Advanced Healthcare Materials,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 26, 2024
During
acute
respiratory
distress
syndrome
(ARDS),
delayed
apoptosis
of
neutrophils
and
impaired
efferocytosis
macrophages
constitute
two
critical
limiting
steps,
leading
to
secondary
inflammatory
storm
posing
a
significant
threat
human
health.
However,
due
the
failure
previous
single
target-centric
treatments
effectively
address
these
steps
in
controlling
storm,
no
available
therapies
are
approved
for
ARDS
treatment.
Herein,
inspired
by
spontaneous
inflammation
resolution,
kinds
Apoptosis
Efferocytosis
Restored
Nanoparticles
(AER
NPs)
proposed
overcome
counteracting
severe
storm.
For
first
step,
neutrophil-targeted
apoptosis-restored
nanoparticles
(AR
accelerated
programmed
neutrophils.
The
resolution
step
facilitated
accumulation
macrophage-targeted
efferocytosis-restored
(ER
NPs),
thereby
restoring
macrophage
alleviating
second
step.
results
indicated
that
after
sequential
treatment
with
AER
NPs,
recruited
decreased
13.86%,
increased
563.24%.
NPs
promoted
established
self-healing
virtuous
loop
addressing
ultimately
treating
ARDS.
This
work
suggests
strategy
holds
promise
as
potential
approach
advancing
therapy.
Burns & Trauma,
Journal Year:
2024,
Volume and Issue:
12
Published: Jan. 1, 2024
Abstract
Extracellular
vesicles
(EVs)
are
heterogeneous
membrane-like
secreted
by
living
cells
that
involved
in
many
physiological
and
pathological
processes
act
as
intermediaries
of
intercellular
communication
molecular
transfer.
Recent
studies
have
shown
EVs
from
specific
sources
regulate
tissue
repair
regeneration
delivering
proteins,
lipids,
nucleic
acids
to
target
signaling
molecules.
Nanotechnology
breakthroughs
facilitated
the
development
exploration
engineered
for
repair.
Enhancements
through
gene
editing,
surface
modification,
content
modification
further
improved
their
therapeutic
efficacy.
This
review
summarizes
potential
regeneration,
mechanisms
action,
research
progress
regenerative
medicine.
highlights
design
logic
typical
examples
explores
prospects
The
aim
this
is
provide
new
insights
into
applications,
thereby
expanding
use
Small,
Journal Year:
2024,
Volume and Issue:
20(33)
Published: April 5, 2024
Ulcerative
colitis
(UC),
an
immune-mediated
chronic
inflammatory
disease,
drastically
impacts
patients'
quality
of
life
and
increases
their
risk
colorectal
cancer
worldwide.
However,
effective
oral
targeted
delivery
retention
drugs
in
colonic
lesions
are
still
great
challenges
the
treatment
UC.
Coacervate
microdroplets,
formed
by
liquid-liquid
phase
separation,
recently
explored
drug
as
simplicity
fabrication,
spontaneous
enrichment
on
small
molecules
biological
macromolecules,
high
loading
capacity.
Herein,
this
study,
a
biocompatible
diethylaminoethyl-dextran
hydrochloride/sodium
polyphenylene
sulfonate
coacervates,
coated
with
eudragit
S100
to
improve
stability
colon
targeting
ability,
named
EU-Coac,
is
developed.
Emodin,
active
ingredient
traditional
Chinese
herbs
proven
alleviate
UC
symptoms,
loaded
EU-Coac
(EMO@EU-Coac)
showing
good
gastric
acid
pepsin
pH-responsive
release
behavior.
After
administration,
EMO@EU-Coac
can
effectively
target
retain
colon,
displaying
therapeutic
effects
through
attenuating
inflammation
oxidative
stress
response,
repairing
epithelia,
well
regulating
intestinal
flora
balance.
In
short,
study
provides
novel
facile
coacervate
microdroplet
system
for
treatment.
Journal of Nanobiotechnology,
Journal Year:
2025,
Volume and Issue:
23(1)
Published: Feb. 6, 2025
Neutrophil
extracellular
traps
(NETs)
participate
in
both
host
defense
and
the
pathogenesis
of
various
diseases,
such
as
infections,
thrombosis,
tumors.
While
they
help
capture
eliminate
pathogens,
NETs'
excessive
or
dysregulated
formation
can
lead
to
tissue
damage
disease
progression.
Therapeutic
strategies
targeting
NET
modulation
have
shown
potential,
but
challenges
remain,
particularly
achieving
precise
drug
delivery
maintaining
stability.
Nanoparticle
(NP)-based
systems
offer
innovative
solutions
for
overcoming
limitations
conventional
therapies.
