Asian Journal of Pharmaceutical Sciences,
Journal Year:
2023,
Volume and Issue:
19(1), P. 100883 - 100883
Published: Dec. 29, 2023
Nanoscale
drug
delivery
systems
(nDDS)
have
been
employed
widely
in
enhancing
the
therapeutic
efficacy
of
drugs
against
diseases
with
reduced
side
effects.
Although
several
nDDS
successfully
approved
for
clinical
use
up
to
now,
biological
barriers
between
administration
site
and
target
hinder
wider
adoption
disease
treatment.
Polyethylene
glycol
(PEG)-modification
(or
PEGylation)
has
regarded
as
gold
standard
stabilising
complex
environment.
However,
accelerated
blood
clearance
(ABC)
PEGylated
after
repeated
injections
becomes
great
challenges
their
applications.
Zwitterionic
polymer,
a
novel
family
anti-fouling
materials,
evolved
an
alternative
PEG
due
super-hydrophilicity
biocompatibility.
could
avoid
generation
ABC
phenomenon
exhibit
longer
circulation
time
than
analogues.
More
impressively,
zwitterionic
recently
shown
overcome
multiple
such
nonspecific
organ
distribution,
pressure
gradients,
impermeable
cell
membranes
lysosomal
degradation
without
need
any
chemical
modifications.
The
realization
overcoming
by
may
simplify
current
overly
design
nDDS,
which
facilitate
better
translation.
Herein,
we
summarise
recent
progress
at
various
analyse
underlying
mechanisms.
Finally,
prospects
are
introduced
guide
rational
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
36(4)
Published: Aug. 7, 2023
Abstract
Lipid
nanoparticles
(LNPs)
are
currently
the
most
promising
clinical
nucleic
acids
drug
delivery
vehicles.
LNPs
prevent
degradation
of
cargo
during
blood
circulation.
Upon
entry
into
cell,
specific
components
lipid
can
promote
endosomal
escape
acids.
These
basic
properties
as
acid
carriers.
As
exhibit
hepatic
aggregation
characteristics,
enhancing
targeting
out
liver
is
a
crucial
way
to
improve
administrated
in
vivo.
Meanwhile,
loaded
often
considered
inadequate,
and
therefore,
much
effort
devoted
intracellular
release
efficiency
Here,
different
strategies
efficiently
deliver
from
concluded
their
mechanisms
investigated.
In
addition,
based
on
information
that
trials
or
have
completed
trials,
issues
necessary
be
approached
translation
discussed,
which
it
hoped
will
shed
light
development
LNP
drugs.
Advanced Healthcare Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 10, 2025
Abstract
Gene
therapy
offers
transformative
potential
for
treating
genetic
disorders
by
directly
addressing
the
molecular
root
causes
of
diseases.
However,
primary
challenges
gene
involve
efficient
delivery
therapeutic
material
to
target
cells,
crossing
biological
barriers,
managing
toxicity
and
immune
responses.
Mesoporous
silica
nanoparticles
(MSNs),
due
their
unique
structural
features
have
emerged
as
a
promising
platform
overcome
these
challenges.
In
recent
years,
MSNs
gained
significant
attention
nanocarriers
various
nucleic
acids.
This
review
comprehensively
examines
role
in
therapy,
focusing
on
capabilities
targeted
siRNA,
DNA,
CRISPR‐Cas
systems,
other
therapeutics.
work
explores
modern
advancements
synthesis
functionalization
strategies
impact
modifications
stability,
cellular
uptake,
controlled
release
under
physiological
conditions.
Additionally,
highlights
use
develop
theranostic
where
is
combined
with
diagnostic
imaging
real‐time
monitoring
personalized
treatment
strategies.
Finally,
this
discusses
future
perspectives
delivery,
regulatory
challenges,
enhancing
clinical
translation,
expanding
application
cancers.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(20), P. 12487 - 12487
Published: Oct. 18, 2022
To
improve
liposomes’
usage
as
drug
delivery
vehicles,
cryoprotectants
can
be
utilized
to
prevent
constituent
leakage
and
liposome
instability.
Cryoprotective
agents
(CPAs)
or
protect
liposomes
from
the
mechanical
stress
of
ice
by
vitrifying
at
a
specific
temperature,
which
forms
glassy
matrix.
The
majority
studies
on
demonstrate
that
concentration
cryoprotectant
is
increased,
liposomal
stability
improves,
resulting
in
decreased
aggregation.
effectiveness
CPAs
maintaining
aqueous
state
essentially
depends
complex
interaction
between
protectants
bilayer
composition.
Furthermore,
different
types
have
distinct
effective
mechanisms
action;
therefore,
combination
several
may
beneficial
novel
attributed
synergistic
actions
CPAs.
In
this
review,
we
discuss
use
phospholipid–CPA
interactions,
their
thermotropic
behavior
during
freezing,
CPA
mechanism
for
preventing
drugs
liposomes.
Pharmaceutics,
Journal Year:
2022,
Volume and Issue:
14(4), P. 821 - 821
Published: April 8, 2022
Cancer
is
the
second
most
frequent
cause
of
death
worldwide,
with
28.4
million
new
cases
expected
for
2040.
Despite
de
advances
in
treatment,
it
remains
a
challenge
because
tumor
heterogenicity
and
increase
multidrug
resistance
mechanisms.
Thus,
gene
therapy
has
been
potential
therapeutic
approach
owing
to
its
ability
introduce,
silence,
or
change
content
human
genetic
code
inhibiting
progression,
angiogenesis,
metastasis.
For
proper
delivery
genes
cells,
requires
use
vectors
protecting
transporting
into
cells.
