Carrier-Free Nanoagent Interfering with Cancer-Associated Fibroblasts’ Metabolism to Promote Tumor Penetration for Boosted Chemotherapy DOI
Lili Yu, Xiaocheng Zhou, Zhi Liu

et al.

Nano Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 13, 2024

Elevated production of extracellular matrix (ECM) in tumor stroma is a critical obstacle for drug penetration. Here we demonstrate that ATP-citrate lyase (ACLY) significantly upregulated cancer-associated fibroblasts (CAFs) to produce ECM. Using self-assembling nanoparticle-design approach, carrier-free nanoagent (CFNA) fabricated by simply assembling NDI-091143, specific ACLY inhibitor, and doxorubicin (DOX) or paclitaxel (PTX), the first-line chemotherapeutic drug, via multiple noncovalent interactions. After arriving at CAFs-rich site, NDI-091143-mediated inhibition CAFs can block de novo synthesis fatty acid, thereby dampening acid-involved energy metabolic process. As lack enough energy, energetic will be dispirited state unable abundant ECM, improving perfusion tumors enhancing efficacy chemotherapy. Such simple strategy aimed CAFs' ACLY-mediated metabolism pathway presents feasibility stromal reduction potentiate

Language: Английский

Metformin-based nanomedicines for reprogramming tumor immune microenvironment DOI
Jieyu Liu, Xiaoling Li, Yinggang Li

et al.

Theranostics, Journal Year: 2024, Volume and Issue: 15(3), P. 993 - 1016

Published: Dec. 2, 2024

Immunotherapy has transformed current cancer management, and it achieved significant progress over last decades. However, an immunosuppressive tumor microenvironment (TME) diminishes the effectiveness of immunotherapy by suppressing activity immune cells facilitating immune-evasion. Adenosine monophosphate-activated protein kinase (AMPK), a key modulator cellular energy metabolism homeostasis, gained growing attention in anti-tumor immunity. Metformin is usually considered as cornerstone diabetes its role activating AMPK pathway also been extensively explored therapy although findings on remain inconsistent. nanomedicine formulation found to hold potential reprogramming TME through immunometabolic modulation both cells. This review elaborates foundation via metformin-based nanomedicines, offering valuable insights for next generation therapy.

Language: Английский

Citations

34
Nanomedicine in Immunotherapy for Non‐Small Cell Lung Cancer: Applications and Perspectives DOI Open Access
Shuangsi Liao, Xiaoling Li, You Lü

et al.

Small Methods, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Abstract Non‐small cell lung cancer (NSCLC) has a strikingly high incidence rate globally. Although immunotherapy brings great breakthrough in its clinical treatment of NSCLC, significant challenges still need to be overcome. The development novel multi‐functional nanomedicines the realm tumor offers promising opportunities for NSCLC patients, as exhibit advantages, including specific targeting cells, improved drug bioavailability, reduced systemic toxicity, and overcoming immune resistance. In this review, core features current status strategies checkpoint blockade, antibody–drug conjugates, engagers, adoptive vaccines, are surveyed. Particular emphasis is placed on recent that boost these strategies. Nanomedicine can provide perspectives immunotherapy.

Language: Английский

Citations

1
Stimuli-responsive polymer-dasatinib prodrug to reprogram cancer-associated fibroblasts for boosted immunotherapy DOI
Yuxin Zhang, Jie Zhou, Yiyan Wang

et al.

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: 381, P. 113606 - 113606

Published: March 5, 2025

Language: Английский

Citations

1
Tailoring the dendronized structures of cyclodextrin-based supramolecular nanoassemblies for enhanced tumor paraptosis via disrupting endoplasmic reticulum homeostasis DOI
Jiecheng Ji, Jie Zhou, Xue Li

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
Unraveling the breast cancer tumor microenvironment: crucial factors influencing natural killer cell function and therapeutic strategies DOI Creative Commons
Feifei Li, Chunfang Gao,

Yan Huang

et al.

International Journal of Biological Sciences, Journal Year: 2025, Volume and Issue: 21(6), P. 2606 - 2628

Published: March 24, 2025

Natural killer (NK) cells have emerged as a novel and effective treatment for breast cancer. Nevertheless, the cancer tumor microenvironment (TME) manifests multiple immunosuppressive mechanisms, impeding proper execution of NK cell functions. This review summarizes recent research on influence TME functionality in It delves into effects internal environment elucidates roles diverse stromal components, immune cells, signaling molecules regulating activity within TME. also therapeutic strategies based small-molecule inhibitors, antibody therapies, natural products, well progress preclinical clinical trials. By enhancing our understanding formulating to counteract its effects, we could fully harness promise treatment.

Language: Английский

Citations

0
Nano-Based Strategies Aiming at Tumor Microenvironment for Improved Cancer Therapy DOI
Tianhui Liu,

Changshun Lu,

Xue Jiang

et al.

Molecular Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Malignant tumors pose a considerable threat to human life and health. Traditional treatments, such as radiotherapy chemotherapy, often lack specificity, leading collateral damage normal tissues. Tumor microenvironment (TME) is characterized by hypoxia, acidity, redox imbalances, elevated ATP levels factors that collectively promote tumor growth metastasis. This review provides comprehensive overview of the nanoparticles developed in recent years for TME-responsive strategies or TME-modulating methods therapy. The focus on designing synthesizing can interact with achieve precisely controlled drug release. These activate release under specific conditions within environment, thereby enhancing efficacy drugs while reducing toxicity cells. Moreover, simply eliminating cells does not fundamentally solve problem. Only comprehensively regulating TME make it unsuitable cell survival proliferation we more thorough therapeutic effects reduce risk recurrence. regulation aim suppress metastasis modulating various components TME. only improve treatment outcomes but also have potential lay foundation future personalized cancer therapies.

