Brain metabolism in Alzheimer’s disease: biological mechanisms of exercise DOI Creative Commons

Longfei Xu,

Ran Liu,

Yingkai Qin

et al.

Translational Neurodegeneration, Journal Year: 2023, Volume and Issue: 12(1)

Published: June 26, 2023

Alzheimer's disease (AD) is a major subtype of neurodegenerative dementia caused by long-term interactions and accumulation multiple adverse factors, accompanied dysregulation numerous intracellular signaling molecular pathways in the brain. At cellular levels, neuronal milieu AD brain exhibits metabolic abnormalities, compromised bioenergetics, impaired lipid metabolism, reduced overall capacity, which lead to abnormal neural network activity neuroplasticity, thus accelerating formation extracellular senile plaques neurofibrillary tangles. The current absence effective pharmacological therapies for points urgent need investigate benefits non-pharmacological approaches such as physical exercise. Despite evidence that regular can improve dysfunction state, inhibit different pathophysiological associated with AD, influence pathological process exert protective effect, there no clear consensus on specific biological mechanisms underlying advantages Here, we review how exercise improves crucial processes disorders including glucose Aβ metabolism transport, iron tau pathology. How states health also presented. A better knowledge neurophysiological contribute development novel drugs improvement interventions.

Language: Английский

Prevalence and Mechanisms of Skeletal Muscle Atrophy in Metabolic Conditions DOI Open Access
Lauren Jun, Megan Robinson, Thangiah Geetha

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(3), P. 2973 - 2973

Published: Feb. 3, 2023

Skeletal muscle atrophy is prevalent in a myriad of pathological conditions, such as diabetes, denervation, long-term immobility, malnutrition, sarcopenia, obesity, Alzheimer's disease, and cachexia. This critically important topic that has significance the health current society, particularly older adults. The most damaging effect decreased quality life from functional disability, increased risk fractures, basal metabolic rate, reduced bone mineral density. Most skeletal humans contains slow oxidative, fast glycolytic fiber types. Depending on condition, either oxidative or type may be affected to greater extent. review article discusses prevalence several mechanisms, with an emphasis high-fat, high-sugar diet patterns, but including other conditions cancer cachexia, heart failure.

Language: Английский

Citations

43
Exercise mimetics: a novel strategy to combat neuroinflammation and Alzheimer’s disease DOI Creative Commons
Renqing Zhao

Journal of Neuroinflammation, Journal Year: 2024, Volume and Issue: 21(1)

Published: Feb. 2, 2024

Abstract Neuroinflammation is a pathological hallmark of Alzheimer’s disease (AD), characterized by the stimulation resident immune cells brain and penetration peripheral cells. These inflammatory processes facilitate deposition amyloid-beta (Aβ) plaques abnormal hyperphosphorylation tau protein. Managing neuroinflammation to restore homeostasis decrease neuronal damage therapeutic approach for AD. One way achieve this through exercise, which can improve function protect against neuroinflammation, oxidative stress, synaptic dysfunction in AD models. The neuroprotective impact exercise regulated various molecular factors that be activated same as administration their mimetics. Recent evidence has proven some mimetics effective alleviating AD, and, additionally, they are helpful alternative option patients who unable perform regular physical manage neurodegenerative disorders. This review focuses on current state knowledge mimetics, including efficacy, regulatory mechanisms, progress, challenges, limitations, future guidance application therapy.

Language: Английский

Citations

19
Evolving therapeutic interventions for the management and treatment of Alzheimer’s disease DOI
Faizan Ahmad, Anik Karan, Rashi Sharma

et al.

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 95, P. 102229 - 102229

Published: Feb. 15, 2024

Language: Английский

Citations

16
Impact of physical exercise on the regulation of brain-derived neurotrophic factor in people with neurodegenerative diseases DOI Creative Commons

Ana Romero Garavito,

Vicente Martı́nez, Enric Cortés

et al.

Frontiers in Neurology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 28, 2025

This review explores the impact of physical exercise on brain-derived neurotrophic factor (BDNF) and its relationship with neurodegenerative diseases. The key role BDNF in maintaining brain health is highlighted, recent studies are analyzed that indicate an increase levels following activity, particularly young adults. Additionally, interaction between Val66Met genetic polymorphism cognitive function examined. emphasizes possibility as a complementary therapy for diseases, although further research required to fully understand effects.

Language: Английский

Citations

3
Effects of physical exercise on plasma brain-derived neurotrophic factor in neurodegenerative disorders: A systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
David Ruiz‐González, Alba Hernández‐Martínez, Pedro L. Valenzuela

et al.

