Research progress of organic photothermal agents delivery and synergistic therapy systems

Colloids and Surfaces B Biointerfaces, Journal Year: 2024, Volume and Issue: 234, P. 113743 - 113743

Published: Jan. 5, 2024

Language: Английский

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A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Aggregate, Journal Year: 2024, Volume and Issue: 5(2)

Published: Jan. 4, 2024

Abstract The development of efficient drug delivery systems is essential for improving the efficacy and safety cancer drugs, particularly aggressive difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in (DDS), due to their unique properties, including metal‐free skeleton, predetermined structures pore geometries, high porosity, large surface area, facile modification potential, good biocompatibility. These characteristics make COFs excellent candidates by enhancing loading capacity enabling precise encapsulation. This review emphasizes importance donor‐acceptor‐based COFs, which provide channels charge transportation, we also explore how π‐conjugated skeleton enhances its long‐acting fluorescent properties facilitates uptake via cell endocytosis. While this primarily focuses on recent advancements COF‐based targeted DDS, it acknowledges challenges posed diverse geometries materials discusses potential solutions. Further, underlines developing future carriers that can successfully specifically target cells, treatment efficiency while reducing adverse side effects.

Language: Английский

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Applications and Enhancement Strategies of ROS-based Non-invasive Therapies in Cancer Treatment

Redox Biology, Journal Year: 2025, Volume and Issue: unknown, P. 103515 - 103515

Published: Jan. 1, 2025

Language: Английский

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Photodynamic Therapy: From the Basics to the Current Progress of N-Heterocyclic-Bearing Dyes as Effective Photosensitizers

Molecules, Journal Year: 2023, Volume and Issue: 28(13), P. 5092 - 5092

Published: June 29, 2023

Photodynamic therapy, an alternative that has gained weight and popularity compared to current conventional therapies in the treatment of cancer, is a minimally invasive therapeutic strategy generally results from simultaneous action three factors: molecule with high sensitivity light, photosensitizer, molecular oxygen triplet state, light energy. There much be said about each these elements; however, efficacy photosensitizer most determining factor for success this modality. Porphyrins, chlorins, phthalocyanines, boron-dipyrromethenes, cyanines are some N-heterocycle-bearing dyes’ classes biological promise. In review, concise approach taken other families potential photosensitizers modifications have recently appeared literature within scope their photodynamic application, as well how compounds formulations may eventually overcome deficiencies molecules currently clinically used revolutionize eradicate or delay growth tumor cells.

Language: Английский

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Nanoparticle-mediated synergistic anticancer effect of ferroptosis and photodynamic therapy: novel insights and perspectives

Asian Journal of Pharmaceutical Sciences, Journal Year: 2023, Volume and Issue: 18(4), P. 100829 - 100829

Published: July 1, 2023

Current antitumor monotherapy has many limitations, highlighting the need for novel synergistic anticancer strategies. Ferroptosis is an iron-dependent form of nonapoptotic cell death that plays a pivotal regulatory role in tumorigenesis and treatment. Photodynamic therapy (PDT) causes irreversible chemical damage to target lesions widely used therapy. However, PDT's effectiveness usually hindered by several obstacles, such as hypoxia, excess glutathione (GSH), tumor resistance. improves efficacy PDT increasing oxygen reactive species (ROS) or reducing GSH levels, also enhances ferroptosis induction due ROS effect microenvironment (TME). Strategies based on nanoparticles (NPs) can subtly exploit potential synergy PDT. This review explores recent advances current challenges landscape underlying mechanisms regulating PDT, well nano delivery system-mediated activity. These include polymers, biomimetic materials, metal organic frameworks (MOFs), inorganics, carrier-free NPs. Finally, we highlight future perspectives this emerging paradigm targeted cancer therapies.

Language: Английский

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Multifunctional nano MOF drug delivery platform in combination therapy

European Journal of Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 261, P. 115884 - 115884

Published: Oct. 16, 2023

Language: Английский

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A NRF2 Regulated and the Immunosuppressive Microenvironment Reversed Nanoplatform for Cholangiocarcinoma Photodynamic‐Gas Therapy

Advanced Science, Journal Year: 2024, Volume and Issue: 11(14)

Published: Feb. 2, 2024

Abstract Photodynamic therapy (PDT) is a minimally invasive and controllable local cancer treatment for cholangiocarcinoma (CCA). However, the efficacy of PDT hindered by intratumoral hypoxia presence an antioxidant microenvironment. To address these limitations, combining with gas may be promising strategy to enhance tumor oxygenation. Moreover, augmentation oxidative damage induced can achieved inhibiting NRF2, core regulatory molecule involved in response. In this study, integrated nanotherapeutic platform called CMArg@Lip, incorporating therapies using ROS‐responsive liposomes encapsulating photosensitizer Ce6, NO gas‐generating agent L‐arginine, NRF2 inhibitor ML385, successfully developed. The utilization CMArg@Lip effectively deals challenges posed microenvironment, resulting elevated levels subsequent induction ferroptosis CCA. Additionally, findings suggest that exhibits notable immunomodulatory effects, including promotion immunogenic cell death facilitation dendritic maturation. Furthermore, it contributes anti‐tumor function cytotoxic T lymphocytes through downregulation PD‐L1 expression cells activation STING signaling pathway myeloid‐derived suppressor cells, thereby reprogramming immunosuppressive microenvironment via various mechanisms.

Language: Английский

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Tumor microenvironment-activated and near-infrared light-driven free radicals amplifier for tetra-modal cancer imaging and synergistic treatment

Journal of Colloid and Interface Science, Journal Year: 2025, Volume and Issue: 689, P. 137208 - 137208

Published: March 1, 2025

Language: Английский

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Co-delivery of Zn ions and resveratrol via bioactive glass-integrated injectable microspheres for postoperative regeneration of bone tumor defects

Composites Part B Engineering, Journal Year: 2024, Volume and Issue: 272, P. 111220 - 111220

Published: Jan. 11, 2024

Language: Английский

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Prostate-Specific Membrane Antigen-Targeted NIR Phototheranostics for Prostate Cancer

ACS Applied Bio Materials, Journal Year: 2024, Volume and Issue: 7(9), P. 5861 - 5884

Published: Aug. 28, 2024

The evolution of targeted cancer theranostics has revolutionized personalized medicine by integrating diagnostic and therapeutic capabilities. Prostate-specific membrane antigen (PSMA) emerged as a key theranostic target in the context prostate cancer, paving way for clinical approval multiple drugs. However, persistent challenge off-target toxicity, which plagues both conventional advanced treatment modalities such chemotherapy radiotherapy, thus demands further innovation. Considering this critical issue, review discusses recent advances binary techniques, i.e., phototherapies, that have potential to circumvent concern toxicity associated with radiotherapy. Precisely, an up-to-date overview latest developments near-infrared (NIR)-based phototheranostic strategies targeting PSMA been presented. Furthermore, we discussed particulars require specific attention enhancing translational techniques.

Language: Английский

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