The impact of ACE2 polymorphisms (rs1978124, rs2285666, and rs2074192) and ACE1 rs1799752 in the mortality rate of COVID-19 in different SARS-CoV-2 variants

Human Genomics, Journal Year: 2023, Volume and Issue: 17(1)

Published: June 16, 2023

Abstract Background Clinical severity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outcomes could be influenced by genetic polymorphisms in angiotensin I-converting enzyme ( ACE1 ) and ACE2 . This study aims to examine three (rs1978124, rs2285666, rs2074192) on the gene rs1799752 (I/D) patients who have disease 2019 (COVID-19) with various SARS-CoV-2 variants. Methods Based polymerase chain reaction-based genotyping, four genes been identified 2023 deceased 2307 recovered patients. Results The rs2074192 TT genotype was associated COVID-19 mortality all variants, whereas CT Omicron BA.5 Delta rs1978124 TC genotypes were related Alpha but variant. It found that rs2285666 CC There an association between DD ID variant mortality, there no or In variants SARS-CoV-2, CDCT TDCT haplotypes more common. Delta, CDCC TDCC linked mortality. addition CICT, TICT, TICC significantly correlated. Conclusion / had impact infection, these different effects To confirm results, however, research needs conducted.

Language: Английский

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Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy

Inflammopharmacology, Journal Year: 2023, Volume and Issue: 32(1), P. 249 - 271

Published: Nov. 13, 2023

Abstract Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of control globally. The purpose this study was evaluate clinical efficacy vitamin D (VD) in COVID-19 long COVID-19, explain discrepancy outcomes highlight potential impact metformin on VD recent articles. Articles January 2022 August 2023 were selected for review. objective achieved by reviewing, analyzing, discussing articles demonstrating (1) mechanism action (2) observational or randomized trials (RCTs) that support not beneficial effects COVID. (3) genetic non-genetic reasons variation VD. collected electronic databases such as PubMed, Scopus, MEDLINE, Google Scholar, Egyptian Knowledge Bank, Science Direct, Cochrane Database Systematic Reviews. Twenty three studies conducted vitro animal models indicated may act through protecting respiratory system antimicrobial peptide cathelicidins, reducing lung inflammation, regulating innate adaptive immune functions up regulation autophagy gene activity. Our review identified 58 met criteria. number publications supporting a activity treating 49 (86%), including 12 meta-analyses. Although total patients included all 14,071,273, role 14,029,411 (99.7%). Collectively, extensive decisive relationship between low levels severity mortality outcomes. Importantly, evidence intervention has demonstrated effectiveness supplements COVID-19. Furthermore, results 4 supported alleviating symptoms disease. However, eight RCTs one meta-analysis contain low-grade against Twenty-five have addressed association VDR DBP polymorphisms treatment failure Impaired signaling underlie variability mechanisms. Interestingly, studies, therapeutic possibly improving AMPK enhancing In conclusion, been significantly strengthened over past 18 months, with several meta-analyses reporting conclusive supplementation highlighting improve sensitivity

Language: Английский

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Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata

Clinical Cosmetic and Investigational Dermatology, Journal Year: 2025, Volume and Issue: Volume 18, P. 593 - 600

Published: March 1, 2025

Alopecia areata (AA), is a common autoimmune nonscarring alopecia. Vitamin D involved in various biological processes such as immune regulation, cellular growth, and specialization, well the maintenance of hair cycle. We aimed to explore impact different Tru9I variant genotypes on serum vitamin levels receptor (VDR) gene expression. Case-control study that included 72 individuals diagnosed with AA, along age sex matched healthy controls individuals. Blood samples were obtained measure level VDR expression focusing genotypes. Our findings indicate, for first time, possible association between "U" allele low levels, altered activity observed patients AA. This suggests complex causal relationship genetic factors Interestingly, "u" was found be significantly more prevalent control group than group, raising possibility its protective mechanism against development this disease

Language: Английский

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Single-nucleotide polymorphisms related to vitamin D metabolism and severity or mortality of COVID-19: A systematic review and meta-analysis

Gene, Journal Year: 2024, Volume and Issue: 906, P. 148236 - 148236

Published: Feb. 3, 2024

Language: Английский

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Evaluation of the association between clinical parameters and ADAM33 and ORMDL3 asthma gene single-nucleotide polymorphisms with the severity of COVID-19

International Immunopharmacology, Journal Year: 2023, Volume and Issue: 123, P. 110707 - 110707

Published: July 25, 2023

Language: Английский

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Study on the correlation between DPP9 rs2109069 and IFNAR2 rs2236757 polymorphisms with COVID-19 mortality

Nucleosides Nucleotides & Nucleic Acids, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 16

Published: April 25, 2024

Understanding the complex mechanisms of immune system in dealing with COVID-19 infection, which is probably related to polymorphism cytokine and chemokine genes, can explain pro-inflammatory condition patients. Therefore, this study, relationship between frequency single nucleotide polymorphisms two genes dipeptidylpeptidase 9 (DPP9) interferon alpha beta receptor subunit 2 (IFNAR2) severity was assessed. This study involved 954 patients, including 528 recovered 426 deceased To investigate

Language: Английский

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Vitamin D receptor gene polymorphisms role in COVID‐19 severity: Results of a Mexican patients’ cohort

International Journal of Immunogenetics, Journal Year: 2024, Volume and Issue: 51(4), P. 235 - 241

Published: April 28, 2024

Abstract Vitamin D status has been involved with coronavirus disease 19 (COVID‐19) severity. This may be mediated by vitamin metabolism regulatory genes. Of interest is the receptor (VDR) gene, which previously associated other inflammatory and respiratory diseases. In order to investigate role of VDR gene polymorphisms in COVID‐19 severity outcome, a total 292 patients were classified according moderate ( n = 56), severe 89) critical 147) and, outcome survivor 163) deceased 129), analysed for Fok I Taq polymerase chain reaction‐based restriction enzyme digestion. The single nucleotide (SNPs) not or mortality individually but when haplotype, TC was an increased risk presenting COVID‐19. Additionally, CT genotype more frequent hypertension, T allele carriers presented higher aspartate aminotransferase levels. Our results suggest relationship between SNPs Mexican population. Although there are some previous reports COVID‐19, this represents first report Latin American Further studies on populations encouraged.

Language: Английский

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Investigation of the relationship between monocyte chemoattractant protein 1 rs1024611 variant and severity of COVID-19

Cytokine, Journal Year: 2023, Volume and Issue: 171, P. 156367 - 156367

Published: Sept. 13, 2023

Language: Английский

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