International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138273 - 138273
Published: Dec. 1, 2024
Language: Английский
Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15
Published: Sept. 30, 2024
Cancer, the world’s second leading cause of death after cardiovascular diseases, is characterized by hallmarks such as uncontrolled cell growth, metastasis, angiogenesis, hypoxia, and resistance to therapy. Autophagy, a cellular process that can both support inhibit cancer progression, plays critical role in development progression. This involves formation autophagosomes ultimately fuse with lysosomes degrade components. A key regulator this Sirtuin 1 (SIRT1), which significantly influences autophagy. review delves into SIRT1 modulating autophagy its broader impacts on carcinogenesis. regulates crucial mediators, AMP-activated protein kinase (AMPK) mammalian target rapamycin (mTOR), effectively promoting or suppressing Beyond direct effects autophagy, SIRT1’s regulatory actions extend other processes, including apoptosis ferroptosis, thereby influencing tumor proliferation, chemotherapy responses. These insights underscore complex interplay between significant implications for Targeting associated pathways presents promising strategy manipulate treatment. underscores potential therapeutic target, opening new avenues enhancing treatment efficacy.
Language: Английский
Citations
3
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 131, P. 111822 - 111822
Published: March 18, 2024
Previous study has indicated that Celastrol (Cel) various physiological and pharmacological effects, including antibacterial, antioxidant, pro-apoptotic, anticancer anti-rheumatoid arthritis (RA) effects. However, low water solubility, oral bioavailability, narrow treatment window, high incidence of systemic adverse reactions still limit the further clinical application Cel. Here, aiming at effectively overcome those shortcomings Cel to boost its beneficial effects for treating RA, we developed leukosome (LEUKO) coated biomimetic nanoparticles (NPs) targeted delivery injury area in RA. LEUKO were synthesized using membrane proteins purified from activated J774 macrophage. Cel-loaded (Cel@LEUKO) characterized dynamic light scattering transmission electron microscopy. Our results demonstrated Cel@LEUKO can inhibit inflammatory response lipopolysaccharide (LPS) induced mouse monocyte macrophage leukemia cells (RAW264.7 cells) human rheumatoid synovial fibroblasts (MH7A) through inhibition reactive oxygen species (ROS)-NF-κB pathway. In addition, research shown targets transports site increased drug concentration affected areas, reduced toxicity Cel, symptoms, infiltration, bone erosion, serum factors collagen-induced (CIA) rats.
Language: Английский
Citations
2
European Journal of Chemistry, Journal Year: 2024, Volume and Issue: 15(2), P. 194 - 204
Published: June 30, 2024
Tripterygium wilfordii (TRWI), known as 'Thunder of God Vine' or 'Lei Gong Teng' in traditional Chinese medicine (TCM), is a perennial vine that has been used for centuries its potent therapeutic properties. This plant, which belongs to the Celastraceae family, documented various TCM texts, where it attributed with wide range benefits, including anti-inflammatory, antirheumatic, and anti-autoimmune activities. Central medicinal potential TRWI celastrol, triterpenoid extensive pharmacological Research on celastrol revealed effects combating inflammation, oxidative stress, cancer proliferation, neurological disorders. However, celastrol’s high toxicity, low water solubility, limited stability pose challenges clinical application. In this review, we explore chemical structure emphasizing key activities structure-activity relationships (SARs) influence efficacy toxicity. Various studies have demonstrated modifications at specific sites, such C-29 carboxylic group, C-6, C-3, can enhance while reducing adverse effects. Moreover, recent advances drug delivery systems offer promising avenues overcome inherent limitations celastrol. These include direct PEGylation indirect through encapsulation dendritic polymers, phytosomes, liposomes, exosomes. Each method seeks improve bioavailability, target capabilities, thus enhancing viability. The objective review synthesize current knowledge about discuss future development pharmaceutical applications. findings could open door new treatment methods combine remedies modern pharmacology, helping us unlock complete use.
Language: Английский
Citations
1
Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3121 - 3141
Published: July 1, 2024
As a traditional Chinese medicine monomer derived from Tripterygium wilfordii Hook.f. with potential anticancer activity, celastrol can induce ferroptosis in hepatic stellate cells and inhibit their activation to alleviate liver fibrosis. Activation of effectively Hepatocellular carcinoma (HCC). Whether inhibits HCC by inducing remains be studied.
Language: Английский
Citations
1
International Journal of Biological Sciences, Journal Year: 2024, Volume and Issue: 20(12), P. 4601 - 4617
Published: Jan. 1, 2024
Celastrol (Cel), derived from the traditional herb
Language: Английский
Citations
1
Phytomedicine, Journal Year: 2024, Volume and Issue: 135, P. 156031 - 156031
Published: Sept. 13, 2024
Previous research demonstrated the effects of Sorbaria sorbifolia (SS) in combating hepatocellular carcinoma (HCC). Despite SS's proven efficacy treating HCC, precise bioactive constituents contributing to its therapeutic benefits, along with mechanisms behind them, warrant further exploration.
Language: Английский
Citations
1
Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(11), P. 1382 - 1382
Published: Oct. 27, 2024
Background/Objectives: Breast cancer, a leading health threat affecting millions worldwide, requires effective therapeutic interventions. Celastrol (CEL), despite its antitumor potential, is limited by poor solubility and stability. This study aimed to enhance CEL’s efficacy encapsulating it within glycyrrhizic acid (GA)-modified lipid calcium carbonate (LCC) nanoparticles for targeted breast cancer therapy. Methods: The 4T1 mouse cells were used the study. GA-LCC-CEL prepared using gas diffusion method thin-film dispersion method. characterized zeta-potential, dynamic light scattering transmission electron microscope (TEM). in vitro release behavior of was assessed dialysis Cellular uptake examined flow cytometry confocal microscopy. Intracellular ROS Rhodamine 123 levels observed under fluorescence MTT colony formation assays cytotoxicity proliferation, apoptosis analyzed Annexin V-FITC/PI staining. Wound healing transwell evaluated migration, Western blotting confirmed protein expression changes related migration. Results: displayed well-defined core-shell structure with uniform size distribution. They showed enhanced anti-proliferative pro-apoptotic effects against significantly reduced cell invasion Additionally, modulated epithelial-mesenchymal transition (EMT) expression, downregulating Snail ZEB1, upregulating E-cadherin. Conclusions: represent promising drug delivery approach enhancing potentially inhibiting progression modulating EMT-related proteins.
Language: Английский
Citations
1
Published: Jan. 1, 2024
Language: Английский
Citations
0
International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: unknown, P. 138273 - 138273
Published: Dec. 1, 2024
Language: Английский
Citations
0