Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids DOI
Ayushi Chaudhary, Ashwini Kumar, Nirmal Keshari Swain

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Triple‐negative breast cancer (TNBC) presents a formidable challenge due to its aggressive behavior and limited array of treatment options available. This study focuses on employing nanoaggregate material organometallic Ir(III) complexes for treating TNBC cell line MDA‐MB‐231. In this approach, with enhanced cellular permeability are strategically designed achieved through the incorporation COOMe groups into their structure. The lead compound, IrL 1 , exhibits promiscuous nanoscale aggregation in RPMI culture media, characterized by stable hydrodynamic effective diameter ranging from 190 202 nm over 48 h. With excellent photo‐responsive contrast‐enhanced imaging properties an outstanding IC 50, 48h value 36.05± 0.03 n m when irradiated 390 light MDA‐MB‐231 (IC h Cisplatin is 5.29 µ ). cell, investigation confirms that nanoaggregates internalization via energy‐dependent endocytosis undergo ferroptosis ROS mediated death cells. Further, these vivo studies using NOD‐SCID mice confirmed tendency ablate tumors inoculated models at therapeutically relevant doses. Thus, comprehensive approach holds promise expanding repertoire adaptable characteristics, thereby advancing clinical utility nanomedicine holistic metastatic 3D triple‐negative tumor spheroids.

Language: Английский

Recent progress in stimuli‐activable metallo‐prodrugs for cancer therapy DOI Creative Commons
Jinzhe Liang,

Fangmian Wei,

Hui Chao

et al.

Smart Molecules, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract The clinical approval of platinum‐based drugs has prompted the development novel metallo‐complexes during last several decades, while severe problems, especially for poor water solubility, drug resistance and toxicity in patients, greatly hindered trials curative efficacy. To address these issues, concept metallo‐prodrugs been proposed oncology. Some stimuli‐activable provide new insights designing preparing site‐specific prodrugs with maximized therapeutic efficacy negligible unfavorable by‐effects. In this review, recent progress past 20 years overviewed, where endogenous exogenous stimuli have involved. Typical examples smart are discussed regarding to their molecular structure, activation mechanism, promising biomedical applications. end, challenges future perspectives discussed.

Language: Английский

Citations

5
Metal-based immunogenic cell death inducers for cancer immunotherapy DOI Creative Commons
Jun Zou, Meng Rui Chang, Nikita A. Kuznetsov

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Immunogenic cell death (ICD) has attracted enormous attention over the past decade due to its unique characteristics in cancer and role activating innate adaptive immune responses against tumours. Many efforts have been dedicated screening, identifying discovering ICD inducers, resulting validation of several based on metal complexes. In this review, we provide a comprehensive summary current metal-based their molecular mechanisms for triggering initiation subsequent protective antitumour responses, along with considerations validating both vitro vivo. We also aim offer insights into future development complexes enhanced ICD-inducing properties applications potentiating immunity.

Language: Английский

Citations

0
Metallodrugs: From mere cytotoxic agents to immune modulators and checkpoint inhibitors DOI
Muhammad Nafees, Muhammad Hanif,

Piaoping Yang

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 111013 - 111013

Published: Feb. 1, 2025

Language: Английский

Citations

0
Mitochondria-localized iridium(III) complexes as chemotherapeutic agents against melanoma DOI
Ziyang Liu, Qixuan Zhang,

Yang Yixiong

et al.

Polyhedron, Journal Year: 2025, Volume and Issue: unknown, P. 117527 - 117527

Published: April 1, 2025

Language: Английский

Citations

0
Photo-Activated Ferrocene-Iridium(III) Prodrug Induces Immunogenic Cell Death in Melanoma Stem Cells DOI

Qiaoshan Lie,

Hui Jiang, Xiangwan Lu

et al.

Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 15, 2025

Cancer stem cells (CSCs) are key contributors to tumor resistance, recurrence, and metastasis. Conventional chemotherapy often fails target eradicate CSCs, significantly impairing their therapeutic efficacy. Herein, we design synthesize a photoactivated ferrocene-iridium(III) complex (Ir-3) achieve immunotherapy against melanoma (including cells). In short, Ir-3 effectively targets mitochondria dissociates under light irradiation produce cytotoxic Ir(III) photosensitizer Fe2+ ions. They can generate reactive oxygen species by the Fenton reaction, robustly induce ferroptosis autophagy, eventually trigger immunogenic cell death in Furthermore, exposure, inhibits cell-related properties promotes macrophage-mediated phagocytosis of cells. For vivo studies, is encapsulated DSPE-PEG 2000 form tumor-targeting Ir-3@PEG nanoparticles. After photoactivation, inhibit primary distant tumors, stemness cells, innate adaptive immune responses.

Language: Английский

Citations

0
Rhodium(III) Complex Noncanonically Potentiates Antitumor Immune Responses by Inhibiting Wnt/β-Catenin Signaling DOI

Feng-Yang Wang,

Liang-Mei Yang,

Xiaolin Xiong

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 67(16), P. 13778 - 13787

Published: Aug. 12, 2024

Metal-based chemoimmunotherapy has recently garnered significant attention for its capacity to stimulate tumor-specific immunity beyond direct cytotoxic effects. Such effects are usually caused by ICD via the activation of DAMP signals. However, metal complexes that can elicit antitumor immune responses other than have not yet been described. Herein, we report a rhodium complex (

Language: Английский

Citations

3
Recent Advances of Metal Complexes in the Treatment of Hepatocellular Carcinoma DOI
Zhongren Xu, Yu Liu, Jiaqi Yang

et al.

Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 16, 2024

Chemotherapy has long been used in the clinical management of hepatocellular carcinoma (HCC), driving development anticancer chemotherapy drugs. Platinum complexes have attracted significant attention and led to creation a series platinum-based drugs diverse cancer treatments, including HCC. However, use platinum faces critical challenges due drug resistance side effects. Consequently, ongoing efforts devoted continuous new metal with antitumor properties, aiming serve as effective alternatives for HCC treatment. In this Perspective, we summarize highlight progress relevant mechanisms related treatment over past decade. The potential further expand scope applications

Language: Английский

Citations

3
More than just DNA damage: Pt(ΙΙ)-NHC complexes derived from 4,5-diarylimidazoles augment immunogenic cell death DOI
Lu Tang, Xingyu Chang, Jing Shi

et al.

European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 282, P. 117014 - 117014

Published: Nov. 12, 2024

Language: Английский

Citations

1
Rational Design of Chloride-Based Ionic Iridium(III) Complex to Construct Phosphorescent Nanoparticles for Cancer Cell Imaging DOI
Xiaoli Li,

Mengyao He,

Rui Liu

et al.

Journal of Organometallic Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 123485 - 123485

Published: Dec. 1, 2024

Language: Английский

Citations

1
Endocytic Uptake of Self‐Assembled Iridium(III) Nanoaggregates for Holistic Treatment of Metastatic 3D Triple‐Negative Breast Tumor Spheroids DOI
Ayushi Chaudhary, Ashwini Kumar, Nirmal Keshari Swain

et al.

Small, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Abstract Triple‐negative breast cancer (TNBC) presents a formidable challenge due to its aggressive behavior and limited array of treatment options available. This study focuses on employing nanoaggregate material organometallic Ir(III) complexes for treating TNBC cell line MDA‐MB‐231. In this approach, with enhanced cellular permeability are strategically designed achieved through the incorporation COOMe groups into their structure. The lead compound, IrL 1 , exhibits promiscuous nanoscale aggregation in RPMI culture media, characterized by stable hydrodynamic effective diameter ranging from 190 202 nm over 48 h. With excellent photo‐responsive contrast‐enhanced imaging properties an outstanding IC 50, 48h value 36.05± 0.03 n m when irradiated 390 light MDA‐MB‐231 (IC h Cisplatin is 5.29 µ ). cell, investigation confirms that nanoaggregates internalization via energy‐dependent endocytosis undergo ferroptosis ROS mediated death cells. Further, these vivo studies using NOD‐SCID mice confirmed tendency ablate tumors inoculated models at therapeutically relevant doses. Thus, comprehensive approach holds promise expanding repertoire adaptable characteristics, thereby advancing clinical utility nanomedicine holistic metastatic 3D triple‐negative tumor spheroids.

Language: Английский

Citations

0