Disease burden of Parkinson's disease in China and its provinces from 1990 to 2021: findings from the global burden of disease study 2021

The Lancet Regional Health - Western Pacific, Journal Year: 2024, Volume and Issue: 46, P. 101078 - 101078

Published: May 1, 2024

Parkinson's disease (PD) has become a public health concern with global ageing. However, comprehensive assessments of the temporal and geographical trend PD burden in China remain insufficient. This study aimed to examine by age, gender, region during 1990-2021.

Language: Английский

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Global, regional, and national burden of HIV and other sexually transmitted infections in older adults aged 60–89 years from 1990 to 2019: results from the Global Burden of Disease Study 2019

The Lancet Healthy Longevity, Journal Year: 2024, Volume and Issue: 5(1), P. e17 - e30

Published: Jan. 1, 2024

BackgroundSexually active older adults are often more susceptible to HIV and other sexually transmitted infections (STIs) due various health conditions (especially a weakened immune system) low use of condoms. We aimed assess the global, regional, national burdens trends STIs in from 1990 2019.MethodsWe retrieved data Global Burden Diseases, Injuries, Risk Factors Study (GBD) 2019 on incidence disability-adjusted life-years (DALYs) (syphilis, chlamydia, gonorrhoea, trichomoniasis, genital herpes) for aged 60–89 years 204 countries territories 2019. Estimated annual percentage changes age-standardised DALY rates STIs, by age, sex, Socio-demographic Index (SDI), were calculated quantify temporal trends. Spearman correlation analysis was used examine relationship between SDI.FindingsIn 2019, among globally, there an estimated 77 327 (95% uncertainty interval 59 443 97 648) new cases (age-standardised rate 7·6 [5·9 9·6] per 100 000 population) 26 414 267 (19 777 666 34 860 678) (2607·1 [1952·1 3440·8] 000). The decreased average 2·02% year CI –2·38 –1·66) remained stable (–0·02% [–0·06 0·01]) number DALYs globally 1 905 099 UI 670 056 2 242 807) 132 033 83 512 225 630) STIs. with change 0·97% –0·54 2·50) but 1·55% –1·66 –1·43) Despite global decrease people many regions showed increases, largest increases seen eastern Europe (average 17·84% [14·16 21·63], central Asia (14·26% [11·35 17·25]), high-income Pacific (7·52% [6·54 8·51]). Regionally, SDI.InterpretationAlthough either declined or regional demographic disparities. Health-care providers should be aware effects ageing societies societal factors risk adults, develop age-appropriate interventions. disparities allocation health-care resources different SDIs addressed.FundingNatural Science Foundation China, Fujian Province's Third Batch Flexible Introduction High-Level Medical Talent Teams, Technology Innovation Team (Tianshan Team) Project Xinjiang Uighur Autonomous Region, Cure Alzheimer's Fund, Helse Sør-Øst, Research Council Norway, Molecule/VitaDAO, NordForsk Foundation, Akershus University Hospital, Civitan Norges Forskningsfond Alzheimers Sykdom, Czech Republic-Norway KAPPA programme, Rosa Sløyfe/Norwegian Cancer Society & Norwegian Breast Society.

Language: Английский

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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

Scientific Reports, Journal Year: 2017, Volume and Issue: 7(1)

Published: April 11, 2017

Abstract Aging is a major international concern that brings formidable socioeconomic and healthcare challenges. Small molecules capable of improving the health older individuals are being explored. enhance cellular stress resistance promising avenue to alleviate declines seen in human aging. Tomatidine, natural compound abundant unripe tomatoes, inhibits age-related skeletal muscle atrophy mice. Here we show tomatidine extends lifespan healthspan C. elegans , an animal model aging which shares many longevity pathways with mammals. Tomatidine improves behaviors related health, including increased pharyngeal pumping, swimming movement, reduced percentage severely damaged cells. Microarray, imaging, behavioral analyses reveal maintains mitochondrial homeostasis by modulating biogenesis PINK-1/DCT-1-dependent mitophagy. Mechanistically, induces hormesis mildly inducing ROS production, turn activates SKN-1/Nrf2 pathway possibly other antioxidant response pathways, followed This mechanism occurs primary rat neurons, Our data suggest may delay some physiological aspects aging, points new approaches for pharmacological interventions diseases

Language: Английский

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Melancholy or mahjong? Diversity, frequency, type, and rural-urban divide of social participation and depression in middle- and old-aged Chinese: A fixed-effects analysis

Social Science & Medicine, Journal Year: 2019, Volume and Issue: 238, P. 112518 - 112518

Published: Aug. 26, 2019

Language: Английский

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The ageing kidney: Molecular mechanisms and clinical implications

Ageing Research Reviews, Journal Year: 2020, Volume and Issue: 63, P. 101151 - 101151

Published: Aug. 21, 2020

As human life expectancy keeps increasing, ageing populations present a growing challenge for clinical practices. Human is associated with molecular, structural, and functional changes in variety of organ systems, including the kidney. During process, kidney experiences progressive decline as well macroscopic microscopic histological alterations, which are accentuated by systemic comorbidities like hypertension diabetes mellitus, or preexisting underlying diseases. Although per se does not cause injury, physiologic normal processes likely to impair reparative capacity thus predispose older people acute disease, chronic disease other renal Mechanistically, cell senescence plays key role ageing, involving number cellular signaling mechanisms, many may be harnessed international targets slowing even reversing ageing. This review summarizes characteristics highlights latest progresses deciphering envisages potential interventional strategies novel therapeutic preventing improving hope maintaining long-term health function across course.

