The Pomegranate Flower Water Extract Negatively Regulates Melanogenesis by Suppressing MITF Expression and Its Target Enzymes DOI Creative Commons
Peng Shu, Nannan Xu,

Nuermaimaiti Abudukelimu

et al.

Journal of Cosmetic Dermatology, Journal Year: 2025, Volume and Issue: 24(4)

Published: April 1, 2025

ABSTRACT Background The aesthetic issues caused by pigmentation are increasing people's demand for skin whitening. Considering its long‐term use, it is very important searching safe and effective agents. Pomegranate flower, a kind of traditional Chinese medicine, has shown promising anti‐inflammatory, antioxidant, antidiabetic properties, but potential skin‐lightening effects have not been well explored. Aims We investigated the effect pomegranate flower water extract (PFE) on lightening elucidated underlying mechanisms. Methods radical scavenging capacity was measured ABTS DPPH assays, mechanism detected Western blot. Results PFE could obviously inhibit tyrosinase activity, which inhibition IC 50 value lower than positive control, kojic acid. Meanwhile, also better vitamin C (VC). Then synthesis ability melanin in B16F10 cells; we found that PFE, concentrations, reduce resulting from inhibiting TYR activities. expression main melanogenesis enzymes TYR, TRP‐1, TRP‐2 sharply reduced. Interestingly, MITF, transcription factor decreased when treated with at 50, 100, 150 μg/mL, even significantly downregulation Conclusion possessed strong antimelanogenesis effect, resulted MITF downstream target involved synthesis. These findings provide scientific basis use as ingredient cosmetic industry.

Language: Английский

Signal pathways of melanoma and targeted therapy DOI Creative Commons
Weinan Guo, Huina Wang, Chunying Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2021, Volume and Issue: 6(1)

Published: Dec. 20, 2021

Abstract Melanoma is the most lethal skin cancer that originates from malignant transformation of melanocytes. Although melanoma has long been regarded as a cancerous malignancy with few therapeutic options, increased biological understanding and unprecedented innovations in therapies targeting mutated driver genes immune checkpoints have substantially improved prognosis patients. However, low response rate inevitable occurrence resistance to currently available targeted posed obstacle path management obtain further amelioration. Therefore, it necessary understand mechanisms underlying pathogenesis more comprehensively, which might lead substantial progress approaches expand clinical options for therapy. In this review, we firstly make brief introduction epidemiology, subtypes, risk factors, current therapies. Then, signal pathways orchestrating pathogenesis, including genetic mutations, key transcriptional regulators, epigenetic dysregulations, metabolic reprogramming, crucial metastasis-related signals, tumor-promoting inflammatory pathways, pro-angiogenic systemically reviewed discussed. Subsequently, outline progresses checkpoints, well treatment resistance. Finally, prospects challenges development therapy, especially immunotherapy related ongoing trials, are summarized

Language: Английский

Citations

225
Update on Melasma—Part I: Pathogenesis DOI Creative Commons
Ana Cláudia Cavalcante Espósito, Daniel Pinho Cassiano, Carolina Nunhez da Silva

et al.

Dermatology and Therapy, Journal Year: 2022, Volume and Issue: 12(9), P. 1967 - 1988

Published: July 29, 2022

Melasma is a multifactorial dyschromia that results from exposure to external factors (such as solar radiation) and hormonal sex hormones pregnancy), well skin inflammation contact dermatitis esthetic procedures), in genetically predisposed individuals. Beyond hyperfunctional melanocytes, with melasma exhibits series of structural functional alterations the epidermis, basement membrane, upper dermis interact elicit sustain focal hypermelanogenic phenotype. Evolution knowledge genetic basis cutaneous response radiation, roles endocrine factors, antioxidant system, endothelium proliferation, fibroblast senescence, mast cell degranulation, autophagy deficits melanocyte, paracrine regulation melanogenesis, will lead development new treatments preventive strategies. This review presents current on these aspects pathogenesis discusses effects specific future research issues.

