Engineering,
Journal Year:
2024,
Volume and Issue:
40, P. 61 - 69
Published: April 23, 2024
Lianhua
Qingke
tablets,
a
patented
traditional
Chinese
medicine
that
has
validated
clinical
efficacy
for
treating
cough
caused
by
severe
acute
respiratory
syndrome
coronavirus
2
infection,
lack
rigorous
evidence-based
research
evaluating
their
effect
on
long
disease
(COVID)
cough.
A
randomized,
double-blind,
placebo-controlled,
multicenter
study
was
conducted
among
patients
with
COVID
from
19
hospitals
and
23
community
health
centers
in
China.
Patients
were
randomized
1:1
to
receive
either
tablets
or
placebo
orally
14
days
(4
1.84
g,
3
times
day).
The
primary
endpoint
indicator
the
disappearance
of
cough,
remission
also
considered.
Among
482
patients,
480
(full
analysis
set
480;
per-protocol
470;
safety
480)
included
analysis.
According
full
analysis,
time
until
significantly
shorter
trial
group
than
control
group,
significant
increase
14-day
rate.
Accordingly,
group.
change
total
symptom
score
greater
day
7
14,
consistent
results
indicated
visual
analog
scale
(VAS)
evaluation
test
(CET)
scores.
No
serious
adverse
events
recorded
during
study.
improved
symptoms
Acta Pharmaceutica Sinica B,
Journal Year:
2024,
Volume and Issue:
14(5), P. 2298 - 2316
Published: Jan. 26, 2024
Bacterial
infection
hampers
wound
repair
by
impeding
the
healing
process.
Concurrently,
inflammation
at
site
triggers
production
of
reactive
oxygen
species
(ROS),
causing
oxidative
stress
and
damage
to
proteins
cells.
This
can
lead
chronic
wounds,
posing
severe
risks.
Therefore,
eliminating
bacterial
reducing
ROS
levels
are
crucial
for
effective
healing.
Nanozymes,
possessing
enzyme-like
catalytic
activity,
convert
endogenous
substances
into
highly
toxic
substances,
such
as
ROS,
combat
bacteria
biofilms
without
inducing
drug
resistance.
However,
current
nanozyme
model
with
single
enzyme
activity
falls
short
meeting
complex
requirements
antimicrobial
therapy.
Thus,
developing
nanozymes
multiple
enzymatic
activities
is
essential.
Herein,
we
engineered
a
novel
metalloenzyme
called
Ru-procyanidin
nanoparticles
(Ru-PC
NPs)
diverse
aid
infections.
Under
acidic
conditions,
due
their
glutathione
(GSH)
depletion
peroxidase
(POD)-like
Ru-PC
NPs
combined
H2O2
exhibit
excellent
antibacterial
effects.
in
neutral
environment,
NPs,
catalase
(CAT)
decompose
O2,
alleviating
hypoxia
ensuring
sufficient
supply.
Furthermore,
possess
exceptional
antioxidant
capacity
through
superior
superoxide
dismutase
(SOD)
effectively
scavenging
excess
nitrogen
(RNS)
environment.
maintains
balance
system
prevents
inflammation.
also
promote
polarization
macrophages
from
M1
M2,
facilitating
More
importantly,
show
good
biosafety
negligible
toxicity.
In
vivo
models
have
confirmed
efficacy
inhibiting
promoting
The
focus
this
work
highlights
quadruple
its
potential
reduce
bacteria-infected
World Journal of Gastroenterology,
Journal Year:
2025,
Volume and Issue:
31(6)
Published: Jan. 10, 2025
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
enters
host
cells
via
the
angiotensin-converting
enzyme
(ACE2)
receptor.
Mounting
evidence
has
indicated
presence
of
hepatic
SARS-CoV-2
infection
and
liver
injury
in
patients
with
disease
2019
(COVID-19).
Understanding
mechanisms
is
crucial
for
addressing
COVID-19-related
pathology
developing
targeted
therapies.
This
editorial
discusses
significance
ACE2
infection,
drawing
on
research
by
Jacobs
et
al.
Their
findings
indicate
that
expression,
frequency
severity
are
elevated
pre-existing
chronic
diseases.
These
data
suggest
could
be
a
promising
therapeutic
target
COVID-19.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 24, 2025
Uncommon
diterpenoids
with
diverse
frameworks,
including
one
unexpected
iodinated
oxa-6/6/6/6-tetracyclic
diterpene
(1)
and
its
monobrominated
6/6/6-tricyclic
analogue
(2)
novel
isodolastane-type
featuring
an
unusual
aromatic
5/7/6-tricyclic
ring
system
(3)
as
well
a
related
known
dolastane-type
diterpenoid
(4),
were
isolated
from
the
South
China
Sea
sponge
Spongia
officinalis.
Their
structures,
absolute
configurations,
established
by
extensive
spectroscopic
data
analysis,
X-ray
diffraction
quantum
mechanical-nuclear
magnetic
resonance
time-dependent
density
functional
theory/electronic
circular
dichroism
calculations.
A
plausible
biosynthetic
pathway
of
new
compounds
1–3
was
proposed.
In
bioassays,
2
4
found
to
exhibit
significant
anti-inflammatory
effects
on
lipopolysaccharide-induced
inflammation
in
BV-2
microglial
cells.
Frontiers in Immunology,
Journal Year:
2025,
Volume and Issue:
16
Published: April 2, 2025
Macrophages
are
increasingly
recognized
as
crucial
therapeutic
targets
in
the
treatment
of
diverse
pathological
conditions.
While
considerable
research
has
focused
on
macrophage-related
mechanisms
within
Traditional
Chinese
Medicine
(TCM),
there
remains
a
notable
absence
comprehensive
quantitative
analyses
this
field.
This
study
aims
to
examine
evolutionary
trajectory
TCM
from
2003
2023,
providing
insights
guide
future
investigative
directions.
We
searched
for
articles
published
between
and
2023
Web
Science
Core
Collection
(WoSCC)
database
analyzed
them
using
R
software,
VOSviewer
CiteSpace.
A
total
1,823
documents
were
obtained
through
search.
The
results
indicated
that
number
publications
exhibited
an
upward
trend,
with
majority
these
originating
academic
institutions
authored
by
scholars.
observation
suggests
potential
correlation
growing
prominence
medicine
China.
Macrophage
polarizations,
prominent
focus
macrophages,
also
assumed
significant
role
domain
macrophages
TCM-related
disciplines.
publication
targeting
some
diseases
is
very
promising,
especially
ulcerative
colitis,
tumor-related
diseases,
liver
diseases.
provides
more
analysis
current
status
areas
field
macrophage
TCM,
offering
valuable
prospective
endeavors.
Macrophage-related
studies
have
garnered
increasing
attention
global
scholars
researchers
worldwide,
expected
become
hotspot
develop
new
drugs
treat
future.
comprehensively
analyzes
hotspots
medicine,
which
can
provide
references
research.
