Translational Vision Science & Technology,
Journal Year:
2024,
Volume and Issue:
13(10), P. 26 - 26
Published: Oct. 16, 2024
Choroidal
dysfunction
is
implicated
in
various
ocular
pathologies.
The
parasympathetic
pterygopalatine
ganglion
(PPG)
innervates
orbital
vessels
supplying
the
choroid.
While
PPG
stimulation
has
been
shown
to
dilate
cerebral
blood
flow,
its
effects
on
choroid,
particularly
human
subjects,
require
further
elucidation.
This
study
aimed
investigate
short-term
influence
of
via
electroacupuncture
choroidal
structure.
American Journal of Ophthalmology,
Journal Year:
2024,
Volume and Issue:
268, P. 76 - 85
Published: July 31, 2024
PurposeTo
explore
the
correlation
between
cardiovascular
health
(CVH)
and
ocular
diseases,
given
their
shared
risk
factors
biological
mechanisms,
this
study
utilizes
newly
updated
Life's
Essential
8
(LE8)
algorithm.DesignA
cross-sectional
study.MethodsThis
analysis,
conducted
from
February
15
to
April
1,
2024,
in
Changchun,
includes
data
4,146
participants
aged
40
above,
drawn
National
Health
Nutrition
Examination
Survey
database
(2005-2008).
It
covers
information
on
visual
status,
dietary
habits
through
interviews,
professional
ophthalmological
examinations.
Participants'
CVH
status
was
assessed
using
LE8
algorithm,
relationships
with
major
diseases
such
as
retinopathy,
cataracts,
diabetic
retinopathy
(DR),
glaucoma,
age-related
macular
degeneration
were
explored
weighted
logistic
regression
restricted
cubic
splines,
stratified
sensitivity
analysis.ResultsAfter
multivariable
adjustment,
lower
scores
showed
a
significant
positive
relationship
any
disease
(OR:
2.03,
95%
CI:
1.39-2.96,
p=.001),
objectively
determined
2.24,
1.48-3.38,
p<.001),
2.88,
1.89-4.41,
DR
10.23,
3.11-33.61,
glaucoma
2.76,
1.47-5.21,
p=.003),
all
trends
significant(all
p<.01).
Additionally,
behavioral
subdomain
significantly
correlated
an
elevated
of
cataracts
1.45,
1.03-2.04).
Subgroup
analyses
revealed
more
pronounced
negative
correlations
among
females
those
suffering
chronic
kidney
disease.ConclusionA
low
score
linked
increased
likelihood
US-populated-based
study.
This
supports
potential
benefits
enhancing
wellness
mitigate
development
conditions.
Biomedicines,
Journal Year:
2025,
Volume and Issue:
13(2), P. 365 - 365
Published: Feb. 5, 2025
Eye
diseases
can
significantly
affect
the
quality
of
life
patients
due
to
decreased
visual
acuity.
Although
modern
ophthalmological
diagnostic
methods
exist,
some
system
are
asymptomatic
in
early
stages.
Most
seek
advice
from
an
ophthalmologist
as
a
result
rapidly
progressive
manifestation
symptoms.
A
number
inherited
and
acquired
eye
have
only
supportive
treatment
without
eliminating
etiologic
factor.
promising
solution
this
problem
may
be
gene
therapy,
which
has
proven
efficacy
safety
shown
clinical
studies.
By
directly
altering
or
replacing
defective
genes,
therapeutic
approach
will
stop
well
reverse
progression
diseases.
This
review
examines
concept
therapy
its
application
field
ocular
pathologies,
emphasizing
most
recent
scientific
advances
their
potential
impacts
on
function
status.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 1, 2025
Abstract
In
this
study,
we
investigated
the
influences
of
retinal
structural
changes
on
photopic
and
scotopic
visual
functions.
Participants
aged
55
years
or
over
with
early
intermediate
age-related
macular
degeneration
(AMD)
in
at
least
one
eye,
controls
healthy
maculae
were
included.
Associations
between
functions
using
linear
regression
survival
analysis
all
participants.
Additional
multivariable
analyses
also
performed
control
group
AMD
group.
We
found
that
presence
refractile
drusen
nascent
geographic
atrophy
(nGA)
associated
poorer
BCVA,
LLVA,
increased
LLD
(P
<
0.05).
analysis,
eyes
thicker
subfoveal
choroidal
thickness
(SFCT)
had
a
higher
hazard
rate
rod
intercept
(hazard
ratio,
HR
=
1.287),
suggesting
decreased
RIT.
