Physical activity for cognitive health promotion: An overview of the underlying neurobiological mechanisms

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 86, P. 101868 - 101868

Published: Feb. 2, 2023

Language: Английский

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Exploring the impact of exercise-induced BDNF on neuroplasticity in neurodegenerative and neuropsychiatric conditions

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: Jan. 20, 2025

Language: Английский

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Molecular mechanisms of exercise contributing to tissue regeneration

Signal Transduction and Targeted Therapy, Journal Year: 2022, Volume and Issue: 7(1)

Published: Nov. 30, 2022

Abstract Physical activity has been known as an essential element to promote human health for centuries. Thus, exercise intervention is encouraged battle against sedentary lifestyle. Recent rapid advances in molecular biotechnology have demonstrated that both endurance and resistance training, two traditional types of exercise, trigger a series physiological responses, unraveling the mechanisms regulating on body. Therefore, expected candidate approach alleviating wide range diseases, such metabolic neurodegenerative disorders, tumors, cardiovascular diseases. In particular, capacity tissue regeneration attracted attention many researchers recent decades. Since most adult organs weak regenerative capacity, it currently key challenge medicine improve efficiency regeneration. As research progresses, exercise-induced seems provide novel fighting injury or senescence, establishing strong theoretical basis more “exercise mimetics.” These drugs are acting pharmaceutical alternatives those individuals who cannot experience benefits exercise. Here, we comprehensively description diverse organs, mainly focusing musculoskeletal system, nervous system. We also discuss underlying associated with effects emerging therapeutic mimetics regeneration, well opportunities challenges. aim describe integrated perspective current distinct various facilitate development mimics

Language: Английский

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The Impact of COVID-19 Infection on Cognitive Function and the Implication for Rehabilitation: A Systematic Review and Meta-Analysis

International Journal of Environmental Research and Public Health, Journal Year: 2022, Volume and Issue: 19(13), P. 7748 - 7748

Published: June 24, 2022

There is mounting evidence that patients with severe COVID-19 disease may have symptoms continue beyond the acute phase, extending into early chronic phase. This prolonged pathology often referred to as 'Long COVID'. Simultaneously, case investigations shown individuals might a variety of neurological problems. The accurate and accessible assessment cognitive function in post-COVID-19 infection thus increasingly high importance for both public individual health. Little known about influence on general levels but more importantly, at sub-functions level. Therefore, we first aim summarize current level supporting negative impact functions. Twenty-seven studies were included systematic review representing total 94,103 participants (90,317 3786 healthy controls). We then performed meta-analysis summarizing results five (959 participants, 513 patients) quantify overall effect, expressed standardized mean differences, -0.41 [95%CI -0.55; -0.27]. To prevent disability, finally discuss different approaches available rehabilitation help these avoid long-term complications.

Language: Английский

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The effects of long-term lactate and high-intensity interval training (HIIT) on brain neuroplasticity of aged mice

Heliyon, Journal Year: 2024, Volume and Issue: 10(2), P. e24421 - e24421

Published: Jan. 1, 2024

Extensive research has confirmed numerous advantages of exercise for promoting brain health. More recent studies have proposed the potential benefits lactate, by-product exercise, in various aspects function and disorders. However, there remains a gap understanding effects lactate dosage its impact on aged rodents. The present study first examined long-term three different doses intervention (2000 mg/kg, 1000 500 mg/kg) high-intensity interval training (HIIT) aging mice (20-22 months) as 1st experiment. Subsequently, 2nd experiment, we investigated mg/kg HIIT neuroplasticity (25-27 months). results experiment demonstrated that both (500 2000 positively impacted biomarker VEGF hippocampus mice. revealed significantly improved performance open-field, novel object recognition, passive avoidance tests. did not affect these behavioral Moreover, compared to control group, influenced angiogenesis signaling pathway (p/t-AKT/ENOS/VEGF), mitochondrial (SDHA), metabolic protein (p/t-CREB, p/t-HSL, LDH) Notably, only elevated BDNF (PGC-1α, SIRT1, BDNF) content (lactate pyruvate). In end, failed change expression p/t-MTOR, iNOS, nNOS, HIF-1α, SYNAPSIN, SIRT3, NAMPT, CS, FNDC5 Pan Lactic aid-Lysine summary, proved treatment positive functions mice, suggesting usage therapeutic strategy neurodegenerative diseases elderly population.