Among
these
vectors,
liposomes
have
nonviral
vector
used
their
low
immunogenicity
toxicity.
Furthermore,
this
nanosystem
can
surface
modified
ligands
(e.g.,
antibodies,
peptides,
aptamers,
folic
acid,
carbohydrates,
others)
that
be
recognized
high
specificity
affinity
by
receptor
overexpressed
increasing
selective
tumors.
In
context,
present
review
address
discuss
main
targeting
functionalize
improving
application
cancer
treatment.
Drug Delivery and Translational Research,
Journal Year:
2023,
Volume and Issue:
13(11), P. 2719 - 2738
Published: June 10, 2023
Abstract
The
burden
of
cancer
is
increasing
globally.
Several
challenges
facing
its
mainstream
treatment
approaches
have
formed
the
basis
for
development
targeted
delivery
systems
to
carry
and
distribute
anti-cancer
payloads
their
defined
targets.
This
site-specific
drug
molecules
gene
selectively
target
druggable
biomarkers
aimed
at
inducing
cell
death
while
sparing
normal
cells
principal
goal
therapy.
An
important
advantage
a
vector
either
viral
or
non-viral
cumulative
ability
penetrate
haphazardly
arranged
immunosuppressive
tumour
microenvironment
solid
tumours
withstand
antibody-mediated
immune
response.
Biotechnological
incorporating
rational
protein
engineering
which
may
serve
as
vehicles
packaging
distribution
agents
kill
are
highly
desired.
Over
years,
these
chemically
genetically
modified
selective
accumulation
receptor
sites
resulting
in
constant
maintenance
high
bioavailability
effective
anti-tumour
activity.
In
this
review,
we
highlighted
state-of-the
art
those
under
developments
focusing
on
Graphical
International Journal of Nanomedicine,
Journal Year:
2024,
Volume and Issue:
Volume 19, P. 2441 - 2467
Published: March 1, 2024
Abstract:
New
nanotechnology
strategies
for
enhancing
drug
delivery
in
brain
disorders
have
recently
received
increasing
attention
from
designers.
The
treatment
of
neurological
conditions,
including
tumors,
stroke,
Parkinson's
Disease
(PD),
and
Alzheimer's
disease
(AD),
may
be
greatly
influenced
by
nanotechnology.
Numerous
studies
on
neurodegeneration
demonstrated
the
effective
application
nanomaterials
illnesses.
Nanocarriers
(NCs)
made
it
easier
to
deliver
drugs
precisely
where
they
are
needed.
Thus,
most
use
is
various
diseases,
as
this
amplifies
overall
impact
medication
emphasizes
significance
nanotherapeutics
through
gene
therapy,
enzyme
replacement
blood-barrier
mechanisms.
Recent
advances
led
development
multifunctional
nanotherapeutic
agents,
a
promising
disorders.
This
novel
method
reduces
side
effects
improves
outcomes.
review
critically
assesses
efficient
nano-based
systems
light
obstacles
outstanding
achievements.
that
transfer
medications
across
blood-brain
barrier
nano-assisted
therapies,
nano-immunotherapy,
nano-gene
nano
scaffolds,
3D
6D
printing,
been
widely
explored
study
aimed
evaluate
existing
literature
regarding
can
penetrate
(BBB)
therapeutic
agents
treat
Keywords:
delivery,
nanomedicine,
nano-therapeutics,
nanocarriers,
Virology Journal,
Journal Year:
2024,
Volume and Issue:
21(1)
Published: Jan. 12, 2024
Primary
liver
cancer,
which
is
scientifically
referred
to
as
hepatocellular
carcinoma
(HCC),
a
significant
concern
in
the
field
of
global
health.
It
has
been
demonstrated
that
conventional
chemotherapy,
chemo-hormonal
therapy,
and
conformal
radiotherapy
are
ineffective
against
HCC.
New
therapeutic
approaches
thus
urgently
required.
Identifying
single
or
multiple
mutations
genes
associated
with
invasion,
metastasis,
apoptosis,
growth
regulation
resulted
more
comprehensive
comprehension
molecular
genetic
underpinnings
malignant
transformation,
tumor
advancement,
host
interaction.
This
enhanced
notably
propelled
development
novel
agents.
Therefore,
gene
therapy
(GT)
holds
great
promise
for
addressing
urgent
need
innovative
treatments
However,
complexity
HCC
demands
precise
effective
approaches.
The
adeno-associated
virus
(AAV)
distinctive
life
cycle
ability
persistently
infect
dividing
nondividing
cells
have
rendered
it
an
alluring
vector.
Another
appealing
characteristic
wild-type
its
evident
absence
pathogenicity.
As
result,
AAV,
vector
lacks
envelope
can
be
modified
transport
DNA
specific
cells,
garnered
considerable
interest
scientific
community,
particularly
experimental
strategies
still
clinical
stage.
AAV
vectors
emerge
promising
tools
due
their
non-immunogenic
nature,
efficient
cell
entry,
prolonged
expression.
While
AAV-mediated
GT
demonstrates
across
diverse
diseases,
current
ongoing
trials
targeting
underscores
untapped
potential
this
context.
Furthermore,
transfer
through
hepatic
frequently
facilitated
by
research,
several
congenital
anomalies
affecting
liver.
Notwithstanding
enthusiasm
notion,
recent
discoveries
expose
integration
genome
at
double-strand
breaks
give
rise
apprehensions
regarding
enduring
safety
effectiveness.
review
explores
versatile
targeted
In
summation,
we
encapsulate
multifaceted
exploration
GT,
underlining
transformative
within
landscape
oncology
human
