Mannose coated selenium nanoparticles normalize intestinal homeostasis in mice and mitigate colitis by inhibiting NF-κB activation and enhancing glutathione peroxidase expression DOI Creative Commons
Hui Yang, Zhiyao Wang,

Lixin Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 10, 2024

Impaired intestinal homeostasis is a major pathological feature of inflammatory bowel diseases (IBD). Mannose and selenium (Se) both demonstrate potential anti-inflammatory anti-oxidative properties. However, most lectin receptors bind free monosaccharide ligands with relatively low affinity Se species induce side effects beyond very narrow range dosage. This has contributed to poorly explored therapies for IBD that combine mannose target epithelial cells (IECs) normalization gut homeostasis. Herein, facile safe strategy ulcerative colitis (UC) treatment was developed using optimized, mannose-functionalized nanoparticles (M-SeNPs) encapsulated within colon-targeted hydrogel delivery system containing alginate (SA) chitosan (CS). biocompatible nanosystem efficiently taken up by IECs led increased expression Se-dependent glutathione peroxidases (GPXs), thereby modulating IECs' immune response. Using mouse model DSS-induced colitis, (CS/SA)-embedding M-SeNPs (C/S-MSe) were found mitigate oxidative stress inflammation through the inhibition NF-kB pathway in colon. stabilized mucosal ameliorated colitis-related symptoms, providing new approach IBD.

Language: Английский

Reactive Oxygen Species‐Activated CO Versatile Nanomedicine with Innate Gut Immune and Microbiome Remodeling Effects for Treating Inflammatory Bowel Disease DOI

Youyun Zeng,

Meng‐Ni Fan, Qiang Zhou

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(49)

Published: July 28, 2023

Abstract Abnormal activation of the gut mucosal immune system and a highly dysregulated microbiota play essential roles in progression inflammatory bowel disease (IBD). The clinical treatment IBD remains challenging, with first‐line drugs showing limited efficacy significant side effects. A reactive oxygen species (ROS)‐activated CO versatile nanomedicine (CMPs) capable remodeling immune‐microbiota microenvironment via potent anti‐oxidant, anti‐inflammatory, antimicrobial effects is developed. CORM‐401‐loaded mannose‐modified peptide dendrimer nanogel: CMPs preferentially congregate on surface damaged colon mucosa after rectal administration are subsequently internalized by activated cells. CORM‐401 can release numerous molecules response to high ROS levels cells at site IBD, resulting multiple therapeutic In vitro vivo studies have demonstrated that scavenge ROS, suppress responses, eliminate pathogens, alleviate colitis mouse models. RNA sequencing reveals successfully remodel homeostasis scavenging inhibiting NF‐κB/p38MAPK, activating PI3K‐Akt, HIF‐1‐induced glycolysis. 16S ribosomal shows flora composition restraining detrimental bacteria augmenting beneficial bacteria. This study develops promising for management IBD.

Language: Английский

Citations

45
Advances in Engineered Macrophages: A New Frontier in Cancer Immunotherapy DOI Creative Commons
Shuaixi Yang, Yuhang Wang,

Jiachi Jia

et al.

Cell Death and Disease, Journal Year: 2024, Volume and Issue: 15(4)

Published: April 1, 2024

Abstract Macrophages, as pivotal cells within the tumour microenvironment, significantly influence impact of and reactions to treatments for solid tumours. The rapid evolution bioengineering technology has revealed vast potential engineered macrophages in immunotherapy, disease diagnosis, tissue engineering. Given this landscape, goal harnessing innovating a novel strategy immunotherapy cannot be overstated. diverse strategies realm cancer encompassing macrophage drug delivery systems, chimeric antigen receptor therapy, synergistic treatment approaches involving bacterial outer membrane vesicles macrophages, are meticulously examined review. These methodologies designed enhance therapeutic efficacy against tumours, particularly those that drug-resistant metastatic. Collectively, these immunotherapies poised supplement refine current paradigms, thus heralding new frontier fight malignant

Language: Английский

Citations

22
Interactions between Nanoparticles and Intestine DOI Open Access
Manuela Vitulo, Elisa Gnodi, Raffaella Meneveri

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(8), P. 4339 - 4339

Published: April 14, 2022

The use of nanoparticles (NPs) has surely grown in recent years due to their versatility, with a spectrum applications that range from nanomedicine the food industry. Recent research focuses on development NPs for oral administration route rather than intravenous one, placing interactions between and intestine at centre attention. This allows functionalization exploit different characteristics digestive tract, such as pH, intestinal mucus layer, or absorption capacity. On other hand, these same can represent problem complexity, also considering potential matrix microbiota. review intends give comprehensive look into three main branches delivery through route: drug carriers systemic targets, case insulin an example; drugs locally active intestine, treatment inflammatory bowel diseases colon cancer; finally, concerns side effects accidental uncontrolled exposure employed additives, focus E171 (titanium dioxide) E174 (silver NPs).

Language: Английский

Citations

62
Gout therapeutics and drug delivery DOI

Xiuju Peng,

Xiaotong Li, Bing Xie

et al.

