestimation symptomaticity. By analyzing over 350 studies, we estimate percentage never developed clinical symptoms, thus truly asymptomatic, was 35.1% (95% CI: 30.7 39.9%). At 42.8% prediction interval: 5.2 91.1%) exhibited no a group comprising both infections. Asymptomaticity significantly among elderly, 19.7% 12.7 29.4%) compared with children 46.7% 32.0 62.0%). also found comorbidities had underlying medical conditions. Without proactive policies detect infections, such rapid contact tracing, prolonged efforts pandemic control may be needed even presence vaccination.
Language: Английский
Citations
463
EClinicalMedicine, Journal Year: 2020, Volume and Issue: 25, P. 100446 - 100446
Published: July 3, 2020
Language: Английский
Citations
352
eLife, Journal Year: 2020, Volume and Issue: 9
Published: July 14, 2020
The pandemic of coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome 2 (SARS-CoV-2) has affected more than 10 million people, including pregnant women. To date, no consistent evidence for vertical transmission SARS-CoV-2 exists. novel canonically utilizes angiotensin-converting enzyme (ACE2) receptor and serine protease TMPRSS2 cell entry. Herein, building upon our previous single-cell study (Pique-Regi et al., 2019), another study, new single-cell/nuclei RNA-sequencing data, we investigated expression ACE2 throughout pregnancy in placenta as well third-trimester chorioamniotic membranes. We report that co-transcription is negligible placenta, thus not a likely path SARS-CoV-2. By contrast, receptors Zika virus cytomegalovirus, which cause congenital infections, are highly expressed placental types. These data show minimally expresses canonical cell-entry mediators
Language: Английский
Citations
263
American Journal of Obstetrics and Gynecology, Journal Year: 2021, Volume and Issue: 225(1), P. 77.e1 - 77.e14
Published: Jan. 27, 2021
Language: Английский
Citations
260
Frontiers in Global Women s Health, Journal Year: 2020, Volume and Issue: 1
Published: Dec. 8, 2020
Even if the fatality rate has been twice higher for men than women, Covid-19 pandemic affected women more men, both as frontline workers and at home. The aim of our article was to analyze differences observed in mental health violence between COVID outbreak. For this purpose, we have used all papers available PubMed January July 2020 well data from non-governmental associations. We thus successively analyzed situation pregnancy during pandemic; specific psychological psychiatric risks faced by patients sector, increased risk against home workplace and, finally run children within their families. In conclusion, research on subject issues is still scarce, especially women. hope that will help recognize major role workplace.
Language: Английский
Citations
231