Research progress of extracellular vesicles and exosomes derived from mesenchymal stem cells in the treatment of oxidative stress-related diseases

Frontiers in Immunology, Journal Year: 2023, Volume and Issue: 14

Published: Aug. 14, 2023

There is growing evidence that mesenchymal stem cell-derived extracellular vesicles and exosomes can significantly improve the curative effect of oxidative stress-related diseases. Mesenchymal cell (MSC-EVs MSC-Exos) are rich in bioactive molecules have many biological regulatory functions. In this review, we describe how MSC-EVs MSC-Exos reduce related markers stress inflammation various systemic diseases, molecular mechanism treating apoptosis vascular injury induced by stress. The results a large number experimental studies shown both local administration effectively inhibit response diseases promote survival regeneration damaged parenchymal cells. mRNA miRNAs most important disease treatment, which apoptosis, necrosis lung, heart, kidney, liver, bone, skin other cells, their survive regenerate.

Language: Английский

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Targeting neutrophils: Mechanism and advances in cancer therapy

Clinical and Translational Medicine, Journal Year: 2024, Volume and Issue: 14(3)

Published: March 1, 2024

Abstract Background Cancer is a thorny problem which cannot be conquered by mankind at present and recent researchers have put their focus on tumor microenviroment. Neutrophils, the prominent leukocytes in peripheral blood that accumulate tumours, serves as frontline cells response to tumour progression owing rapid development of micro biotechnology. Hence, targeted therapy with these neutrophils has made targeting treatment promising field cancer therapy. Main body We broadly summarise some studies phenotypes functions tumour‐associated well unique web‐like products play role progression—neutrophil extracellular traps—and interactions between microenvironment. Moreover, several therapeutic progress provided potential strategies for cancer. Conclusion This review aims offer holistic perspective interventions further inspire more researches therapies.

Language: Английский

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Fe-Capsaicin Nanozymes Attenuate Sepsis-Induced Acute Lung Injury via NF-κB Signaling

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 73 - 90

Published: Jan. 1, 2024

Background: In sepsis, the lungs are one of most severely affected organs, usually resulting in acute lung injury (ALI). Capsaicin (CAP) is a natural compound found chili peppers that has pain-relieving and anti-inflammatory properties. Here, we report nanoparticles containing capsaicin iron (Fe-CAP NPs) exhibited effects treatment ALI. Methods: The morphological characteristics nanozymes were detected. RAW 264.7 cells divided into four groups: control, lipopolysaccharide (LPS), CAP+LPS Fe-CAP+LPS groups. expression inducible nitric oxide synthase (iNOS), transforming growth factor-β (TGF-β), tumor necrosis factor-α (TNF-α) was assessed by immunofluorescence, Western blot, enzyme-linked immunosorbent assay (ELISA). Nuclear factor kappa-B (NF-κB) determined blot. C57 mice LPS, Interleukin-6 (IL-6) iNOS detected Blot. IL-6 TNF-α serum ELISA. Extravasated Evans blue, histopathological evaluation wet-to-dry (W/D) weight ratio used to assess pulmonary capillary permeability. blood major organs (heart, liver, spleen, kidney) tested for toxicity Fe-CAP NPs. Results: LPS group, TNF-α, iNOS, p-NF-κB p-IKBα increased. However, their significantly decreased group. TGF-β showed opposite trend. vivo, notably increased group but with pretreatment. ameliorated EB leakage, improved histopathology tissue reduced W/D ratio. non-cytotoxicity, when studying these biological activities. Conclusion: NPs could alleviated inflammation inhibiting pro-inflammatory factors macrophages, increasing factors, alleviating damage. Keywords: capsaicin, macrophage, nanoparticles,

Language: Английский

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Nebulized Inhalation of Peptide-Modified DNA Origami To Alleviate Acute Lung Injury

Nano Letters, Journal Year: 2024, Volume and Issue: 24(20), P. 6102 - 6111

Published: May 13, 2024

Acute lung injury (ALI) is a severe inflammatory disease, with high mortality rates. Early intervention by reactive oxygen species (ROS) scavengers could reduce ROS accumulation, break the inflammation expansion chain in alveolar macrophages (AMs), and avoid irreversible damage to epithelial endothelial cells. Here, we reported cell-penetrating R9 peptide-modified triangular DNA origami nanostructures (tDONs-R9) as novel nebulizable drug that reach deep regions exhibit an enhanced uptake preference of macrophages. tDONs-R9 suppressed expression pro-inflammatory cytokines drove polarization toward anti-inflammatory M2 phenotype In LPS-induced ALI mouse model, treatment nebulized alleviated overwhelming ROS, cytokines, neutrophil infiltration lungs. Our study demonstrates has potential for treatment, programmable provide new delivery platform pulmonary disease efficiency biosecurity.

