Cold and hot tumors: from molecular mechanisms to targeted therapy

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Oct. 18, 2024

Immunotherapy has made significant strides in cancer treatment, particularly through immune checkpoint blockade (ICB), which shown notable clinical benefits across various tumor types. Despite the transformative impact of ICB treatment therapy, only a minority patients exhibit positive response to it. In with solid tumors, those who respond well typically demonstrate an active profile referred as "hot" (immune-inflamed) phenotype. On other hand, non-responsive may distinct "cold" (immune-desert) phenotype, differing from features tumors. Additionally, there is more nuanced "excluded" positioned between and categories, known type. Effective differentiation understanding intrinsic factors, characteristics, TME, external factors are critical for predicting results. It widely accepted that therapy exerts profound effect on limited efficacy against or "altered" necessitating combinations therapeutic modalities enhance cell infiltration into tissue convert tumors ones. Therefore, aligning traits this review systematically delineates respective influencing extensively discusses varied approaches drug targets based assess efficacy.

Language: Английский

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Complications and comorbidities associated with antineoplastic chemotherapy: Rethinking drug design and delivery for anticancer therapy

Acta Pharmaceutica Sinica B, Journal Year: 2024, Volume and Issue: 14(7), P. 2901 - 2926

Published: March 11, 2024

Despite the considerable advancements in chemotherapy as a cornerstone modality cancer treatment, prevalence of complications and pre-existing diseases is on rise among patients along with prolonged survival aging population. The relationships between these disorders are intricate, bearing significant influence quality life individuals presenting challenges for prognosis outcomes malignancies. Herein, we review prevailing comorbidities that often accompany summarize lessons to learn from inadequate research management this scenario, an emphasis possible strategies reducing potential alleviating comorbidities, well overview current preclinical models practical advice establishing bio-faithful such complex context.

Language: Английский

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Insights of probiotics as an alternative medicine for cancer therapy, mechanism, and applications

Medicine in Microecology, Journal Year: 2024, Volume and Issue: 22, P. 100111 - 100111

Published: Aug. 25, 2024

Probiotics are microbes associated with a wide range of health benefits and modulate gut flora by releasing effector molecules. The efficacy probiotics at various stages cancer treatment has been well demonstrated. can increase the potency cancer-based immunotherapy, which be administered before, during, or post-phase therapy. consumption among patients minimize detrimental effects chemotherapy act as potential tool for Genetically engineered express specific antigens that combat deadly pathogens. These essential features utilized in other applications. This review aims to provide updated information on mechanism action their applications Moreover, few significant like; antioxidative therapy, biotechnology-based improvement, developing potent probiotic strains effective also discussed.

Language: Английский

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Recent progress on drug delivery systems of regulating intratumoral bacteria for tumor therapy

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110907 - 110907

Published: Feb. 1, 2025

Language: Английский

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Intratumoral microbiome: implications for immune modulation and innovative therapeutic strategies in cancer

Journal of Biomedical Science, Journal Year: 2025, Volume and Issue: 32(1)

Published: Feb. 19, 2025

Abstract Recent advancements have revealed the presence of a microbiome within tumor tissues, underscoring crucial role in ecosystem. This review delves into characteristics intratumoral microbiome, its dual modulating immune responses and potential to both suppress promote growth. We examine state-of-the-art techniques for detecting analyzing bacteria, with particular focus on their interactions system resulting implications cancer prognosis treatment. By elucidating intricate crosstalk between host system, we aim uncover novel therapeutic strategies that enhance efficacy treatments. Additionally, this addresses existing challenges future prospects burgeoning field, advocating integration research comprehensive therapy frameworks. Graphical

Language: Английский

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Gut microbiota and gastrointestinal tumors: insights from a bibliometric analysis

Frontiers in Microbiology, Journal Year: 2025, Volume and Issue: 16

Published: April 8, 2025

Despite the growing number of studies on role gut microbiota in treating gastrointestinal tumors, overall research trends this field remain inadequately characterized. A bibliometric analysis was conducted using publications retrieved from Web Science Core Collection (up to September 30, 2024). Analytical tools including VOSviewer, CiteSpace, and an online platform were employed evaluate hotspots. Analysis 1,421 revealed significant geographical disparities output, with China United States leading contributions. Institutionally, University Adelaide, Zhejiang University, Shanghai Jiao Tong prominent contributors. Authorship identified Hannah R. Wardill as most prolific author, while International Journal Molecular Sciences emerged a journal. Rapidly frontiers include "proliferation," "inhibition," "immunotherapy," "drug delivery," "tumorigenesis." This study provides comprehensive overview highlights emerging directions, aiming advance scientific clinical applications tumor therapy.

Language: Английский

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The metabolic dialogue between intratumoural microbes and cancer: implications for immunotherapy

EBioMedicine, Journal Year: 2025, Volume and Issue: 115, P. 105708 - 105708

Published: April 22, 2025

Language: Английский

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Intratumoral Microbiota: Metabolic Influences and Biomarker Potential in Gastrointestinal Cancer

Biomolecules, Journal Year: 2024, Volume and Issue: 14(8), P. 917 - 917

Published: July 27, 2024

Gastrointestinal (GI) cancers impose a substantial global health burden, highlighting the necessity for deeper understanding of their intricate pathogenesis and treatment strategies. This review explores interplay between intratumoral microbiota, tumor metabolism, major types GI (including esophageal, gastric, liver, pancreatic, colorectal cancers), summarizing recent studies elucidating clinical implications future directions. Recent research revealed altered microbial signatures within tumors, impacting progression, immune responses, outcomes. Dysbiosis-induced alterations in including glycolysis, fatty acid amino play critical roles cancer progression therapeutic resistance. The integration molecular mechanisms potential biomarkers into this further enhances prognostic significance microbiota composition opportunities targeting microbiota-mediated metabolism. Despite advancements, challenges remain dynamic interactions microenvironment (TME). Future directions, advanced omics technologies prospective studies, offer promising avenues precision oncology personalized interventions cancer. Overall, integrating microbiota-based approaches management holds promise improving patient outcomes survival.

Language: Английский

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Microbiota in tumors: new factor influencing cancer development

Cancer Gene Therapy, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 28, 2024

Language: Английский

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Bacteria-Based Bioactive Materials for Tumor Immunotherapy

Precision medicine and engineering., Journal Year: 2024, Volume and Issue: unknown, P. 100013 - 100013

Published: Nov. 1, 2024

Language: Английский

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