Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 17
Published: Aug. 31, 2022
Accumulating
evidence
has
suggested
the
significant
role
of
long
noncoding
RNAs
(lncRNA)
in
regulating
ferroptosis,
while
its
regulatory
mechanism
diabetic
retinopathy
(DR)
remains
unelucidated.
In
this
work,
we
first
demonstrated
that
lncRNA
zinc
finger
antisense
1
(ZFAS1)
is
upregulated
high
glucose-cultured
human
retinal
endothelial
cells
(hRECs)
and
ZFAS1
inhibition
attenuated
glucose-
(HG-)
induced
which
was
evidenced
by
cell
viability,
total
iron
ferrous
levels,
reactive
oxygen
species
(ROS)
level,
Glutathione
Peroxidase
4
(GPX4)
expression
detection.
Mechanistically,
validated
may
act
as
a
competing
endogenous
RNA
competitively
binding
with
microRNA-7-5p
(miR-7-5p)
modulating
downstream
molecule
acyl-CoA
synthetase
long-chain
family
member
(ACSL4),
now
identified
classic
driver
gene
ferroptosis
process.
conclusion,
our
results
demonstrate
HG-induced
elevation
activates
hRECs
ZFAS1/miR-7-5p/ACSL4
axis
serve
therapeutic
target
for
dysfunction
DR.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Feb. 21, 2023
Abstract
Parkinson’s
disease
(PD)
is
the
second
most
common
neurodegenerative
worldwide,
and
its
treatment
remains
a
big
challenge.
The
pathogenesis
of
PD
may
be
related
to
environmental
genetic
factors,
exposure
toxins
gene
mutations
beginning
brain
lesions.
identified
mechanisms
include
α-synuclein
aggregation,
oxidative
stress,
ferroptosis,
mitochondrial
dysfunction,
neuroinflammation,
gut
dysbiosis.
interactions
among
these
molecular
complicate
pose
great
challenges
drug
development.
At
same
time,
diagnosis
detection
are
also
one
obstacles
due
long
latency
complex
mechanism.
Most
conventional
therapeutic
interventions
for
possess
limited
effects
have
serious
side
effects,
heightening
need
develop
novel
treatments
this
disease.
In
review,
we
systematically
summarized
pathogenesis,
especially
PD,
classical
research
models,
clinical
diagnostic
criteria,
reported
therapy
strategies,
as
well
newly
candidates
in
trials.
We
shed
light
on
components
derived
from
medicinal
plants
that
their
treatment,
with
expectation
provide
summary
outlook
developing
next
generation
drugs
preparations
therapy.
Oxidative Medicine and Cellular Longevity,
Journal Year:
2022,
Volume and Issue:
2022, P. 1 - 17
Published: Sept. 5, 2022
Ferroptosis,
a
novel
form
of
regulated
cell
death,
is
caused
by
accumulation
lipid
peroxides
and
excessive
iron
deposition.
This
process
has
been
linked
to
the
death
dopaminergic
neurons
in
substantia
nigra
compacta
(SNc)
Parkinson's
disease
(PD)
patients.
Quercetin
(QCT),
natural
flavonoid,
multiple
pharmacological
activities.
However,
it
not
established
whether
QCT
can
protect
against
neuron
inhibiting
ferroptosis.
In
this
study,
we
investigated
potential
antiferroptotic
effects
cellular
models
using
specific
ferroptosis
inducers
(Erastin
RSL-3)
MPP+.
The
were
also
explored
MPTP-induced
PD
mouse
models.
counting
kit-8
(CCK-8)
assay
was
performed
assess
viability.
Variations
mitochondrial
morphology
evaluated
transmission
electron
microscopy
(TEM)
while
membrane
potential,
mass,
ROS
measured
fluorescent
probes.
Lipid
peroxidation
levels
assayed
through
measurement
ROS,
MDA,
GSH,
SOD
levels.
on
behavioral
disorders
examined
rotarod
open
field
tests.
vitro
vivo,
significantly
inhibited
activating
nuclear
factor
erythroid
2-related
2
(Nrf2)
protein.
Additionally,
ameliorated
motor
impairments
protected
loss
Interestingly,
Nrf2
knockdown
alleviated
protective
conclusion,
these
results
demonstrate
that
involved
MPP+/MPTP-induced
PD,
inhibits
Therefore,
agent
for
preventing
targeting
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(8), P. 4176 - 4176
Published: April 10, 2022
Parkinson’s
disease
(PD)
is
an
aging-related
and
the
second
most
common
neurodegenerative
after
Alzheimer’s
disease.
The
main
symptoms
of
PD
are
movement
disorders
accompanied
with
deficiency
neurotransmitter
dopamine
(DA)
in
striatum
due
to
cell
death
nigrostriatal
DA
neurons.
Two
histopathological
hallmarks
exist
PD:
cytosolic
inclusion
bodies
termed
Lewy
that
mainly
consist
α-synuclein
protein,
oligomers
which
produced
by
misfolding
regarded
be
neurotoxic,
causing
death;
black
pigments
neuromelanin
(NM)
contained
neurons
markedly
decrease
PD.
synthesis
human
NM
similar
melanin
melanocytes;
skin
via
DOPAquinone
(DQ)
tyrosinase,
whereas
DAquinone
(DAQ)
tyrosine
hydroxylase
(TH)
aromatic
L-amino
acid
decarboxylase
(AADC).
cytoplasm
highly
reactive
assumed
oxidized
spontaneously
or
unidentified
tyrosinase
DAQ
then,
synthesized
NM.