Language: Английский

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Social participation and depressive symptoms among Chinese older adults: A study on rural–urban differences

Journal of Affective Disorders, Journal Year: 2018, Volume and Issue: 239, P. 124 - 130

Published: June 19, 2018

Language: Английский

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Changing trends of disease burden of gastric cancer in China from 1990 to 2019 and its predictions: Findings from Global Burden of Disease Study

Chinese Journal of Cancer Research, Journal Year: 2021, Volume and Issue: 33(1), P. 11 - 26

Published: Jan. 1, 2021

China is one of the countries with heaviest burden gastric cancer (GC) in world. Understanding epidemiological trends and patterns GC can contribute to formulating effective prevention strategies.The data on incidence, mortality, disability-adjusted life-years (DALYs) from 1990 2019 were obtained Global Burden Disease Study (2019). The estimated annual percentage change (EAPC) was calculated evaluate temporal disease GC, package Nordpred R program used perform an age-period-cohort analysis predict numbers rates incidence mortality next 25 years.The number incident cases increased 317.34 thousand 612.82 2019, while age-standardized rate (ASIR) decreased 37.56 per 100,000 30.64 EAPC -0.41 [95% confidence interval (95% CI): -0.77, -0.06]. Pronounced DALYs observed. In years, new deaths are expected increase 738.79 454.80 thousand, respectively, should steadily decrease. attributable smoking different for males females.In China, despite fact that have during past three decades, increased, will continue years. Additional strategies needed reduce such as screening early detection, novel treatments, risk factors.

Language: Английский

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Long-term trends in the burden of inflammatory bowel disease in China over three decades: A joinpoint regression and age-period-cohort analysis based on GBD 2019

Frontiers in Public Health, Journal Year: 2022, Volume and Issue: 10

Published: Sept. 7, 2022

Background To study the corresponding strategies to control inflammatory bowel disease (IBD), a comprehensive assessment of burden is required. Herein, we present long-term trends in IBD China over last three decades, as well its epidemiological features. Methods We characterized using GBD 2019 methods and results, based on prevalence, incidence, mortality, years lost (YLLs), lived with disability (YLDs), disability-adjusted life (DALYs) estimated DisMod-MR 2-1. also used joinpoint age-period-cohort (apc) analysis interpret characteristics compare them global prevalence trends. Results The age-standardized incidence mortality rates both sexes changed from 1.47 (95% CI: 1.24, 1.74) 3.01 2.59, 3.50) 0.86 0.59, 1.16) 0.30 0.24, 0.35) per 100,000 people 1990 2019. DALY rate decreased 24.47 17.88, 30.19) 13.10 10.29, 16.31) average annual percentage change (AAPC) for were 2.51 2.44, 2.57), 2.53 2.41, 2.66), −3.62 −3.85, −3.39). effects age, period, cohort differed. Conclusions increasing are contributed by reduction DALYs, compounded rise between China. will be major public health challenge, given country's large population base aging population.

Language: Английский

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Global trends in total fertility rate and its relation to national wealth, life expectancy and female education

BMC Public Health, Journal Year: 2022, Volume and Issue: 22(1)

Published: July 14, 2022

Abstract Objectives Along with the development of times and progress society, total fertility rate (TFR) markedly changed in each country. Therefore, it is critical to describe trend TFR explore its influencing factors. However, previous studies did not consider time lag cumulative effect associations between factors TFR. Thus, our study aimed analyze from a new dimension. Methods The was employed using national-level data World Bank United Nations Development Programme. Distributed non-linear models 5-year were used examine independent relevant Results exposure-TFR curves inverted U-shaped for log gross domestic product (GDP) per capita life expectancy at birth, while exposure-response approximately linear female expected years schooling human index (HDI). worth noting that developed regions, increased slightly high level GDP capita, HDI. Conclusions Nowadays, growth HDI, are on drastic downward most regions. Besides, when levels continued increase, also showed slight rebound. governments, especially those developing countries, should take measures stimulate deal series problems caused by declining

Language: Английский

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The global, regional and national burden of stomach cancer and its attributable risk factors from 1990 to 2019

Scientific Reports, Journal Year: 2022, Volume and Issue: 12(1)

Published: July 7, 2022

Abstract We aimed to estimate the incidence, mortality, and disability-adjusted life-years (DALYs) of stomach cancer at global, regional, national levels. Stomach resulted in 1.3 million (1.2–1.4 million) incident cases, 9.5 hundred thousand (8.7–10.4 thousand) deaths, 22.2 (20.3–24.1 DALYs 2019. The age-standardized incidence rate, death rate DALY were 15.6 (14.1–17.2), 11.9 (10.8–12.8), 268.4 (245.5–290.6) per 100,000 person-years, respectively. Between 1990 2019, global decreased by − 30.5% (− 36.7 22.9), 41.9% 47.2 36.3), 45.6% 50.8 39.8), In most numbers higher among males than females. A considerable burden was attributable smoking a high-sodium diet. Although rates have decreased, continued growth absolute some regions, especially East Asia, poses major public health challenge. To address this, responses should be tailored fit each country’s unique situation. Primary secondary prevention strategies with increased effectiveness are required reduce mortality cancer, particularly populations high disease burden.

Language: Английский

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