The use of commercial computerised cognitive games in older adults: a meta-analysis

Scientific Reports, Journal Year: 2020, Volume and Issue: 10(1)

Published: Sept. 17, 2020

Brain training programs are currently one effective solution to prevent cognitive decline in healthy aging. We conducted a meta-analysis of randomized controlled trials assessing the use commercially available computerised games improve function people aged above 60 years old without impairment. 1,543 participants from sixteen studies were included meta-analysis. Statistically significant improvements observed for processing speed (SMD increased 0.40 [95% CI 0.20-0.60], p < 0.001), working memory (0.21 0.08-0.34], = executive 0.06-0.35], 0.006), and verbal (0.12 0.01-0.24, 0.031), but not attention or visuospatial abilities. No relationship between age amount was found. Commercially improving impairment over years.

Language: Английский

---

Effectiveness of Exergaming in Improving Cognitive and Physical Function in People With Mild Cognitive Impairment or Dementia: Systematic Review

JMIR Serious Games, Journal Year: 2020, Volume and Issue: 8(2), P. e16841 - e16841

Published: April 12, 2020

Individuals with mild cognitive impairment and dementia have impaired physical functions, leading to a reduced quality of life compared those without such impairment. Exergaming, which is defined as combination exercise gaming, an innovative, fun, relatively safe way in virtual reality or gaming environment. Therefore, exergaming may help people living overcome obstacles that they experience regarding regular activities.The aim this systematic review was studies on interventions administered elderly individuals dementia, summarize the results related functions balance, gait, executive function, episodic memory.We searched Cochrane Central Register Controlled Trials (CENTRAL), Medline, Embase, PsycINFO, Amed, Nursing Database for articles published from inception respective databases January 2019. We included all clinical trials review. The risk bias independently evaluated by two reviewers using Collaboration Risk Bias Non-randomized Studies Interventions tools.Ten involving 702 participants were There consistent evidence 7 low showing statistically significant effects functioning dementia. With respect 3 5 full-scale found positive results, intensity most games classified moderate.Overall, innovative tool improving function although there high heterogeneity among terms duration, frequency, platform used. moderate high. More high-quality more accurate outcome indicators are needed further exploration validation benefits population.

Language: Английский

---

Impact of mind-body interventions in older adults with mild cognitive impairment: a systematic review

International Psychogeriatrics, Journal Year: 2019, Volume and Issue: 31(5), P. 643 - 666

Published: Feb. 4, 2019

ABSTRACTBackground:Mind-body interventions have been associated with a range of positive outcomes in older adults mild cognitive impairment (MCI). The aim the present study was to review impact different non-pharmacological programs based on mind-body intervention for MCI.A comprehensive search method as required by Cochrane Collaboration has performed through following databases: Google Scholar, Science Direct, PubMed, PsycINFO, MEDLINE, EMBASE, CINHAL, Cochrane, Ebsco. We included studies that evaluated such mindfulness or meditation, yoga, Tai Chi and Qigong function everyday functionality non-hospitalized aged 55 years over MCI.Nine met inclusion criteria. Results indicated improved function, activities functioning, mindfulness, well resulting moderate reduction fall risk, depression stress lower risk dementia at one year.Several focused broadly yoga training studied. This shows memory, resilience MCI. However, conclusions faced limitations, small sample size, heterogeneity outcome measures, lack an active control group absence long-term follow up. Further high-quality evidence is needed order determine whether are cost-effective improving decline MCI delaying rapid progression from Alzheimer other types dementia.

Language: Английский

---

Effects of Virtual Reality Intervention on Cognition and Motor Function in Older Adults With Mild Cognitive Impairment or Dementia: A Systematic Review and Meta-Analysis

Frontiers in Aging Neuroscience, Journal Year: 2021, Volume and Issue: 13

Published: May 5, 2021

Background: Virtual reality (VR) intervention is an innovative and efficient rehabilitative tool for patients affected by stroke, Parkinson's disease, other neurological disorders. This meta-analysis aims to evaluate the effects of VR on cognition motor function in older adults with mild cognitive impairment or dementia. Methods: Seven databases were systematically searched relevant articles published from inception April 2020. Randomized controlled trials examining dementia aged &gt;60 years included. The primary outcome study was function, including overall cognition, global attention, executive memory, visuospatial ability. secondary consisting balance, gait. A subgroup analysis also performed based characteristics identify potential factors heterogeneity. Results: Eleven studies 359 participants included final analysis. Primary showed a significant moderate positive effect size (ES) ( g = 0.45; 95% confidence interval (CI) 0.31–0.59; P &lt; 0.001), attention/execution 0.49; CI 0.26–0.72; memory 0.57; 0.29–0.85; 0.32; 0.06–0.58; 0.02). Secondary small ES 0.28; 0.05–0.51; 0.018). balance 0.43; 0.06–0.80; 0.02) moderate. ability gait not significant. In analysis, heterogeneity detected type immersion population diagnosis. Conclusions: beneficial non-pharmacological approach improve dementia, especially attention/execution, balance. does show superiority performance.

