Medical Science Monitor,
Journal Year:
2024,
Volume and Issue:
30
Published: Oct. 13, 2024
BACKGROUND
This
study
aimed
to
investigate
the
expression
of
RSPO3
and
ß-catenin
in
preeclampsia
relationship
between
b-catenin
levels
maternal-fetal
outcomes.
MATERIAL
AND
METHODS
We
enrolled
60
pregnant
women
with
without
preeclampsia.
collected
peripheral
blood
from
patients
upon
admission;
placenta
cord
were
after
delivery.
The
maternal
blood,
was
measured.
used
Spearman
method
examine
correlations
clinical
characteristics
RSPO3.
Logistic
regression
modeling
identify
independent
risk
factors
for
RESULTS
decreased
placentas
preeclampsia,
significant
differences
(P<0.05).
group
had
more
adverse
pregnancy
level
negatively
correlated
systolic
pressure
(r=-0.4654,
P<0.001)
diastolic
(r=-0.4617,
(r=-0.5373,
P<0.05)
(r=-0.4898,
blood.
CONCLUSIONS
pressure,
could
be
a
factor
development
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(4), P. 2040 - 2040
Published: Feb. 7, 2024
Preeclampsia
(PE)
is
characterized
by
maternal
hypertension
and
placental
dysfunction,
often
leading
to
fetal
growth
restriction
(FGR).
It
associated
with
an
overexpression
of
the
anti-angiogenic
sFLT1
protein,
which
originates
from
placenta
serves
as
a
clinical
biomarker
predict
PE.
To
analyze
impact
on
function
growth,
we
generated
transgenic
mice
placenta-specific
human
(hsFLT1)
overexpression.
Immunohistochemical,
morphometrical,
molecular
analyses
placentas
14.5
dpc
18.5
were
performed
focus
angiogenesis,
nutrient
transport,
inflammation.
Additionally,
development
upon
hsFLT1
was
investigated.
Dams
exhibited
mild
increase
in
serum
levels
expression
revealed
fetuses
sex-specific
manner.
Male
FGR
expressed
higher
amounts
mRNA
compared
females.
displayed
altered
morphology,
hallmarked
spongiotrophoblast
layer
changes
labyrinthine
vascularization.
Further,
showed
significant
reduction
glycogen
storage
transporter
expression.
Moreover,
signs
hypoxia
inflammation
observed
placentas.
The
spongiotrophoblast-specific
mouse
line
demonstrates
that
low
are
sufficient
induce
alterations
Journal of Pregnancy and Child Health,
Journal Year:
2024,
Volume and Issue:
6(1)
Published: Feb. 29, 2024
Preeclampsia,
which
afflicts
3-5%
of
pregnancies
worldwide,
has
recently
being
recognized
to
be
a
cardio-renal
syndrome,
in
neurologic
complications
contribute
the
morbidity
and
mortality
this
syndrome.
The
precise
pathogenesis
preeclampsia,
itself,
is
not
definitely
elucidated,
but
an
imbalance
angiogenic
&
anti-angiogenic
factors
appear
at
play.
acute
preeclampsia
such
as
seizures,
cerebral
edema,
stroke,
posterior
reversible
leukoencephalopathy
syndrome
(PRES)
are
leading
contributors
obstetric
many
low
middle
some
high
income
countries.
In
addition
these
devastating
complications,
registry
other
long-term
data,
over
recent
decades
now
reveal
that
chronic
cardiovascular
mothers
well
offspring
preeclamptic
also
future
morbidity.
review,
we
evaluate
putative
biophysical
mechanisms
both
mother
child,
clinical
implications
new
findings.
We
outline
rational
monitoring
strategy
for
late
children
born
from
pregnancies.
Preventive
strategies,
encompassing
aspirin,
calcium-vitamin
D
supplementation,
exercise,
pravastatin,
metformin,
offer
insights
into
mitigating
risks.
Active
management,
balancing
antihypertensives
planned
delivery,
appears
yield
positive
outcomes.
Future
pathways
emphasize
advancements
research,
early
predictive
biomarkers,
personalized
therapeutic
approaches,
global
health
initiatives.
role
wearable
devices,
telemedicine,
continuous
maternal-fetal
surveillance
paramount.
Specific
attention
unraveling
neurological
establishing
follow-up
programs
crucial
comprehensive
care.
Journal of Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11(4), P. 42 - 42
Published: Nov. 16, 2023
This
review
focuses
on
SARS-CoV-2
infection
in
placental
and
fetal
tissues.
Viremia
is
rare
infected
pregnant
women,
the
virus
seldom
amplified
from
Definite
probable
requires
demonstration
of
viral
RNA
or
proteins
using
situ
hybridization
(ISH)
immunohistochemistry
(IHC).
Small
subsets
(1.0–7.9%,
median
2.8%)
placentas
SARS-CoV-2-positive
women
showed
definite
accompanied
by
a
characteristic
histopathology
named
placentitis
(SP).
The
conventionally
accepted
histopathological
criteria
for
SP
include
triad
intervillositis,
perivillous
fibrin
deposition,
trophoblast
necrosis.
was
shown
to
be
independent
clinical
severity
infection,
but
associated
with
stillbirth
cases
where
destructive
lesions
affecting
more
than
75%
tissue
resulted
insufficiency
severe
hypoxic–ischemic
injury.
An
association
between
maternal
thrombophilia
subset
cases,
suggesting
synergy
deficient
coagulation
cascade
as
one
mechanisms
pathologic
accumulation
affected
placentas.
tissues
approximately
40%
involvement
demonstrated
ISH
IHC
exceptionally
rare.
pathology
also
includes
chronic
malperfusion
absence
infection.
direct
causation
vascular
placenta
COVID-19
debatable,
common
predispositions
(hypertension,
diabetes,
obesity)
may
play
role.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 23, 2024
Abstract
The
contribution
of
air
pollution
induced
cardio-pulmonary
damage
on
the
development
hypertensive
disorders
pregnancy
and
other
adverse
outcomes
has
gained
increased
attention
as
epidemiological
data
continues
to
highlight
spatiotemporal
trends
related
exposure.
However
clinical
mechanistic
surrounding
gestational
complications
remains
sparse,
necessitating
need
for
use
animal
models
study
these
types
pregnancy.
current
seeks
examine
real-time
effects
mid-gestational
ozone
exposure
maternal
blood
pressure
body
temperature
through
radiotelemetry
in
a
rat
model.
resulted
acute
depression
heart
rate
core
compared
control
animals.
Ozone
exposed
animals
also
presented
with
slight
but
significant
increase
arterial
which
was
perpetuated
until
term.
here
illustrates
feasibility
murine
assess
cardiovascular
caused
by
inhaled
toxicants
during
window