This
review
explores
biological
mechanisms
formation,
their
interactions
with
NPs,
therapeutic
applications
NP-based
modulating
NETs.
We
discuss
how
NPs
be
designed
either
promote
inhibit
provide
a
comprehensive
analysis
potential
treating
NET-related
diseases.
Additionally,
we
address
current
future
prospects
therapies
research,
aiming
bridge
gap
between
nanotechnology
development
novel
approaches.
Nano Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 3, 2025
Rheumatoid
arthritis
(RA)
is
a
chronic
autoimmune
disease
distinguished
by
inflammatory
synovitis.
Chrysin
can
alleviate
the
response
and
inhibit
progression
of
RA.
However,
unfavorable
physicochemical
properties
nonselective
biodistribution
chrysin
make
it
difficult
to
achieve
good
therapeutic
efficacy.
To
address
these
challenges,
we
developed
biomimetic
nanocarrier
enhance
targeted
delivery
synoviocytes,
key
cellular
component
in
RA
pathology.
Our
nanodrug,
FMPlipo@C,
was
engineered
integrating
fibroblast-like
synoviocyte
(FLS)
membrane
proteins
into
chrysin-loaded
liposomes.
This
innovative
approach
harnesses
homologous
targeting
mediated
FLS
direct
liposomes
inflamed
joints,
facilitating
cargo
release
within
synoviocytes.
We
showed
that
FMPlipo@C
reduces
inflammation
collagen-induced
rheumatoid
(CIA)
model
mice
inhibiting
HIF-1α/iNOS/NLRP3
pathway,
protecting
cartilage,
preventing
bone
erosion,
thus
reducing
swelling
stiffness.
study
offers
valuable
insights
development
novel
strategies
for
treatment
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 5, 2025
Abstract
Accurate
and
early
detection
of
pneumonia
is
crucial
for
effective
treatment;
however,
current
diagnostic
methods
often
lack
the
necessary
specificity
sensitivity,
particularly
in
stages.
Herein,
we
begin
with
a
comprehensive
bioinformatics
analysis,
identifying
neutrophils
as
key
effectors
pathogenesis,
neutrophil
elastase
(NE)
critical
biomarker
associated
progression.
We
subsequently
develop
NE-responsive
probe
(NERP),
composed
hemicyanine
fluorophore
linked
to
an
NE-sensitive
peptide,
specifically
designed
activation
inflamed
tissues.
To
facilitate
urinalysis,
NERP
further
refined
into
active
targeting
responsive
probes
(ATRPH).
ATRPH
demonstrate
exceptional
sensitivity
both
vivo
imaging
urine-based
detection,
urine
analysis
offering
non-invasive,
early-stage
option
that
overcomes
limitations
tissue
penetration
low
accuracy
traditional
modalities.
Additionally,
highly
drug
screening,
dosage
optimization,
exploring
mechanisms
NE
production,
which
offers
valuable
insights
therapeutic
efficacy.
Moreover,
can
also
be
prepared
liposomes
(ATRPL)
membrane
doped
(ATRPM)
nanoparticles
through
formulation
used
systemic
inflammation
intravenous
administration.
This
screening
design
strategy
not
only
enhances
diagnosis
treatment
via
different
routes
administration,
but
has
broader
potential
other
inflammatory
lung
diseases,
marking
significant
advancement
precision
medicine.
Advanced Functional Materials,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 28, 2025
Abstract
Due
to
the
resistance
immunotherapies
is
prevalent,
exploring
universal
immune
activation
strategies
are
necessary.
Pathogenic
systems
can
inherently
stimulate
innate
immunity
and
may
potentially
boost
anti‐tumor
response;
however,
their
safety
profile
not
optimal.
In
this
study,
a
pathogen‐mimicking
cancer
vaccine
(DFC‐YM)
based
on
engineered
tumor
cells
introduced
potentiate
in
colon
treatment.
By
activating
viral‐related
genes
within
inducing
transcription
of
endogenous
double‐stranded
RNA,
DFC‐YM
endowed
with
virus‐like
genome
inside.
With
externally
modification
nano‐sized
yeast
membrane
particles
(YM),
simulate
surface
structure
characteristics
microorganisms.
Upon
administration,
exhibits
pathogen‐like
characteristics,
capable
recruiting
substantial
number
cells,
particularly
neutrophils,
dendritic
macrophages,
thereby
impeding
progression
cancer.
When
further
combined
prostaglandin
E2
inhibitor,
increase
CD8
+
T
lymphocyte
populations,
demonstrating
an
enhanced
therapeutic
efficacy.
This
innovative
strategy
presents
new
concept
for
development
broad‐spectrum
immunotherapeutic
approaches
against