Language: Английский

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The microbiota-gut-brain-immune interface in the pathogenesis of neuroinflammatory diseases: a narrative review of the emerging literature

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: May 16, 2024

Importance Research is beginning to elucidate the sophisticated mechanisms underlying microbiota-gut-brain-immune interface, moving from primarily animal models human studies. Findings support dynamic relationships between gut microbiota as an ecosystem (microbiome) within (host) and its intersection with host immune nervous systems. Adding this effects on epigenetic regulation of gene expression further complicates strengthens response. At heart inflammation, which manifests in a variety pathologies including neurodegenerative diseases such Alzheimer’s disease, Parkinson’s Multiple Sclerosis (MS). Observations Generally, research date limited has focused bacteria, likely due simplicity cost-effectiveness 16s rRNA sequencing, despite lower resolution inability determine functional ability/alterations. However, omits all other fungi, viruses, phages, are emerging key members microbiome. Much been done pre-clinical and/or small studies more developed parts world. The observed promising but cannot be considered reliable or generalizable at time. Specifically, causal determined currently. More followed by then little MS. data for MS encouraging this. Conclusions relevance While still nascent, interface may missing link, hampered our progress understanding, let alone preventing, managing, putting into remission diseases. Relationships must first established humans, have shown poorly translate complex physiology environments, especially when investigating microbiome where often overly simplistic. Only can robust conducted humans using mechanistic model

Language: Английский

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miR-34a/TAN1/CREB Axis Engages in Alleviating Oligodendrocyte Trophic Factor-Induced Myelin Repair Function and Astrocyte-Dependent Neuroinflammation in the Early Stages of Alzheimer's Disease: The Anti-Neurodegenerative Effect of Treadmill Exercise

Neurochemical Research, Journal Year: 2024, Volume and Issue: 49(4), P. 1105 - 1120

Published: Jan. 30, 2024

Language: Английский

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A dose–response meta-analysis of physical activity and the risk of alzheimer’s disease in prospective studies

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 7, 2025

Language: Английский

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DNA methylation as a mediator of genetic and environmental influences on Parkinson’s disease susceptibility: Impacts of alpha-Synuclein, physical activity, and pesticide exposure on the epigenome

Frontiers in Genetics, Journal Year: 2022, Volume and Issue: 13

Published: Aug. 19, 2022

Parkinson’s disease (PD) is a neurodegenerative disorder with complex etiology and increasing prevalence worldwide. As PD influenced by combination of genetic environment/lifestyle factors in approximately 90% cases, there interest identification the interindividual mechanisms underlying development as well actionable lifestyle that can influence risk. This narrative review presents an outline environmental contributing to risk explores possible roles cytosine methylation hydroxymethylation and/or early-stage biomarkers PD, emphasis on epigenome-wide association studies (EWAS) conducted over past decade. Specifically, we focused variants SNCA gene, exposure pesticides, physical activity key contributors Current research indicates these individually impact epigenome, particularly at level CpG methylation. There also emerging evidence for interaction effects between contributions risk, possibly acting across multiple omics layers. We speculated this may be one reason poor replicability results EWAS reported date. Our goal provide direction future epigenetics build upon existing foundations leverage large datasets, new technologies, relevant statistical approaches further elucidate disease.

Language: Английский

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Neuroplasticity in Parkinson’s disease

Journal of Neural Transmission, Journal Year: 2024, Volume and Issue: 131(11), P. 1329 - 1339

Published: Aug. 5, 2024

Parkinson's disease (PD) is the second most frequent neurodegenerative disorder, affecting millions of people and rapidly increasing over last decades. Even though there no intervention yet to stop pathology, many efficient treatment methods are available, including for patients with advanced PD. Neuroplasticity a fundamental property human brain adapt both external changes internal insults pathological processes. In this paper we examine current knowledge concepts concerning at network level, cellular level molecular as parts neuroplastic response protein aggregation synapse loss neuronal in We analyse beneficial, compensatory effects, such augmentation nigral neurons efficacy, well negative, maladaptive levodopa-induced dyskinesia. Effects physical activity different treatments on neuroplasticity considered opportunity biomarkers identification use discussed.

Language: Английский

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