Journal of Hazardous Materials,
Journal Year:
2024,
Volume and Issue:
470, P. 134179 - 134179
Published: March 30, 2024
Microplastics
(MPs)
and
fluoxetine
are
ubiquitous
emerging
pollutants
in
aquatic
environments
that
may
interact
with
each
other
due
to
the
carrier
effects
of
MPs,
posing
unpredictable
risks
non-target
organisms.
However,
limited
studies
have
focused
on
MPs
food
chain.
This
study
evaluated
influences
polystyrene
trophic
transfer
biotoxicity
a
simple
chain
composed
brine
shrimp
(Artemia
nauplii)
zebrafish
(Danio
rerio).
The
findings
revealed
enhanced
accumulation
waterborne
shrimp,
but
suppressed
distinct
retention
times.
accumulated
was
further
transferred
fish
through
chain,
which
alleviated
by
their
cleaning
effects.
In
addition,
specific
neurotransmission
induced
mitigated
whilst
oxidative
damage,
apoptosis,
immune
responses
were
reversely
stimulating
effect.
These
highlight
alleviating
providing
new
insights
into
context
increasing
global
MP
pollution.
microplastics
attracted
rapidly
attention
potential
threats
organisms,
particularly
knowledge
regarding
is
still
poorly
understood
Herein,
we
investigated
co-existing
results
finding
provides
under
microplastic
Ecotoxicology and Environmental Safety,
Journal Year:
2024,
Volume and Issue:
277, P. 116359 - 116359
Published: April 24, 2024
2,6-Dihalogenated
nitrophenols
(2,6-DHNPs)
are
emerging
halogenated
nitroaromatic
pollutants
that
have
been
detected
in
various
water
environments.
However,
there
is
currently
limited
research
available
regarding
their
potential
impacts
on
locomotion
behavior
and
neurotoxicity.
Therefore,
this
study
utilized
zebrafish
embryos
to
investigate
the
neurotoxic
effects
of
2,6-DHNPs
by
examining
impact
nervous
system
at
a
concentration
defined
as
10%
median
lethal
concentration.
Our
findings
demonstrated
exposure
resulted
significant
30
%
decrease
total
swimming
distance
larvae,
accompanied
notable
impairments
motor
neuron
development
central
system.
These
were
evidenced
substantial
25%
axonal
growth,
well
disruptions
synapse
formation
neuronal
differentiation.
Additionally,
neurotransmitter
analysis
revealed
marked
decreases
40%,
35%,
30%
dopamine,
5-hydroxytryptamine,
acetylcholine
levels
respectively,
highlighting
disturbances
synthesis,
transport,
degradation
mechanisms.
results
emphasize
considerable
neurotoxicity
concentrations
previously
considered
safe;
thus
necessitating
re-evaluation
environmental
risk
assessments
regulatory
standards
for
such
contaminants.
Environmental Pollution,
Journal Year:
2024,
Volume and Issue:
357, P. 124439 - 124439
Published: June 26, 2024
Emerging
pollutants,
such
as
pharmaceuticals
and
microplastics
have
become
a
pressing
concern
due
to
their
widespread
presence
potential
impacts
on
ecological
systems.
To
assess
the
ecosystem-level
effects
of
these
pollutants
within
multi-stressor
context,
we
simulated
real-world
conditions
by
exposing
near-natural
multi-trophic
aquatic
food
web
gradient
environmentally
relevant
concentrations
fluoxetine
in
large
mesocosms
over
period
more
than
three
months.
We
measured
biomass
abundance
different
trophic
groups,
well
functions
nutrient
availability
decomposition
rate.
explore
mechanisms
underlying
community
effects,
also
performed
behavioral
assays
focusing
locomotion
parameters
response
variable
species:
Daphnia
magna
(zooplankton
prey),
Chaoborus
flavicans
larvae
(invertebrate
pelagic
predator
zooplankton)
Asellus
aquaticus
(benthic
macroinvertebrate),
using
water
from
mesocosms.
Our
mesocosm
results
demonstrate
that
governs
phytoplankton
biomass,
with
weak
non-monotonic
dose-response
relationship
interaction
between
fluoxetine.
However,
exposure
evoked
strong
zooplankton
microbial
rate
plant
material.
In
assays,
prey
D.
showed
similar
primarily
induced
Its
C.
flavicans,
however,
significant
governed
both
The
behavior
decomposer
A.
significantly
decreased
at
higher
concentrations,
potentially
leading
reduced
rates
near
sediment.
study
demonstrates
observed
upon
short-term
result
pronounced
following
chronic
exposure.
