Antioxidant Properties of Albumin and Diseases Related to Obstetrics and Gynecology

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 55 - 55

Published: Jan. 6, 2025

Albumin, the most abundant protein, contributes significantly to various physiological processes, indicating its multifunctional properties. It has drawn attention of scientists and physicians because primary role in maintaining osmotic pressure involvement transporting numerous small molecules, including hormones, fatty acids, drugs. A growing body evidence recently illustrated an additional aspect albumin’s antioxidant Therefore, based on recent research findings, this review article delves into molecular biochemical aspects antioxidative capabilities. We highlight multifaceted significance proteins oxidative stress their relation pathologies obstetrics gynecology. In particular, we focused preeclampsia, which is closely involved pathogenesis, renal dysfunction leads increased albumin excretion urine, resulting hypoalbuminemia. addition, discussed preeclampsia diagnosis, patient prognosis. Understanding properties opens new avenues for therapeutic intervention sheds light novel strategies combating associated with damage. study, employed PubMed database search articles that assessed albumin, a specific focus obstetric diseases, particularly preeclampsia. The last update was conducted November 2024.

Language: Английский

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Predictive value of prenatal screening markers combined with serum placental growth factor in early pregnancy for preeclampsia

Pakistan Journal of Medical Sciences, Journal Year: 2025, Volume and Issue: 41(2), P. 598 - 602

Published: Jan. 24, 2025

Objective: To observe the predictive value of prenatal screening markers combined with serum placental growth factor(PLGF) in early pregnancy for preeclampsia(PE). Methods: This was a prospective study. A total 369 pregnant women undergoing examinations were selected at Jingmen Central Hospital from August 2024 to January 2025 and divided into PE group(n=43) normal group(n=326) according presence during follow-up. The levels alpha-fetoprotein(AFP), PLGF, β-human chorionic gonadotropin(β-hCG) pregnancy-associated plasma protein-A(PAPP-A) compared between two groups. Results: There 43 patients experiencing PE, an incidence 11.65%. β-hCG PAPP-A significantly decreased group those group, differences groups statistically significant (all P<0.05). Logistic regression analysis showed that increased AFP, HCG independent risk factors Finally, results ROC curve AUCs 0.618, 0.645, 0.690, respectively, AUC prediction 0.825, which each marker alone, differences(P<0.05). Conclusion: development is closely related PAPP-A. efficiency detection increases. Project Title: sFlt-1/PlGF based Nursing Strategies Application Preeclampsia Risk Assessment, Number: 2024YFYB111, Year: 2024. doi: https://doi.org/10.12669/pjms.41.2.9794 How cite this: Shu Z, Wang W. Predictive factor preeclampsia. Pak J Med Sci. 2025;41(2)598-602. Open Access article distributed under terms Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), permits unrestricted use, distribution, reproduction any medium, provided original work properly cited.

Language: Английский

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Aspirin Improves Uterine Artery Function in Hypercholesterolemic Preeclampsia

Hypertension, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

BACKGROUND: Excessive hypercholesterolemia in pregnancy increases the risk of preeclampsia, though mechanisms remain unclear. We recently showed that uterine artery function is impaired hypercholesterolemia-preeclampsia via activation TLR4 (toll-like receptor 4)/PGHS1 (prostaglandin H synthase 1) pathway. Low-dose aspirin lowers preeclampsia high-risk pregnancies by inhibiting PGHS1, but its effects are not known. Moreover, oxidized low-density lipoprotein levels rise hypercholesterolemia-preeclampsia, potentially activating and LOX-1 (lectin-like oxLDL receptor-1; scavenger linked to vascular dysfunction preeclampsia). However, whether this occurs METHODS: Sprague Dawley rats received a control or high-cholesterol diet (to induce hypercholesterolemia-preeclampsia) from gestational day 6 20, with placebo low-dose (1.5 mg/daily) given 10 20. On outcomes were assessed. RESULTS: Uterine blood flow velocity placental weights higher placebo-treated dams versus controls, these reduced aspirin. Endothelium-dependent vasodilation was arteries group controls corrected Ex vivo inhibition TLR4, also normalized endothelium-dependent dams. Exposure bath (modeling secondary hit) further group, partially LOX-1, which prevented CONCLUSIONS: improved endothelial pregnancies; likely suppressing TLR4/LOX-1/PGHS1

Language: Английский

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Evaluating oxidative stress targeting treatments in in vitro models of placental stress relevant to preeclampsia

Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13

Published: Feb. 28, 2025

Preeclampsia is a complex pregnancy disorder characterized by the new onset of hypertension and organ dysfunction, often leading to significant maternal fetal morbidity mortality. Placental dysfunction hallmark feature preeclampsia, which caused inappropriate trophoblast cell function in association with oxidative stress, inflammation and/or pathological hypoxia. This study explores role stress cell-based models mimicking preeclamptic placenta evaluates potential therapeutic strategies targeting these mechanisms. Uric acid (UA) malondialdehyde (MDA) concentrations were measured human plasma from women preeclampsia (n = 24) or normotensive controls 14) using colorimetric assays. Custom-made first trimester line, ACH-3P, was exposed various preeclampsia-like stimuli including hypoxia mimetic (dimethyloxalylglycine DMOG, 1 mM), (tumour necrosis factor TNF-α, 10 ng/mL) mitochondria agent, (Rhodamine-6G Rho-6G, μg/mL), ± aspirin (0.5 metformin AD-01 (100 nM) resveratrol (15 µM), for 48 h. Following treatments, UA/MDA, proliferation (MTT), wound scratch cytometric bead, assays, performed. Overall, MDA concentration increased group compared healthy (p < 0.001) whereas UA showed trend towards an increase 0.06); when adjusted differences gestational age at blood sampling, remained became 0.03) significantly correlated preeclampsia. Our 2D vitro model placental as observed mimicked following treatment DMOG 0.0001), TNF-α 0.05) Rho-6G only presence 0.0001) 0.001). Metformin able abrogate DMOG- 0.01), Rho-6G- TNF-α- 0.01) induced UA, 0.05)induced MDA. abrogated 0.001)/DMOG respectively. The also adverse impact on proliferation, migration inflammation, most restored either aspirin, metformin, resveratrol, 0.05). recapitulate response cells stresses, modelling development, demonstrate repurposed treatments.

Language: Английский

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Early pathways, biomarkers, and four distinct molecular subclasses of preeclampsia: The intersection of clinical, pathological, and high-dimensional biology studies

Placenta, Journal Year: 2022, Volume and Issue: 125, P. 10 - 19

Published: March 21, 2022

Preeclampsia is a syndromic disease of the mother, fetus, and placenta. The main limitation in early accurate diagnosis preeclampsia rooted heterogeneity this syndrome as reflected by diverse molecular pathways, symptoms, clinical outcomes. Gaps our knowledge preclude successful diagnosis, personalized treatment, prevention. advent "omics" technologies systems biology approaches addresses problem identifying pathways associated with underlying mechanisms phenotypes preeclampsia. Here, we provide brief overview on how field has progressed, focusing studies utilizing state-of-the-art transcriptomics proteomics methods. Moreover, summarize involving maternal blood placental transcriptomics, which identified showed that their interaction influences presentation We also present an analysis data revealed distinct subclasses mechanisms. Maternal behind these are similar to those recently reported transcriptome. These findings may promote development novel diagnostic tools for subtypes syndrome, enabling detection follow-up tailored care patients.

Language: Английский

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Differences and similarities in endothelial and angiogenic profiles of preeclampsia and COVID-19 in pregnancy

American Journal of Obstetrics and Gynecology, Journal Year: 2022, Volume and Issue: 227(2), P. 277.e1 - 277.e16

Published: March 26, 2022

COVID-19 presents a spectrum of signs and symptoms in pregnant women that might resemble preeclampsia. Differentiation between severe preeclampsia is difficult some cases.To study biomarkers endothelial damage, coagulation, innate immune response, angiogenesis pregnancy addition to vitro alterations cells exposed sera from with COVID-19.Plasma samples were obtained infection classified into mild (n=10) or (n=9) normotensive pregnancies as controls patients (n=13). A panel plasmatic was assessed, including vascular cell adhesion molecule-1, soluble tumor necrosis factor-receptor I, heparan sulfate, von Willebrand factor antigen (activity multimeric pattern), α2-antiplasmin, C5b9, neutrophil extracellular traps, placental growth factor, fms-like tyrosine kinase-1, angiopoietin 2. In addition, microvascular patients' sera, changes the expression intercellular molecule 1 on membranes release matrix evaluated through immunofluorescence. Changes inflammation signaling pathways also assessed by p38 mitogen-activated protein kinase phosphorylation. Statistical analysis included univariate multivariate methods.Biomarker profiles similar those controls. Both showed significant most circulating distinctive profiles. Whereas exhibited higher concentrations factor-α receptor antigen, reduction compared controls, presented marked increase molecule-1 I (significantly increased COVID-19), striking activity, α2-antiplasmin. As expected, reduced kinase-1 2, very high ratio observed C5b9 traps detected Principal component demonstrated clear separation other groups (first second components explained 42.2% 13.5% variance), mainly differentiated variables related kinase-1. Von revealed absence high-molecular-weight multimers (similar profile disease type 2A), whereas healthy patients, pattern normal. Sera both induced an overexpression culture However, effect less pronounced than COVID-19. Immunoblots lysates Patients statistically different suggesting can activate inflammatory pathways.Although dysfunction, exhibit coagulopathy, angiogenic imbalance could aid differential diagnosis these entities.

