Effects of waterborne antidepressants on non-target animals living in the aquatic environment: A review

The Science of The Total Environment, Journal Year: 2018, Volume and Issue: 631-632, P. 789 - 794

Published: March 18, 2018

Language: Английский

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A review of the pharmaceutical exposome in aquatic fauna

Environmental Pollution, Journal Year: 2018, Volume and Issue: 239, P. 129 - 146

Published: April 10, 2018

Pharmaceuticals have been considered 'contaminants of emerging concern' for more than 20 years. In that time, many laboratory studies sought to identify hazard and assess risk in the aquatic environment, whilst field searched targeted candidates occurrence trends using advanced analytical techniques. However, a lack systematic approach detection quantification pharmaceuticals has provided fragmented literature serendipitous approaches. Evaluation extent plethora human veterinary available requires reliable measurement trace levels contaminants across different environmental compartments (water, sediment, biota - which largely neglected). The focus on pharmaceutical concentrations surface waters other exposure media therefore limited both characterisation exposome wildlife understanding cause effect relationships. Here, we compile current approaches accumulation data review state research field. Our analysis provides evidence support 'Matthew Effect' raises critical questions about use analyte lists biomonitoring. We provide six recommendations stimulate improve future avenues.

Language: Английский

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Contaminants of emerging concern in a large temperate estuary

Environmental Pollution, Journal Year: 2016, Volume and Issue: 213, P. 254 - 267

Published: Feb. 21, 2016

Language: Английский

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Pharmacology beyond the patient – The environmental risks of human drugs

Environment International, Journal Year: 2019, Volume and Issue: 129, P. 320 - 332

Published: May 28, 2019

The presence of pharmaceuticals in the environment is a growing global concern and although environmental risk assessment required for approval new drugs Europe USA, adequacy current triggers effects-based assessments has been questioned. To provide comprehensive analysis all regulatory compliant aquatic ecotoxicity data evaluate to facilitate development more efficient approaches toxicity testing. Publicly-available targeting human proteins was compiled together with pharmacological information including drug targets, Cmax lipophilicity. Possible links between these factors effects on, growth, mortality and/or reproduction, were evaluated. risks then assessed based on combined predicted concentrations European patient consumption data. For most (88%) 975 approved small molecule complete set public domain lacking, highlighting need both intelligent prioritize legacy tailored transparent database that captures We show presence/absence drug-target orthologues are predictive susceptible species potent drugs. Drugs target endocrine system represent highest potency greatest risk. However, (>80%) full data, quotients assuming worst-case exposure below one countries indicating low endpoints assessed. believe presented can guide improvements testing procedures, valuable prioritising (i.e. those registered before 2006) further where possible (e.g. behaviour) not captured tests, additional mechanistic may be confidence avoiding impacts.

Language: Английский

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Emerging contaminants: A One Health perspective

The Innovation, Journal Year: 2024, Volume and Issue: 5(4), P. 100612 - 100612

Published: March 13, 2024

Language: Английский

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Bioaccumulation and trophic dilution of human pharmaceuticals across trophic positions of an effluent-dependent wadeable stream

Philosophical Transactions of the Royal Society B Biological Sciences, Journal Year: 2014, Volume and Issue: 369(1656), P. 20140058 - 20140058

Published: Oct. 14, 2014

Though pharmaceuticals are increasingly observed in a variety of organisms from coastal and inland aquatic systems, trophic transfer food webs have not been reported. In this study, bioaccumulation select was investigated lower order effluent-dependent stream central Texas, USA, using isotope dilution liquid chromatography-tandem mass spectrometry (MS). A fish plasma model, initially developed laboratory studies, tested to examine versus predicted internal dose pharmaceuticals. Pharmaceuticals accumulated higher concentrations invertebrates relative fish; elevated the antidepressant sertraline its primary metabolite desmethylsertraline were Asian clam, Corbicula fluminea, two unionid mussel species. Trophic positions determined stable isotopes (δ(15)N δ(13)C) collected by ratio-MS; Bayesian mixing model then used estimate diet contributions towards top predators. Because diphenhydramine carbamazepine only target compounds detected all species examined, magnification factors (TMFs) derived evaluate potential both compounds. TMFs for (0.38) (1.17) indicated neither compound experienced magnification, which suggests that inhalational dietary exposure represented route uptake stream.

Language: Английский

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Global scanning of selective serotonin reuptake inhibitors: occurrence, wastewater treatment and hazards in aquatic systems

Environmental Pollution, Journal Year: 2019, Volume and Issue: 250, P. 1019 - 1031

Published: April 27, 2019

Language: Английский

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Reviewing the serotonin reuptake inhibitors (SSRIs) footprint in the aquatic biota: Uptake, bioaccumulation and ecotoxicology

Environmental Pollution, Journal Year: 2014, Volume and Issue: 197, P. 127 - 143

Published: Dec. 18, 2014

Language: Английский

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Bioaccumulation of pharmaceuticals and personal care product chemicals in fish exposed to wastewater effluent in an urban wetland

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: Nov. 29, 2017

The bioaccumulation of a broad range pharmaceuticals and personal care product chemicals (PPCPs) was studied in Cootes Paradise Marsh (CPM), an urban wetland that receives tertiary treated municipal waste waters as well storm runoff. We measured PPCPs caged wild goldfish, carp, compared observed factors (BAFP) using concentrations surface fish blood plasma, with modeled BAFs. Thirty-two were detected water from the central CPM site (CPM3) while 64 found at higher immediately downstream effluent outflow (CPM1). Following 3-week deployment, 15 plasma goldfish CPM1, 14 CPM3, to only 3 reference site. highest BAFP for antidepressant Σfluoxetine averaging 386 L/kg 906 respectively. In ΣDiazepam (diazepam oxazepam) had (927 L/kg). This study identified broader than previously reported. However, BAFs did not show good agreement whole body or BAFs, demonstrating more work is needed better explain PPCPs.

Language: Английский

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The effects of antidepressants appear to be rapid and at environmentally relevant concentrations

Environmental Toxicology and Chemistry, Journal Year: 2015, Volume and Issue: 35(4), P. 794 - 798

Published: May 29, 2015

The effects of antidepressants on wildlife are currently raising some concern because an increased number publications indicating biological at environmentally relevant concentrations (<100 ng/L). These results have been met with scepticism the higher required to detect in species and perceived slowness therapeutic recorded humans other vertebrates. Because their mode action is thought be by modulation neurotransmitters serotonin, dopamine, norepinephrine, aquatic invertebrates that possess transporters receptors sensitive activation these pharmaceuticals potentially affected them. authors highlight studies antidepressants, particularly crustacean molluskan groups, showing they susceptible a wide variety neuroendocrine disruptions concentrations. Interestingly, observed can within minutes hours exposure. For example, exposure amphipod crustaceans several selective serotonin reuptake inhibitors invoke changes swimming behavior hours. In mollusks, induce spawning male female mussels foot detachment snails light new human brain from using magnetic resonance imaging scans, discuss possible reasons for discrepancy former relation read-across hypothesis, variation biomarkers used, modes uptake, phylogenetic distance, affinity different targets differential sensitivity receptors.

Language: Английский

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