Huntington's
disease
(HD)
is
a
devastating
neurodegenerative
that
manifested
by
gradual
loss
of
physical,
cognitive,
and
mental
abilities.
As
the
advances,
age
has
major
impact
on
pathogenic
signature
mutant
huntingtin
(mHTT)
protein
aggregation.
This
review
aims
to
explore
intricate
relationship
between
aging,
mHTT
toxicity,
cellular
senescence
in
HD.
Scientific
data
interplay
mHTT,
HD
were
collected
from
several
academic
databases,
including
PubMed,
Google
Scholar,
Google,
ScienceDirect.
The
search
terms
employed
"AGING,"
"HUNTINGTON'S
DISEASE,"
"MUTANT
HUNTINGTIN,"
"CELLULAR
SENESCENCE."
Additionally,
gather
information
molecular
mechanisms
potential
therapeutic
targets,
was
extended
include
relevant
such
as
"DNA
DAMAGE,"
"OXIDATIVE
STRESS,"
"AUTOPHAGY."
According
research,
aging
leads
worsening
pathophysiology
through
some
processes.
result
accumulation,
promoted,
which
causes
DNA
damage,
oxidative
stress,
decreased
autophagy,
increased
inflammatory
responses.
Pro-inflammatory
cytokines
other
substances
are
released
senescent
cells,
may
worsen
neuronal
damage
course
disease.
It
been
shown
treatments
directed
at
these
pathways
reduce
symptoms
enhance
longevity
experimental
animals,
pointing
new
possibility
treating
condition.
Through
their
amplification
harmful
effects
play
crucial
roles
development
Comprehending
interplays
creates
novel
opportunities
for
measures
targeted
alleviating
enhancing
patients'
quality
life.
Biomedicine & Pharmacotherapy,
Journal Year:
2024,
Volume and Issue:
179, P. 117372 - 117372
Published: Aug. 28, 2024
Polymeric
nanoparticles
have
emerged
as
promising
contenders
for
addressing
the
intricate
challenges
encountered
in
brain
tumor
therapy
due
to
their
distinctive
attributes,
including
adjustable
size,
biocompatibility,
and
controlled
drug
release
kinetics.
This
review
comprehensively
delves
into
latest
developments
synthesizing,
characterizing,
applying
polymeric
explicitly
tailored
therapy.
Various
synthesis
methodologies,
such
emulsion
polymerization,
nanoprecipitation,
template-assisted
fabrication,
are
scrutinized
within
context
of
targeting,
elucidating
advantages
limitations
concerning
traversing
blood-brain
barrier.
Furthermore,
strategies
pertaining
surface
modification
functionalization
expounded
upon
augment
stability,
targeting
prowess
amidst
milieu
microenvironment.
Characterization
techniques
encompassing
dynamic
light
scattering,
transmission
electron
microscopy,
spectroscopic
methods
evaluate
physicochemical
attributes
engineered
Moreover,
a
comprehensive
exploration
manifold
applications
delivery,
gene
therapy,
imaging,
combination
therapies
tumours
is
undertaken.
Special
emphasis
placed
on
encapsulation
diverse
therapeutics
nanoparticles,
thereby
shielding
them
from
degradation
enabling
precise
brain.
Additionally,
recent
advancements
stimuli-responsive
multifunctional
probed
potential
personalized
medicine
theranostics
tumours.
In
essence,
this
furnishes
an
all-encompassing
overview
strides
made
tailoring
illuminating
synthesis,
characterization,
multifaceted
application.
Journal of obstetrics and women s diseases,
Journal Year:
2025,
Volume and Issue:
74(1), P. 119 - 136
Published: April 22, 2025
The
study
of
malignant
neoplasms
the
female
reproductive
system
remains
a
crucial
issue
in
modern
oncology,
requiring
new
approaches
to
diagnosis
and
treatment.
One
promising
molecular
targets
for
therapy
is
heat
shock
protein
90,
which
plays
key
role
stabilizing
oncoproteins,
regulating
cellular
stress,
modulating
signaling
pathways.
Its
overexpression
associated
with
aggressive
tumor
growth,
metastasis,
reduced
sensitivity
therapy,
poor
prognosis.
This
review
analyzes
publications
that
address
90
cervical,
ovarian,
uterine
cancer.
An
analysis
3955
papers
from
PubMed/MEDLINE,
115
studies
eLibrary,
2725
Google
Scholar
was
conducted,
covering
period
inception
these
databases
August
2024.
findings
indicate
significant
impact
on
progression,
its
ability
prevent
apoptosis,
contribution
drug
resistance.
Heat
inhibitors
are
being
actively
investigated
as
potential
therapeutic
agents
suppress
activity
this
induce
regression.
Preclinical
clinical
trials
have
demonstrated
their
efficacy
reducing
size
decreasing
risk
recurrence.
However,
toxicity
selectivity
remain
unresolved.
development
monoclonal
antibody-based
medications
targeting
may
provide
higher
specificity
reduce
adverse
effects.
Further
needed
optimize
efficacy,
improve
bioavailability
inhibitors,
identify
biomarkers
response
therapy.
Research Square (Research Square),
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 2, 2025
Abstract
Background:
Nitrogen
(N)
is
a
crucial
element
for
plant
growth,
and
N
fertilizer
serves
as
the
primary
source
of
during
rice
growth.
The
accumulation
flavonoid
compounds
in
purple
grains
key
feature
that
increases
their
nutritional
value.
However,
mechanisms
underlying
these
flavonoids,
particularly
under
low-N
conditions,
remain
unclear.
To
investigate
synthesis
levels
pathways
flavonoids
varying
levels,
this
study
utilized
Yangzinuo
1
hao
(YZN1)
cultivar
research
material.
Flavonoid,
total
phenolic
(TP),
oligomeric
proanthocyanidin
(OPC)
contents,
along
with
antioxidant
capacity,
were
measured
from
plants
grown
four
levels.
Additionally,
changes
metabolites
analyzed
via
nontargeted
metabolomics.
Results:
findings
revealed
exhibited
significantly
higher
flavonoid,
TP,
OPC
contents
greater
capacity
N0
treatment
(0
kg
hm⁻²)
showing
most
pronounced
effect.
Key
involved
phenylpropanoid
biosynthesis
identified
conditions.
A
simplified
pathway
correlation
network
diagram
core
constructed,
highlighting
critical
nodes
metabolic
processes
Conclusions:
This
demonstrates
conditions
enhance
related
grains.
identification
construction
networks
provide
novel
insights
into
regulatory
nitrogen
limitation.
These
contribute
to
improved
strategies
management
targeted
control
rice,
offering
potential
applications
enhancing
quality
sustainable
agricultural
practices..
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(16), P. e36408 - e36408
Published: Aug. 1, 2024
One
of
the
multifactorial
worldwide
health
syndromes
is
diabetes
mellitus
which
increasing
at
a
disturbing
rate.
The
inhibition
α-glucosidase,
an
enzyme
that
catalyzes
starch
hydrolysis
in
intestine,
one
helpful
therapeutic
approach
for
controlling
hyperglycemia
related
to
type-2
diabetes.
To
discover
α-glucosidase
inhibitors,
some
2-hydrazolyl-4-thiazolidinone
hybrids
(