Language: Английский

---

Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascular cognitive impairment: a randomized controlled trial

Clinical Rehabilitation, Journal Year: 2018, Volume and Issue: 33(1), P. 54 - 63

Published: Aug. 1, 2018

Objective: This study evaluated the possible effect of combined intervention physical exercise and cognitive training on function in stroke survivals with vascular impairment. Design: A single-blind (investigator-blinded but not subject-blinded) randomized controlled trial. Setting: Medical Rehabilitation Center Shanghai General Hospital, China. Subjects: total 225 patients (mean age 64.59 years, SD = 4.27) who exhibited impairment were included this study. Interventions: Patients randomly allocated into one four groups: (1) ( n 56; 50-minute session), (2) 57; 60-minute (3) 55; session + or (4) control groups 45-minute session). All participants received for 36 sessions, three days per week, 12 weeks. Primary measures: Measures recorded at baseline, after a six-month follow-up. measurements Trail Making Part B, Stroop, forward digit span, mental rotation tests. Results: 179 (79.56% response rate) completed Cognitive performances all tasks group improved significantly P < 0.01). Changes performance greater than those (e.g. 13.61% vs. 2.18%, 0.003), rotation, 17.36% 0.87%, 0.002), −4.11% −0.72%, 0.026). Conclusion: The produced benefits compared to either alone survivors

Language: Английский

---

Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101479 - 101479

Published: Sept. 30, 2021

Language: Английский

---

Dance intervention effects on physical function in healthy older adults: a systematic review and meta-analysis

Aging Clinical and Experimental Research, Journal Year: 2020, Volume and Issue: 33(2), P. 253 - 263

Published: Jan. 1, 2020

Language: Английский

---

Electroencephalogram Burst-suppression during Cardiopulmonary Bypass in Elderly Patients Mediates Postoperative Delirium

Anesthesiology, Journal Year: 2020, Volume and Issue: 133(2), P. 280 - 292

Published: April 22, 2020

Background Intraoperative burst-suppression is associated with postoperative delirium. Whether this association causal remains unclear. Therefore, the authors investigated whether during cardiopulmonary bypass (CPB) mediates effects of known delirium risk factors on Methods This was a retrospective cohort observational substudy Minimizing ICU [intensive care unit] Neurological Dysfunction Dexmedetomidine-induced Sleep (MINDDS) trial. The analyzed data from patients more than 60 yr old undergoing cardiac surgery (n = 159). Univariate and multivariable regression analyses were performed to assess for associations enable inference. Delirium evaluated using abbreviated Montreal Cognitive Assessment Patient-Reported Outcomes Measurement Information System questionnaires applied cognition, physical function, global health, sleep, pain. also electroencephalogram 141). Results incidence in CPB 25% (15 60) compared 6% (5 81) without burst-suppression. In univariate analyses, age (odds ratio, 1.08 [95% CI, 1.03 1.14]; P 0.002), lowest temperature 0.79 [0.66 0.94]; 0.010), alpha power 0.65 [0.54 0.80]; &lt; 0.001), function 0.95 [0.91 0.98]; 0.007) separate 1.09 [1.02 1.16]; 0.009), 0.80 0.97]; 0.024), 0.75 [0.59 0.96]; 0.025), 3.79 [1.5 9.6]; 0.005) However, only 0.96 0.99]; 0.044), 0.73 [0.58 0.88]; 0.003), 0.61 [0.47 0.76]; 0.001) retained as predictors model. Burst-suppression 4.1 13.7]; 0.012) 1.07 [0.99 1.15]; 0.090) decreased 6.8 24.4 Hertz. Conclusions inference present study that temperature, Editor’s Perspective What We Already Know about Topic Article Tells Us That Is New

Language: Английский

---

Pathophysiological Mechanisms Explaining the Association Between Low Skeletal Muscle Mass and Cognitive Function

The Journals of Gerontology Series A, Journal Year: 2022, Volume and Issue: 77(10), P. 1959 - 1968

Published: June 6, 2022

Abstract Low skeletal muscle mass is associated with cognitive impairment and dementia in older adults. This review describes the possible underlying pathophysiological mechanisms: systemic inflammation, insulin metabolism, protein mitochondrial function. We hypothesize that central tenet this pathophysiology dysfunctional myokine secretion consequent to minimal physical activity. Myokines, such as fibronectin type III domain containing 5/irisin cathepsin B, are released by physically active cross blood–brain barrier. These myokines upregulate local neurotrophin expression brain-derived neurotrophic factor (BDNF) brain microenvironment. BDNF exerts anti-inflammatory effects may be responsible for neuroprotection. Altered due inactivity exacerbates inflammation impairs glucose potentially affecting transport of across Our working model also suggests other mechanisms. A negative balance, commonly observed adults, contributes low reflect deficient metabolism tissues. As a result age-related loss mass, decrease abundance mitochondria detriments their function lead tissue oxidative capacity. Dysfunctional excessive production reactive oxygen species, which drives stress further perpetuates dysfunction mitochondria. Both accumulation DNA mutations aging drive cellular senescence. targeted approach cognition could restore balance

Language: Английский

---

A systematic review and meta‐analysis of the prevalence and correlation of mild cognitive impairment in sarcopenia

Journal of Cachexia Sarcopenia and Muscle, Journal Year: 2022, Volume and Issue: 14(1), P. 45 - 56

Published: Dec. 18, 2022

Sarcopenia is a progressive skeletal muscle disorder involving the loss of mass and function, associated with an increased risk disability frailty. Though its prevalence in dementia has been studied, occurrence mild cognitive impairment (MCI) not well established. As MCI often prelude to dementia, our study aims investigate among individuals sarcopenia also ascertain whether independently MCI. The Cochrane Library, PubMed, Ovid, Embase Web Science were systematically searched for articles on and/or published from inception 1 February 2022. We reviewed available literature number calculated odds ratios (ORs) sarcopenia, respectively. Statistical analyses performed using meta package Stata, Version 12.0. A total 13 studies 27 428 patients included analysis. pooled participants was 20.5% (95% confidence interval [CI]: 0.140-0.269) sample 2923 cases high level heterogeneity (P < 0.001; I2 = 95.4%). overall 9.1% CI: 0.047-0.134, P 93.0%). For ORs, there 23 364 subjects mean age 73 years; adjusted OR between 1.46 1.31-1.62). Slight both ORs 0.46; 0%) noted across studies. relatively may be factor

Language: Английский

---