Language: Английский

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Associations of maternal and placental extracellular vesicle miRNA with preeclampsia

Frontiers in Cell and Developmental Biology, Journal Year: 2023, Volume and Issue: 11

Published: Feb. 22, 2023

Introduction: Gestational vascular complications (GVCs), including gestational hypertension and preeclampsia, are leading causes of maternal morbidity mortality. Elevated levels extracellular vesicles (EVs), in GVC have been linked to injury. This study aims characterize placental circulating EV miRNA GVCs, explores the involvement EV-miRNA GVC, whether they may be used distinguish between pathologies. Methods: Blood samples were obtained from 15 non-pregnant (NP), 18 healthy-pregnant (HP), 23 women with during third trimester. Placental sections after caesarian section. Platelet-poor-plasma (PPP) pellets characterized: size/concentration, protein content expression measured by nanoparticle tracking analysis, western blot, nano-string technology RT-PCR. The effects EVs on trophoblasts EC evaluated. Results: Higher concentrations observed HP-PPP GVC-PPP ( p &lt; 0.0001) compared NP-PPP. concentration large (&gt;100 nm) was higher PPP HP NP group. pregnant demonstrated lower exosomal markers CD63/CD81 NP-EVs. GVC-EVs expressed more human lactogen (hPL) hormone than HP-EVs, reflecting their origin. Screening miRNAs identified certain that highly only (13%) groups (15%), but not Differences detected hsa-miR-16-5p, hsa-miR-210, hsa-miR-29b-3p. hsa-miR-16-5p hsa-miR-210 low NP, significantly GVC-EVs. Except for hsa-miR-29b-3p, which upregulated no significant differences found other sections. Exposure resulted hsa-miR-29b-3p cells exposed HP-EVs villous trophoblasts, EC. Conclusion: Expression reflects pathophysiological status, while status. These findings suggest involved pathologies origins preeclampsia.

Language: Английский

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Expert review: preeclampsia Type I and Type II

American Journal of Obstetrics & Gynecology MFM, Journal Year: 2023, Volume and Issue: 5(12), P. 101203 - 101203

Published: Oct. 21, 2023

Language: Английский

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Antinuclear antibodies positivity in women in reproductive age: From infertility to adverse obstetrical outcomes – A meta-analysis

Journal of Reproductive Immunology, Journal Year: 2023, Volume and Issue: 155, P. 103794 - 103794

Published: Jan. 3, 2023

Language: Английский

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Iron metabolism and ferroptosis: A pathway for understanding preeclampsia

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 167, P. 115565 - 115565

Published: Sept. 24, 2023

Preeclampsia (PE) is a serious medical condition that poses significant health risk to women and children worldwide, particularly in the middle- low-income countries. It complex syndrome occurs as result of abnormal pregnancy. Hypertension most common symptom PE, with proteinuria specific organ systems detrimental targets. PE's pathogenesis diverse, its symptoms can overlap other diseases. In early pregnancy, when placenta takes over control, oxidative stress may be closely associated ferroptosis, type cell death caused by intracellular iron accumulation. Ferroptosis defined redox-active availability, loss antioxidant capacity phospholipids containing polyunsaturated fatty acids (PUFA) oxidation. Recent studies suggest compelling potential link between ferroptosis PE. this article, we comprehensively review current understanding PE discuss one emerging underlying mechanisms, pathway. We also provide perspective analysis on implications process diagnosis, prevention, treatment preeclampsia. aim bridge gap clinicians basic scientists harmful disease challenge research community put more effort into exciting new area.

Language: Английский

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