Intracellular
accumulation
above
a
specific
threshold
has
been
reported
associated
neuron
phenotypes.
This
review
reports
recent
progress
biosynthesis
pathophysiology
Small Methods,
Journal Year:
2022,
Volume and Issue:
6(11)
Published: Oct. 6, 2022
Abstract
Nanozymes
refer
to
nanomaterials
that
catalyze
enzyme
substrates
into
products
under
relevant
physiological
conditions
following
kinetics.
Compared
natural
enzymes,
nanozymes
possess
the
characteristics
of
higher
stability,
easier
preparation,
and
lower
cost.
Importantly,
magnetic,
fluorescent,
electrical
properties
nanomaterials,
making
them
promising
replacements
for
enzymes
in
industrial,
biological,
medical
fields.
On
account
rapid
development
recently,
their
application
potentials
regeneration
medicine
are
gradually
being
explored.
To
highlight
achievements
field,
this
review
summarizes
catalytic
mechanism
four
types
representative
nanozymes.
Then,
strategies
improve
biocompatibility
discussed.
covers
recent
advances
tissue
including
wound
healing,
nerve
defect
repair,
bone
regeneration,
cardiovascular
disease
treatment.
In
addition,
challenges
prospects
nanozyme
researches
summarized.
Advanced Science,
Journal Year:
2023,
Volume and Issue:
10(24)
Published: June 21, 2023
Emerging
evidence
suggests
that
ferroptosis,
a
unique
regulated
cell
death
modality
is
morphologically
and
mechanistically
different
from
other
forms
of
death,
plays
vital
role
in
the
pathophysiological
process
neurodegenerative
diseases,
strokes.
Accumulating
supports
ferroptosis
as
critical
factor
diseases
strokes,
pharmacological
inhibition
therapeutic
target
for
these
diseases.
In
this
review
article,
core
mechanisms
are
overviewed
roles
strokes
described.
Finally,
emerging
findings
treating
through
This
demonstrates
by
bioactive
small-molecule
compounds
(ferroptosis
inhibitors)
could
be
effective
treatments
highlights
potential
promising
avenue
used
to
prevent
article
will
shed
light
on
developing
novel
regimens
slow
down
progression
future.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 1, 2024
Abstract
Peroxisome
proliferator-activated
receptor
gamma
coactivator-1
(PGC-1)
family
(PGC-1s),
consisting
of
three
members
encompassing
PGC-1α,
PGC-1β,
and
PGC-1-related
coactivator
(PRC),
was
discovered
more
than
a
quarter-century
ago.
PGC-1s
are
essential
coordinators
many
vital
cellular
events,
including
mitochondrial
functions,
oxidative
stress,
endoplasmic
reticulum
homeostasis,
inflammation.
Accumulating
evidence
has
shown
that
implicated
in
diseases,
such
as
cancers,
cardiac
diseases
cardiovascular
neurological
disorders,
kidney
motor
system
metabolic
disorders.
Examining
the
upstream
modulators
co-activated
partners
identifying
critical
biological
events
modulated
by
downstream
effectors
contribute
to
presentation
elaborate
network
PGC-1s.
Furthermore,
discussing
correlation
between
well
summarizing
therapy
targeting
helps
make
individualized
precise
intervention
methods.
In
this
review,
we
summarize
basic
knowledge
regarding
molecular
regulatory
network,
discuss
physio-pathological
roles
human
review
application
PGC-1s,
diagnostic
prognostic
value
several
therapies
pre-clinical
studies,
suggest
directions
for
future
investigations.
This
presents
immense
potential
treatment
hopefully
facilitates
promotion
new
therapeutic
targets.
Signal Transduction and Targeted Therapy,
Journal Year:
2023,
Volume and Issue:
8(1)
Published: Dec. 10, 2023
Abstract
Ferroptosis,
a
unique
modality
of
cell
death
with
mechanistic
and
morphological
differences
from
other
modes,
plays
pivotal
role
in
regulating
tumorigenesis
offers
new
opportunity
for
modulating
anticancer
drug
resistance.
Aberrant
epigenetic
modifications
posttranslational
(PTMs)
promote
resistance,
cancer
progression,
metastasis.
Accumulating
studies
indicate
that
can
transcriptionally
translationally
determine
vulnerability
to
ferroptosis
functions
as
driver
nervous
system
diseases
(NSDs),
cardiovascular
(CVDs),
liver
diseases,
lung
kidney
diseases.
In
this
review,
we
first
summarize
the
core
molecular
mechanisms
ferroptosis.
Then,
roles
processes,
including
histone
PTMs,
DNA
methylation,
noncoding
RNA
regulation
such
phosphorylation,
ubiquitination,
SUMOylation,
acetylation,
ADP-ribosylation,
are
concisely
discussed.
The
PTMs
genesis
cancers,
NSD,
CVDs,
well
application
PTM
modulators
therapy
these
then
discussed
detail.
Elucidating
mediated
by
will
facilitate
development
promising
combination
therapeutic
regimens
containing
or
PTM-targeting
agents
inducers
be
used
overcome
chemotherapeutic
resistance
could
prevent
addition,
highlight
potential
approaches
chemoresistance
halt