Language: Английский

Citations

0
Anti‐Tumor Strategies Targeting Nutritional Deprivation: Challenges and Opportunities DOI Open Access
Jinsheng Shi, Wei Han, Jie Wang

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 2, 2025

Higher and richer nutrient requirements are typical features that distinguish tumor cells from AU: cells, ensuring adequate substrates energy sources for cell proliferation migration. Therefore, deprivation strategies based on targeted technologies can induce impaired viability in which more sensitive than normal cells. In this review, nutrients required by related metabolic pathways introduced, anti-tumor developed to target described. addition the nutritional characteristics of other microenvironment (including macrophages, neutrophils, natural killer T cancer-associated fibroblasts) new also summarized. conclusion, recent advances targeting blockade reviewed, challenges prospects these discussed, theoretical significance optimizing clinical application nutrition strategies.

Language: Английский

Citations

0
Topology‐Oriented Lymph Node Drainage of Dendritic Polymer‐TLR Agonist Conjugates to Enhance Vaccine Immunogenicity DOI Open Access
Long Ren, Bing Wang,

Di Miao

et al.

Advanced Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 17, 2025

Strategically targeting lymph nodes (LNs) to orchestrate the initiation and regulation of adaptive immune responses is one most pressing challenges in context vaccination. Herein, a series polymer-TLR agonist conjugates (PTACs) developed investigate impact dendritic-topological characteristics on their LN activity vivo, molecular weight (MW) pharmacokinetics support homing. Notably, dendritic 6-arm PTAC with MW 60 kDa (6A-PTAC-60k) rapidly delivered cargo draining LNs after administration peripheral tissues. Specifically, this topologic structure ameliorated behavior within lymphatic vessels LNs, including an elevated amount TLR7/8 improved distribution pattern among barrier cells cells, increased permeability, prolonged retention. Furthermore, 6A-PTAC-60k formulation induced broad antibody T cell responses, enhancing vaccine immunogenicity suppressing tumor growth. The results revealed that both topology polymers are crucial factors for immunoadjuvant functional which, turn, enhanced formulation. This study may provide chemical structural basis optimizing design delivery systems.

Language: Английский

Citations

0
CNPY3’s regulation of tumor microenvironment and its impact on colon cancer aggressiveness DOI Creative Commons
Xucan Gao, Biaohuan Zhou, Xiaohui Feng

et al.

Molecular Medicine, Journal Year: 2025, Volume and Issue: 31(1)

Published: March 7, 2025

Abstract Background Canopy FGF signaling regulator 3 (CNPY3) has been implicated in tumor progression. However, its specific role colon cancer (CC) remains unclear. This study aims to investigate the function of CNPY3 CC and potential as a therapeutic target. Methods A total 201 tissue specimens 67 adjacent non-cancerous tissues were collected for analysis. expression was assessed using immunohistochemistry quantitative real-time PCR. Functional assays conducted cell lines (HT-29 SW-620) following knockdown evaluate effects on proliferation, migration, apoptosis. Gene profiling, fibroblast co-culture experiments, vivo xenograft models also conducted. Results Increased correlated with advanced stages poorer prognosis. Knockdown significantly inhibited induced apoptosis lines. depletion modulated behavior, inhibiting their transformation into cancer-associated fibroblasts. Pathway analysis revealed that affected cycle p53 pathways, reduced activation MAPK PI3K/AKT pathways. Additionally, enhanced sensitivity 5-fluorouracil. In studies demonstrated resulted smaller sizes weights than controls. Conclusions is crucial progression, correlating aggressiveness poor patient outcomes. Targeting may offer promising strategy valuable prognostic marker management.

Language: Английский

Citations

0
Nanoengineering of Phosphate/Phosphonate Drugs via Competitive Replacement with Metal‐Phenolic Networks to Overcome Breast Tumor with Lung and Bone Metastasis DOI Creative Commons

Wanrui Shi,

Dashuai Liu,

Wenjie Feng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: 12(2)

Published: Nov. 18, 2024

Abstract Phosphate and phosphonate drugs are vital in building organisms, regulating physiological processes, exhibiting diverse biological activities, including antiviral, antibacterial, antineoplastic, enzyme‐inhibitory effects. However, their therapeutic potential is limited by the lack of advanced nanoengineering technologies. Herein, a competitive coordination strategy for phosphate/phosphonate introduced. By leveraging difference capabilities between polyphenols phosphates/phosphonates with metal ions, various phosphate/phosphonate‐based nanodrugs using metal‐phenolic networks (MPNs) as templates agents constructed. The dynamic nature these bonds imparts stimuli‐responsiveness to nanodrugs, allowing targeted release therapy. As proof concept, Fe 3+ galangin used form MPN template, zoledronic acid cGAMP agents, DOX loaded drug construct DOX@Fe‐galangin@Fe‐zoledronic acid‐cGAMP nanodrugs. results demonstrate that, triggering pyroptosis activating cGAS‐STING pathway, exhibit potent cytotoxicity accurate selectivity eradicating orthotopic breast tumors, activate an antitumor immune response against lung bone metastases. Because applicable variety it holds significant enhancing clinical efficacy advancing nanodrug development complex applications.

Language: Английский

Citations

1