Journal of Controlled Release, Journal Year: 2023, Volume and Issue: 362, P. 728 - 754

Published: Sept. 21, 2023

Language: Английский

Citations

28
Advanced Nanomedicine: Redefining Therapeutic Paradigms for Inflammatory Bowel Disease DOI
Yinfeng Zhang, Tingting Wang, Meng Sun

et al.

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(19)

Published: March 16, 2023

Abstract Inflammatory bowel disease (IBD), a chronic and recurrent gastrointestinal inflammatory disorder with variety of painful clinical manifestations an increased risk cancerization or death, has become emerging challenge to global healthcare due its rapidly increasing incidence. At present, there is no efficient cure against IBD because the elusive etiology pathogenesis IBD. Therefore, development alternative therapeutic strategies positive efficacy reduced side effects urgently needed. In recent years, great prosperity nanomedicine promoted by advanced nanomaterials redefining more attractive promising for owing their advantages in physiological stability, bioavailability, targeting sites. this review, firstly basic characteristics healthy intestinal microenvironments are presented. Then, different administration routes nanotherapeutics treatment reviewed. Subsequently, specific focus placed on introduction nanotherapeutic treatments based pathogenesis. Finally, some future challenges perspectives currently developed nanomedicines provided. It believed that above topics will attract researchers from various fields including medicine, biological sciences, materials, chemistry pharmaceutics.

Language: Английский

Citations

26
Nanoprobiotics for Remolding the Pro-inflammatory Microenvironment and Microbiome in the Treatment of Colitis DOI
Jiwei Li, Mengchi Sun, Linlin Liu

et al.

Nano Letters, Journal Year: 2023, Volume and Issue: 23(18), P. 8593 - 8601

Published: Aug. 25, 2023

Despite the great progress of current bacterially based biotherapeutics, their unsatisfying efficacy and underlying safety problems have limited clinical application. Herein, inspired by probiotic Escherichia coli strain Nissle 1917, probiotic-derived outer membrane vesicles (OMVs) are found to serve as an effective therapeutic platform for treatment inflammatory bowel disease (IBD). To further enhance effect, OMV-encapsulating manganese dioxide nanozymes constructed, named nanoprobiotics, which can adhere inflamed colonic epithelium eliminate intestinal excess reactive oxygen species in murine IBD model. Moreover, combined with anti-inflammatory medicine metformin, nanoprobiotics could remold pro-inflammatory microenvironment, improve overall richness diversity gut microbiota, exhibit better than commercial chemotherapeutics. Importantly, insignificant overt systemic toxicity this was observed. By integrating cytokine storm calm biotherapy, we develop a safe bionanoplatform inflammation-mediated diseases.

Language: Английский

Citations

26
Anti-inflammatory peptide therapeutics and the role of sulphur containing amino acids (cysteine and methionine) in inflammation suppression: A review DOI

Catherin Ann Biji,

Akshad Balde, Rasool Abdul Nazeer

et al.

Inflammation Research, Journal Year: 2024, Volume and Issue: 73(7), P. 1203 - 1221

Published: May 21, 2024

Language: Английский

Citations

14
Biomaterials for inflammatory bowel disease: treatment, diagnosis and organoids DOI
Jia Wang, Yuying Shi,

Bei Mao

et al.

Applied Materials Today, Journal Year: 2024, Volume and Issue: 36, P. 102078 - 102078

Published: Jan. 20, 2024

Language: Английский

Citations

9
CO‐Releasing Polyoxometalates Nanozyme with Gut Mucosal Immunity and Microbiota Homeostasis Remodeling Effects for Restoring Intestinal Barrier Integrity DOI Creative Commons
Hongyang Lu, Qiang Zhou, Jiayu Li

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 13, 2025

Abstract Disruption of the intestinal epithelial barrier, driven by imbalances in gut mucosal immunity and microbial homeostasis, is central to onset progression inflammatory bowel disease (IBD). This study introduces a CO‐releasing polyoxometalates (POMs) nanozyme (PMC), synthesized coordinating pentacarbonyl manganese bromide with molybdenum‐based POM nanoclusters. PMC demonstrates targeted accumulation at IBD‐affected sites, efficient scavenging reactive oxygen species (ROS), responsive CO release, resulting multiple therapeutic effects. Extensive vitro vivo studies have validated exceptional capacity repair attributed their potent antioxidant anti‐inflammatory properties, thereby achieving significant efficacy ulcerative colitis treatment. 16S rRNA sequencing indicated that efficiently remodeled microbiota composition. Single‐cell RNA indicates reduction pro‐inflammatory M1 macrophages, alongside suppressed ROS signaling pathways. Concurrently, an increase reparative M2 macrophages stem cells observed, addition activation VEGF pathway NOTCH cells, underscoring potential restore immune balance promote tissue repair. positions as promising, multifunctional agent for IBD treatment owing its robust barrier‐restoring capability.

Language: Английский

Citations

1
Ligand-modified nanocarriers for oral drug delivery: Challenges, rational design, and applications DOI
Yaqi Zhang, Yaying Wang, Xiang Li

et al.

Journal of Controlled Release, Journal Year: 2022, Volume and Issue: 352, P. 813 - 832

Published: Nov. 11, 2022

Language: Английский

Citations

36