Language: Английский

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A new direction in periodontitis treatment: biomaterial-mediated macrophage immunotherapy

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 21, 2024

Abstract Periodontitis is a chronic inflammation caused by bacterial infection and intimately associated with an overactive immune response. Biomaterials are being utilized more frequently in periodontal therapy due to their designability unique drug delivery system. However, local systemic response reactions driven the implantation of biomaterials could result inflammation, tissue damage, fibrosis, which end up failure implantation. Therefore, immunological adjustment through precise design can reduce host reaction while eliminating tissue's long-term It important note that macrophages active system component participate progression disease intricate polarization mechanisms. And modulating macrophage designing has emerged as new technique. In this review, we discuss role periodontitis typical strategies for polarizing biomaterials. Subsequently, challenges potential opportunities using manipulate facilitate regeneration. Graphical

Language: Английский

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Engineered Biomimetic Nanovesicles Based on Neutrophils for Hierarchical Targeting Therapy of Acute Respiratory Distress Syndrome

ACS Nano, Journal Year: 2024, Volume and Issue: 18(2), P. 1658 - 1677

Published: Jan. 3, 2024

Acute Respiratory Distress Syndrome (ARDS) is a clinically severe respiratory disease that causes medical and economic burden. To improve therapeutic efficacy, effectively targeting delivery to the inflamed lungs cells remains an ongoing challenge. Herein, we designed engineered biomimetic nanovesicles (DHA@ANeu-DDAB) by fusion of lung-targeting functional lipid, neutrophil membrane containing activated β2 integrins, docosahexaenoic acid (DHA). By advantage lung lipid integrin adhesion, DHA@ANeu-DDAB can first target tissue further inflammatory vascular endothelial cells, achieve "tissue first, cell second" hierarchical delivery. In addition, integrins in could bind intercellular adhesion molecule-1/2 (ICAM-1/2) ligand on endothelium blood vessels, thus inhibiting neutrophils' infiltration circulation. DHA administration regulate macrophage phenotype promote its anti-inflammatory activity via enhanced biosynthesis specialized pro-resolving mediators. lipopolysaccharide-induced ARDS mouse model, afforded comprehensive efficient inhibition inflammation promoted acute damage repair. Through mimicking physiological processes, these vesicles as system possess good potential therapy for ARDS.

Language: Английский

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Musculoskeletal Organs‐on‐Chips: An Emerging Platform for Studying the Nanotechnology–Biology Interface

Advanced Materials, Journal Year: 2024, Volume and Issue: unknown

Published: March 16, 2024

Nanotechnology-based approaches are promising for the treatment of musculoskeletal (MSK) disorders, which present significant clinical burdens and challenges, but their translation requires a deep understanding complex interplay between nanotechnology MSK biology. Organ-on-a-chip (OoC) systems have emerged as an innovative versatile microphysiological platform to replicate dynamics tissue microenvironment studying nanotechnology-biology interactions. This review first covers recent advances applications OoCs ability mimic biophysical biochemical stimuli encountered by tissues. Next, integrating into OoCs, cellular responses behaviors may be investigated precisely controlling manipulating nanoscale environment. Analysis disease mechanisms, particularly bone, joint, muscle degeneration, drug screening development personalized medicine greatly facilitated using OoCs. Finally, future challenges directions outlined field, including advanced sensing technologies, integration immune-active components, enhancement biomimetic functionality. By highlighting emerging this aims advance intricate nanotechnology-MSK biology interface its significance in management, therapeutic interventional strategies.

Language: Английский

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Autophagy-modulating biomaterials: multifunctional weapons to promote tissue regeneration

Cell Communication and Signaling, Journal Year: 2024, Volume and Issue: 22(1)

Published: Feb. 15, 2024

Autophagy is a self-renewal mechanism that maintains homeostasis and can promote tissue regeneration by regulating inflammation, reducing oxidative stress promoting cell differentiation. The interaction between biomaterials cells significantly affects biomaterial-tissue integration regeneration. In recent years, it has been found affect various processes related to autophagy. utilization of in controlled environment become prominent approach for enhancing the capabilities. This involves regulation autophagy diverse types implicated regeneration, encompassing modulation inflammatory responses, stress, differentiation, proliferation, migration, apoptosis, extracellular matrix formation. addition, possess potential serve as carriers drug delivery, enabling either activating or inhibiting its processes. review summarizes relationship discusses role biomaterial-based advanced technologies used design autophagy-modulating are summarized, rational providing via modification chemistry surface incorporation molecules discussed. A better understanding well underlying molecular mechanisms, may lead new possibilities Video Abstract.

Language: Английский

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Nanocarriers for targeted drug delivery in the vascular system: focus on endothelium

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 12, 2024

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics, and modulating inflammatory responses. Nanocarriers hold transformative potential for precise drug delivery within the system, particularly targeting ECs therapeutic purposes. However, complex interactions between nanocarriers present significant challenges development clinical translation of nanotherapeutics. This review assesses recent advancements key strategies employing to ECs. It suggested that through physicochemical design surface modifications, can enhance specificity improve internalization efficiency Additionally, we elaborated on applications specifically designed treatment cardiovascular diseases, cancer metastasis, disorders. Despite these advancements, safety concerns, complexity vivo processes, challenge achieving subcellular remain obstacles effective with nanocarriers. A comprehensive understanding endothelial cell biology its interaction is crucial realizing full targeted systems.

Language: Английский

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Regulated programmed cell death in sepsis associated acute lung injury: From pathogenesis to therapy

International Immunopharmacology, Journal Year: 2025, Volume and Issue: 148, P. 114111 - 114111

Published: Jan. 19, 2025

Language: Английский

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