Eyes
nGA
(HR
0.260),
0.208),
0.126),
SDD
0.157)
have
significantly
lower
(i.e.
RIT,
P
Among
them,
thinner
SFCT
1.229),
0.421),
0.167)
identified
as
independent
factors
an
RIT
final
multivariate
model
Given
associations
outer
layers
established
precursors
progression
to
advanced
AMD,
our
findings
serve
strong
foundation
for
future
investigations
into
relationships
phenotypes
functional
changes.
Diagnostics,
Journal Year:
2024,
Volume and Issue:
14(7), P. 764 - 764
Published: April 3, 2024
The
imagistic
evaluation
of
non-neovascular
age-related
macular
degeneration
(AMD)
is
crucial
for
diagnosis,
monitoring
progression,
and
guiding
management
the
disease.
Dry
AMD,
characterized
primarily
by
presence
drusen
retinal
pigment
epithelium
atrophy,
requires
detailed
visualization
structure
to
assess
its
severity
progression.
Several
imaging
modalities
are
pivotal
in
including
optical
coherence
tomography,
fundus
autofluorescence,
or
color
photography.
In
context
emerging
therapies
geographic
like
pegcetacoplan,
it
critical
establish
baseline
status
disease,
monitor
development
expansion
evaluate
retina’s
response
potential
treatments
clinical
trials.
present
review,
while
initially
providing
a
comprehensive
description
pathophysiology
involved
aims
offer
an
overview
employed
AMD.
Special
emphasis
placed
on
assessment
progression
biomarkers
as
discerned
through
tomography.
As
landscape
AMD
treatment
continues
evolve,
advanced
techniques
will
remain
at
forefront,
enabling
clinicians
most
effective
tailored
their
patients.
Biomolecules,
Journal Year:
2024,
Volume and Issue:
14(3), P. 341 - 341
Published: March 12, 2024
Sterol
homeostasis
in
mammalian
cells
and
tissues
involves
balancing
three
fundamental
processes:
de
novo
sterol
biosynthesis;
import
(e.g.,
from
blood-borne
lipoproteins);
export.
In
complex
tissues,
composed
of
multiple
different
cell
types
(such
as
the
retina),
export
also
may
involve
intratissue,
intercellular
exchange.
Disruption
any
these
processes
can
result
pathologies
that
impact
normal
structure
function
retina.
Here,
we
provide
a
brief
overview
what
is
known
currently
about
vertebrate
retina
offer
proposed
path
for
future
experimental
work
to
further
our
understanding
processes,
with
relevance
development
novel
therapeutic
interventions
human
diseases
involving
defective
homeostasis.
Sterol
homeostasis
in
mammalian
cells
and
tissues
involves
balancing
three
fundamental
processes:
de
novo
sterol
biosynthesis;
import
(e.g.,
from
blood-borne
lipoproteins);
export.
In
complex
tissues,
composed
of
multiple
different
cell
types
(such
as
the
retina),
export
also
may
involve
intra-tissue,
inter-cellular
exchange.
Disruption
any
these
processes
can
result
pathologies
that
impact
normal
structure
function
retina.
Here,
we
provide
a
brief
overview
what
is
known
currently
about
vertebrate
retina
offer
proposed
path
for
future
experimental
work
to
further
our
understanding
processes,
with
relevance
development
novel
therapeutic
interventions
human
diseases
involving
defective
homeostasis.
Sterol
homeostasis
in
mammalian
cells
and
tissues
involves
balancing
three
fundamental
processes:
de
novo
sterol
biosynthesis;
import
(e.g.,
from
blood-borne
lipoproteins);
export.
In
complex
tissues,
composed
of
multiple
different
cell
types
(such
as
the
retina),
export
also
may
involve
intra-tissue,
inter-cellular
exchange.
Disruption
any
these
processes
can
result
pathologies
that
impact
normal
structure
function
retina.
Here,
we
provide
a
brief
overview
what
is
known
currently
about
vertebrate
retina
offer
proposed
path
for
future
experimental
work
to
further
our
understanding
processes,
with
relevance
development
novel
therapeutic
interventions
human
diseases
involving
defective
homeostasis.