The Science of The Total Environment,
Journal Year:
2023,
Volume and Issue:
903, P. 166078 - 166078
Published: Aug. 11, 2023
Antidepressants
widely
occur
as
emerging
contaminants
in
marine
coastal
waters,
with
concentrations
reported
the
low
ng/L
range.
Although
at
relatively
lower
levels
respect
to
other
pharmaceuticals,
antidepressants
-
fluoxetine
(FLX)
particular
have
attracted
attention
because
of
their
striking
effects
exerted
doses
on
invertebrates.
In
this
study,
four
including
FLX,
sertraline
(SER),
and
citalopram,
members
selective
serotonin
reuptake
inhibitor
(SSRI)
class,
venlafaxine
(VEN)
a
member
norepinephrine
(SNRI)
were
evaluated
mussel
Mytilus
galloprovincialis.
addition,
two
main
metabolites
FLX
VEN,
i.e.,
norfluoxetine
(NFL)
O-desmethylvenlafaxine
(ODV)
respectively,
compared
those
parent
compounds.
Eight
each
drug
(0.5-500
range)
tested
early
life
stage
endpoints
gamete
fertilization
larval
development
48
h
post
(hpf).
Egg
was
reduced
by
all
compounds,
except
for
VEN.
Larval
hpf
affected
SSRIs,
but
not
SNRIs.
The
above
significant
never
exceeded
20
%
control
values.
Adult
mussels
exposed
vivo
7
days
environmental
drugs
(0.5,
5,
10
ng/L)
battery
eight
biomarkers
assessed.
primarily
targeted
lysosomal
functions,
decreasing
haemocyte
lysosome
membrane
stability
(up
70
reduction)
increasing
lysosome/cytosol
ratio
220
%),
neutral
lipid
230
lipofuscin
440
%)
accumulation
digestive
gland.
Only
SER
NFL
significantly
catalase
glutathione-S-transferase
activities
gills
ODV,
effective
sometimes
more
active
than
All
compounds
impaired
health
status,
indicated
high
stress
assigned
using
Mussel
Expert
System.
The
nematode
Caenorhabditis
elegans
is
a
valuable
model
for
ecotoxicological
research,
yet
limited
attention
has
been
given
to
understanding
how
it
absorbs,
distributes,
metabolizes,
and
excretes
chemicals.
This
crucial
C.
because
the
organism
known
have
strong
uptake
barriers
that
are
be
susceptible
potential
confounding
effects
of
presence
Escherichia
coli
as
food
source.
One
frequently
studied
compound
in
antidepressant
fluoxetine,
which
an
active
metabolite
norfluoxetine.
In
this
study,
we
evaluated
toxicokinetics
relative
potency
norfluoxetine
fluoxetine
chemotaxis
activity
tests.
Toxicokinetics
experiments
were
conducted
with
varying
times,
concentrations
absence
or
E.
coli,
simulated
one-compartment
model.
Our
findings
demonstrate
can
take
up
convert
into
Norfluoxetine
proved
slightly
more
potent
had
longer
elimination
half-life.
bioconcentration
factor,
uptake,
rate
constants
depended
on
exposure
levels,
duration,
medium.
These
expand
our
toxicokinetic
modeling
different
scenarios,
underlining
importance
considering
formation
bioactivity
assessments
fluoxetine.
Receptors,
Journal Year:
2024,
Volume and Issue:
3(1), P. 1 - 12
Published: Jan. 4, 2024
Major
depression
is
related
to
dysfunction
of
the
GABAergic
pathway.
Interestingly,
antidepressant
fluoxetine
modifies
neurotransmission
in
human
and
animal
models
depression.
However,
effects
norfluoxetine
(the
main
metabolite
fluoxetine)
on
have
not
yet
been
studied.
Therefore,
we
explored
whether
and/or
may
regulate
transmission
these
substances
interact
with
GABAA
receptors
hippocampal
CA1
stratum
radiatum
interneurons.
For
purposes,
recorded
firing
profile,
spontaneous
inhibitory
postsynaptic
currents
(sIPSCs),
induced
by
GABA
puffs
interneurons
using
both
whole-cell
current-
voltage-clamp
techniques.
Interneurons
were
selected
according
their
high
profile.
We
found
that
(at
20
µM)
significantly
decreased
frequency
sIPSCs
without
modifying
amplitude
GABA-induced
currents.
These
results
indicate
decrease
release
from
neurons
contacting
negatively
modulate
interneurons,
resulting
disinhibition,
which
turn
contribute
increasing
inhibition
pyramidal
neurons.