Neuroscience & Biobehavioral Reviews, Journal Year: 2021, Volume and Issue: 128, P. 394 - 405

Published: June 1, 2021

Neurodegenerative disorders are associated with reduced levels of brain-derived neurotrophic factor (BDNF). We aimed to assess the effect exercise interventions on plasma BDNF in individuals neurodegenerative disorders. Eighteen randomized controlled trials (RCT) assessing effects versus no (i.e., multiple sclerosis, Parkinson's disease, mild cognitive impairment [MCI] and Alzheimer's disease) were included. Overall, induced a significant increase (SMD=2.22, 95% CI=1.33-3.12, p<0.001; 18 studies), which was separately confirmed for sclerosis (SMD= 2.40, CI= 1.30-3.50, 10 studies) disease 10.00, 2.48-17.51, p=0.009; 3 non-significant trend also observed MCI 1.07, -0.14-2.28, p=0.080; 4 studies). significantly increased regardless type (p<0.001, p=0.003 p=0.020 combined, aerobic resistance exercise, respectively), weekly volume (p<0.001 both ≥150 <150 min/week) intervention length ≥12 <12 weeks). In conclusion, physical PROSPERO registration number: CRD42020199459.

Language: Английский

Citations

100
Exercise interventions in Alzheimer’s disease: A systematic review and meta-analysis of randomized controlled trials DOI
Susana López‐Ortiz, Pedro L. Valenzuela, María M. Seisdedos

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 72, P. 101479 - 101479

Published: Sept. 30, 2021

Language: Английский

Citations

91
The protective role of exercise against age-related neurodegeneration DOI
Alyson Sujkowski,

Luke Hong,

Robert Wessells

et al.

Ageing Research Reviews, Journal Year: 2021, Volume and Issue: 74, P. 101543 - 101543

Published: Dec. 17, 2021

Language: Английский

Citations

90
The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection DOI Open Access
Johannes Burtscher, Grégoire P. Millet, Nicolas Place

et al.

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(12), P. 6479 - 6479

Published: June 17, 2021

Regular exercise is associated with pronounced health benefits. The molecular processes involved in physiological adaptations to are best understood skeletal muscle. Enhanced mitochondrial functions muscle central exercise-induced adaptations. However, regular also benefits the brain and a major protective factor against neurodegenerative diseases, such as most common age-related form of dementia, Alzheimer’s disease, or motor disorder, Parkinson’s disease. While there evidence that induces signalling from brain, mechanistic understanding crosstalk along muscle–brain axis incompletely understood. Mitochondria both organs, however, seem be players. Here, we provide an overview on role mitochondria communication routes brain. These include circulating factors, myokines, release which often depends mitochondria, possibly direct transfer. On this basis, examine reported effects different modes features highlight their expected regard neurodegeneration prevention mitigation. In addition, knowledge gaps our current related diseases outlined.

Language: Английский

Citations

83
New therapeutics beyond amyloid-β and tau for the treatment of Alzheimer’s disease DOI Open Access
Feng Zhang, Rujia Zhong, Cheng Cheng

et al.

Acta Pharmacologica Sinica, Journal Year: 2020, Volume and Issue: 42(9), P. 1382 - 1389

Published: Dec. 2, 2020

Language: Английский

Citations

73
Objectively assessed physical activity and sedentary behavior and global cognitive function in older adults: a systematic review DOI Creative Commons
Anna G.M. Rojer, Keenan A. Ramsey, Elvira S Amaral Gomes

et al.

Mechanisms of Ageing and Development, Journal Year: 2021, Volume and Issue: 198, P. 111524 - 111524

Published: June 25, 2021

Both physical activity (PA) and sedentary behavior (SB) are important factors for healthy ageing. This systematic review aimed to determine the association of objectively assessed (instrumented) PA SB with global cognitive function in older adults.PubMed, Embase, Cochrane Library (via Wiley), CINAHL, PsychINFO, SPORTDiscus EBSCO) were searched from inception June 21, 2020 articles that described associations PA/SB adults aged 60 years older. Results synthesized using an effect direction heat map albatross plots portrayed estimated sizes (standardized regression coefficients (βs)), which summarized boxplots.In total, 45 included representing a total 15,817 (mean/median age ranged 65 88 years; 49.5% female). Longitudinal studies (n = 7) showed higher moderate-to-vigorous light (MVPA LPA, respectively) lower associated better function. Standardized βs cross-sectional 38) (median [IQR], β 0.078 [0.004-0.184] LPA (β 0.096 [0.046-0.188]), counts 0.131 [0.049-0.224]), number steps 0.155 [0.096-0.246]), MVPA 0.163 [0.069-0.285]) (TPA) 0.174 [0.147-0.255]) function.Higher adults. The greatest found TPA, suggesting greater duration any PA, high intensity could be most beneficial

Language: Английский

Citations

66