Mentha pulegium as a source of green synthesis of nanoparticles with antibacterial, antifungal, anticancer, and antioxidant applications

Scientia Horticulturae, Journal Year: 2023, Volume and Issue: 320, P. 112215 - 112215

Published: June 10, 2023

Language: Английский

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Recent trends in the use of cobalt ferrite nanoparticles as an antimicrobial agent for disability infections: A review

Inorganic Chemistry Communications, Journal Year: 2023, Volume and Issue: 156, P. 111187 - 111187

Published: Aug. 6, 2023

Language: Английский

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Recent Advances in Understanding the Molecular Mechanisms of Multidrug Resistance and Novel Approaches of CRISPR/Cas9-Based Genome-Editing to Combat This Health Emergency

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 1125 - 1143

Published: Feb. 1, 2024

Abstract: The rapid spread of multidrug resistance (MDR), due to abusive use antibiotics has led global health emergency, causing substantial morbidity and mortality. Bacteria attain MDR by different means such as antibiotic modification/degradation, target protection/modification/bypass, enhanced efflux mechanisms. classical approaches counteracting bacteria are expensive time-consuming, thus, it is highly significant understand the molecular mechanisms this curb problem from core level. revolutionary approach clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated sequence 9 (CRISPR/Cas9), considered a next-generation genome-editing tool presents an innovative opportunity precisely edit bacterial genome alter their strategy. Different possessing genes mec A, erm B, ram R, tet mqr B bla KPC that have been targeted CRISPR/Cas9 re-sensitize these pathogens against antibiotics, methicillin, erythromycin, tigecycline, colistin carbapenem, respectively. S. pyogenes most widely studied tool, consisting Cas9 DNA endonuclease associated with tracrRNA crRNA, which can be systematically coupled sgRNA. targeting strategies cells mediated through phage, plasmids, vesicles nanoparticles. However, specific challenging task still remains at very preliminary stage numerous obstacles awaiting solved. This review elaborates some recent updates about role system in modulating Furthermore, delivery discussed. In addition, challenges future prospects also described. Keywords: bacteria, resistance, CRISPR/Cas9, gene editing, nanoparticle,

Language: Английский

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The influence of efflux pump, outer membrane permeability and β-lactamase production on the resistance profile of multi, extensively and pandrug resistant Klebsiella pneumoniae

Journal of Infection and Public Health, Journal Year: 2024, Volume and Issue: 17(11), P. 102544 - 102544

Published: Sept. 16, 2024

Language: Английский

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Current Status and Perspectives of Diagnosis and Treatment of Periprosthetic Joint Infection

Infection and Drug Resistance, Journal Year: 2024, Volume and Issue: Volume 17, P. 2417 - 2429

Published: June 1, 2024

Abstract: Periprosthetic joint infection (PJI) is a catastrophic complication following replacement surgery, posing significant challenges to orthopedic surgeons. Due the lack of definitive diagnostic gold standard, timely treatment initiation problematic, resulting in substantial economic burdens on patients and society. In this review, we thoroughly analyze complexities PJI emphasize importance accurate diagnosis effective treatment. The article specifically focuses advancements techniques, ranging from traditional pathogen culture advanced molecular diagnostics, discusses their role enhancing accuracy. Additionally, review latest surgical management strategies, including everything debridement revision surgeries. Our summary aims provide practical information for encourages further research improve accuracy outcomes. Keywords: arthroplasty, periprosthetic infection, PJI, diagnosis, pathogenesis antibiotic application, recurrence

Language: Английский

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From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

Plants, Journal Year: 2023, Volume and Issue: 12(14), P. 2661 - 2661

Published: July 16, 2023

Transdermal delivery devices and wound dressing materials are constantly improved upgraded with the aim of enhancing their beneficial effects, biocompatibility, biodegradability, cost effectiveness. Therefore, researchers in field have shown an increasing interest using natural compounds as constituents for such systems. Plants, important source so-called “natural products” enormous variety structural diversity that still exceeds capacity present-day sciences to define or even discover them, been part medicine since ancient times. However, benefits just at beginning being fully exploited modern dermal transdermal Thus, plant-based primary compounds, without biological activity, contained gums mucilages, traditionally used gelling texturing agents food industry, now explored valuable cost-effective components biomedical field. Their non-toxicity compensate local availability compositional variations. Also, secondary metabolites, classified based on chemical structure, intensively investigated wide pharmacological toxicological effects. impact is highlighted detail through most recent reported studies. Innovative isolation purification techniques, new drug systems, advanced evaluation procedures presented.

