International Journal of Polymeric Materials,
Journal Year:
2023,
Volume and Issue:
73(16), P. 1401 - 1417
Published: Dec. 14, 2023
Lepidium
perfoliatum
seed
gum
(LPSG)
biopolymer
was
co-electrospun
in
a
hybrid
nanofiber
(HNF)
structure
using
polyvinyl
alcohol
and
polycaprolactone
polymers.
The
obtained
results
showed
the
improvement
hydrophilicity
of
HNFs
with
an
increase
LPSG
content.
In-vitro
assay
two
stages
degradation
(34%
4%
weight
loss
within
24
h
14
days,
respectively).
antibacterial
also
activity
against
Gram-positive
Gram-negative
bacteria
species.
biocompatibility
LPSG-based
nanofibers
justified
by
MTT
L929
fibroblast
cells
(97.4%
cell
viability).
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Journal Year:
2024,
Volume and Issue:
16(3)
Published: May 1, 2024
Abstract
Natural
bioactive
compounds
from
plants
exhibit
substantial
pharmacological
potency
and
therapeutic
value.
However,
the
development
of
most
plant
is
hindered
by
low
solubility
instability.
Conventional
pharmaceutical
forms,
such
as
tablets
capsules,
only
partially
overcome
these
limitations,
restricting
their
efficacy.
With
recent
nanotechnology,
nanocarriers
can
enhance
bioavailability,
stability,
precise
intracellular
transport
compounds.
Researchers
are
increasingly
integrating
nanocarrier‐based
drug
delivery
systems
(NDDS)
into
natural
with
significant
success.
Moreover,
products
benefit
nanotechnological
enhancement
contribute
to
innovation
optimization
via
self‐assembly,
grafting
modifications,
biomimetic
designs.
This
review
aims
elucidate
collaborative
reciprocal
advancement
achieved
botanical
products,
compounds,
polysaccharides,
proteins,
extracellular
vesicles.
underscores
salient
challenges
in
nanomedicine,
encompassing
long‐term
safety
evaluations
nanomedicine
formulations,
targeting
mechanisms,
biodistribution
complexities,
hurdles
clinical
translation.
Further,
this
study
provides
new
perspectives
leverage
nanotechnology
promoting
for
nanomedical
applications
guiding
progression
NDDS
toward
enhanced
efficiency,
precision,
safety.
article
categorized
under:
Therapeutic
Approaches
Drug
Discovery
>
Emerging
Technologies
Nanotechnology
Biology
Nanoscale
Systems
Journal of Angiotherapy,
Journal Year:
2024,
Volume and Issue:
8(1)
Published: Jan. 22, 2024
A
wound
is
a
disruption
in
the
continuity
of
skin
caused
by
accident,
disease,
or
surgery.
Wound
treatment
vital,
ongoing
biologically
and
physiologically
method
that
reacts
to
cell
injury.
Regarding
health,
economy,
social
aspects,
significant
impact
wounds
on
individuals
society
underscores
need
for
research
identify
innovative
therapeutic
actors
might
improve
wounds.
Postbiotics,
recent
addition
biotics
category,
are
bioactive
compounds
great
value
generated
probiotics
via
metabolic
processes.
These
substances
possess
various
advantageous
properties,
such
as
immunomodulatory,
antimicrobial,
anti-inflammatory,
promote
faster
healing.
The
Simvastatin
Polymeric
Nanoparticles
(S-PNP)
were
synthesized
utilizing
nanoprecipitation
technique
enhance
solubility
medicine
its
capacity
grow
skin.
drug
data,
dissolution,
particle
dimension,
charged
surface,
broadcasting
electron
microscope
produced
S-PNP
assessed.
was
applied
hydrogel,
physical
release
behavior
controlled
environment,
penetration
across
biological
membrane
hydrogel
gel
had
been
made
administered
rats,
histological
examination
conducted.
findings
demonstrated
notable
effectiveness
expediting
rat
recovery
process,
resulting
full
epithelialization
little
invasion
inflammatory
cells.
AIP Advances,
Journal Year:
2024,
Volume and Issue:
14(9)
Published: Sept. 1, 2024
Wound
dressings
play
a
critical
role
in
promoting
healing
by
protecting
wounds
from
external
contaminants
and
providing
an
optimal
environment
for
tissue
regeneration.
Traditional
dressings,
such
as
gauze
cotton,
offer
basic
physical
barriers
but
lack
the
ability
to
maintain
moist
wound
environment,
which
is
essential
healing.
Modern
particularly
those
incorporating
electrospun
nanofibers,
have
emerged
advanced
solutions
that
can
sustain
moisture,
absorb
exudate,
support
cell
growth
migration.
This
Review
covers
recent
advances
electrospinning
technologies
design
of
composite
materials
integrate
natural
synthetic
polymers,
bioactive
agents,
nanomaterials
enhance
In
addition,
it
highlights
key
studies
demonstrating
efficacy
these
composites
various
models.
The
primary
objective
this
inspire
guide
future
research
endeavors,
address
existing
limitations,
shed
light
on
promising
prospects
field
Pharmacia,
Journal Year:
2024,
Volume and Issue:
71, P. 1 - 8
Published: July 16, 2024
Vesicular
carriers
are
a
well-established
approach
to
improving
the
technological
and
biopharmaceutical
characteristics
of
loaded
cargo.
The
current
manuscript
is
focused
on
development
evaluation
in
comparative
aspect
two
types
vesicles—ethosomes
transfersomes
with
phytoconstituent
curcumin.
formulation
variables
affecting
their
physiochemical
cytotoxic
properties
outlined
as
well.
A
series
ethosomes
based
Lipoid
S75
ethanol,
or
edge
activator,
were
prepared
using
thin
film
hydration
method
subjected
comprehensive
by
dynamic
light
scattering
(DLS)
analysis,
transmission
electron
microscopy
(TEM),
entrapment
efficiency
evaluation,
vitro
release,
cytotoxicity
studies.
Ethosomes
(4%
w/w)
ethanol
(30%
v/v)
showed
suitable
physicochemical
(hydrodynamic
diameter
578.6
nm,
monomodal
size
distribution,
high
curcumin
(78.2%)),
superior
antiproliferative
activity
compared
free
drug
transfersomal
nanocarriers.
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1294 - 1294
Published: Oct. 4, 2024
Background/Objectives:
Considering
the
antioxidant
and
antimicrobial
properties
attributed
to
compounds
in
Syzygium
cumini
extract,
this
research
aimed
advance
postoperative
therapeutic
innovations.
Specifically,
study
assessed
physicochemical
of
a
film-forming
solution
(FFS)
incorporated
with
S.
cumini,
evaluating
its
potential
for
applications.
Methods:
The
extract
was
meticulously
characterized
determine
chemical
composition,
particular
emphasis
on
concentration
phenolic
compounds.
Antioxidant
assays
were
conducted
assess
extract’s
efficacy
these
domains.
Following
this,
an
FFS
containing
formulated
evaluated
comprehensively
skin
adhesion,
mechanical
barrier
properties,
thermal
behavior.
Results:
activities
demonstrated
promising
results,
indicating
utility
as
adjunct
care.
developed
exhibited
favorable
topical
application,
including
adequate
adhesion
appropriate
pH
levels.
Moreover,
analyses
confirmed
formulation’s
stability
retention
beneficial
properties.
Conclusions:
Overall,
findings
suggest
that
cumini-loaded
holds
significant
valuable
tool
post-surgical
management.