Language: Английский

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A Comprehensive Review of Essential Oil–Nanotechnology Synergy for Advanced Dermocosmetic Delivery

Cosmetics, Journal Year: 2024, Volume and Issue: 11(2), P. 48 - 48

Published: March 27, 2024

This review investigates the convergence of nanotechnology and essential oils in advanced dermocosmetic delivery. It outlines pivotal role inorganic polymeric nanoparticles, such as titanium dioxide, zinc oxide, gold nanocarriers, cosmeceutical applications, facilitating slow release, deeper skin penetration, increased retention active compounds. Essential oils, renowned for therapeutic benefits, face translation challenges due to volatility low water solubility. explores potential use plant nanovesicles carriers, emphasizing safety, stability, scalability, offering a sustainable cost-effective industrial application. Nanomaterial integration consumer products, particularly cosmetics, is prevalent, with nanocarriers enhancing permeation bioactive compounds into layers. The emphasizes recent nanotechnological advancements, covering nanoparticle experimental models, applications dermatology, ranging from non-invasive vaccination transdermal drug Additionally, delves nanomaterials’ addressing aging, focusing on tissue regeneration. Nanomaterials loaded cosmeceuticals, phytochemicals vitamins, are explored promising solutions mitigate signs including wrinkles dry skin, providing innovative approaches rejuvenation. Overall, offers comprehensive synthesis oil–nanoparticle synergy, shedding light current landscape future delivery systems.

Language: Английский

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Advancing therapeutic efficacy: nanovesicular delivery systems for medicinal plant-based therapeutics

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2024, Volume and Issue: 397(10), P. 7229 - 7254

Published: May 3, 2024

Language: Английский

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Rapid biosynthesis and antibacterial activity of zinc oxide nanoparticles using fruit peel of Punica granatum L as cellulose

Current Research in Green and Sustainable Chemistry, Journal Year: 2023, Volume and Issue: 6, P. 100366 - 100366

Published: Jan. 1, 2023

A biosynthesis of zinc oxide nanoparticles (ZnONPs) is investigated by using Punica granatum (PG) fruit peels as cellulose nanocrystals (CNC). As a first step, the phytochemical properties were evaluated reducing agents and control for nanocomposites. The second step involved biosynthesizing PG–CNC–ZnONPs simple rapid method, which was then confirmed spectroscopy microscopy. In addition, antibacterial activity tested against S. aureus, E.coli, typhi, S.flexneri in vitro. E. coli flexneri had zones inhibition (mean values) 14.19 mm 14.16 mm, respectively, PG–CNC–ZnONPs. For PG–CNC–ZnONPs, minimum inhibitory concentration (MICs) that completely inhibited growth aureus 250 μg/mL, while coli, flexneri, typhi achieved at 125 31.2 15.6 μg/mL respectively. Moreover, results bactericidal (MBC) also showed lowest MBC (31.2 μg/mL) all strains. current work has advantages simplicity, low particle size, high Zn, maximum zones.

Language: Английский

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Biosynthesis cobalt‐doped nickel nanoparticles and their toxicity against disease

Microscopy Research and Technique, Journal Year: 2023, Volume and Issue: 87(2), P. 272 - 278

Published: Sept. 28, 2023

Abstract The nanostructures have the great potential for novel medical and drug delivery applications. In present paper a green approach preparation of pure nickel oxide (NiO) 5% cobalt‐doped NiO (Co╫NiO) nanoparticles (NPs) by using Prosopis fracta extract been study. product Co╫NiO NPs was proved through PXRD, Raman, UV–Vis, FESEM, EDX analyses. results XRD, EDX, UV–Visible spectra displayed well doped cobalt in NP. particle sizes were observed to be about 80 nm. MTT test cytotoxicity on breast cancer cells (MCF‐7) affirmed stronger impact NiO‐NPs compared NPs. Thus, it is indicated that doping process caused an increase its inhibitory effect against MCF‐7 cells. Research Highlights Cobalt‐doped prepared ecofriendly synthesis method their studied

Language: Английский

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