Language: Английский

Citations

60
Melanin Biopolymers in Pharmacology and Medicine—Skin Pigmentation Disorders, Implications for Drug Action, Adverse Effects and Therapy DOI Creative Commons
Marta Karkoszka, Jakub Rok, Dorota Wrześniok

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(4), P. 521 - 521

Published: April 18, 2024

Melanins are biopolymeric pigments formed by a multi-step oxidation process of tyrosine in highly specialized cells called melanocytes. Melanin mainly found the skin, iris, hair follicles, and inner ear. The photoprotective properties melanin biopolymers have been linked to their perinuclear localization protect DNA, but ability scavenge metal ions antioxidant has also noted. Interactions between drugs melanins clinical relevance. formation drug–melanin complexes can affect both efficacy pharmacotherapy occurrence adverse effects such as phototoxic reactions discoloration. Because amount type synthesized body is subject multifactorial regulation—determined internal factors genetic predisposition, inflammation, hormonal balance external contact with allergens or exposure UV radiation—different on melanogenesis be observed. These directly influence skin pigmentation disorders, resulting hypopigmentation hyperpigmentation acquired nature. In this review, we will present information melanocyte biology, melanogenesis, pharmacological parameters during pharmacotherapy. addition, types color special emphasis development, symptoms, methods treatment, presented article.

Language: Английский

Citations

14
Silk fibroin for cosmetic dermatology DOI
Songjie Li, Han Chen,

Xin Dan

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 159986 - 159986

Published: Jan. 1, 2025

Citations

1
PI3K-mediated Kif1a DNA methylation contributes to neuropathic pain: an in vivo study DOI Creative Commons
Wei Jiang, Peng Yu, Yu Yang

et al.

Pain, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 4, 2025

Abstract Neuropathic pain (NP) is a chronic condition caused by nerve injuries, such as compression. Understanding its underlying neurobiological mechanisms critical for developing effective treatments. Previous studies have shown that Kinesin family member 1A ( Kif1a ) heterozygous deficient mice display sensory deficits in response to nociceptive stimuli. PI3K has been found mitigate these enhancing transcription, highlighting KIF1A's key role pain. However, the exact mechanism through which regulates KIF1A expression relation remains unclear. In this study, we observed significant increase PI3K/AKT/CREB (cyclic AMP element-binding protein) protein levels dorsal root ganglia and spinal cord after constriction injury both male female C57BL/6 mice. Notably, elevated of TET1, well mRNA protein, were detected Activated (phosphorylated-CREB) p-CREB recruited DNA demethylase interacted with promoter, reducing methylation increasing expression. inhibition using wortmannin reversed demethylation decreased Furthermore, TET1 knockdown or overexpression significantly affected pain-related behaviors, transcription. Female given intrathecal injections inhibitors exhibited similar molecular behavioral outcomes These findings offer new insights into NP mechanisms, suggesting targeting PI3K/KIF1A axis could be promising therapeutic approach treatment.

Language: Английский

Citations

1
Drug Repurposing of Voglibose, a Diabetes Medication for Skin Health DOI Creative Commons

Hyeonmi Kim,

Chang‐Gu Hyun

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 224 - 224

Published: Feb. 7, 2025

Background/Objectives: Voglibose, an α-glucosidase inhibitor commonly prescribed to manage postprandial hyperglycemia in diabetes mellitus, demonstrates potential for repurposing as anti-melanogenic agent. This study aims explore the inhibitory effects of voglibose on melanogenesis and elucidate its molecular mechanisms, highlighting possible applications treating hyperpigmentation disorders. Methods: The were investigated using B16F10 melanoma cells. Cell viability, melanin content, tyrosinase activity assessed following treatment. Western blot analysis was performed examine changes melanogenic proteins transcription factors. role signaling pathways, including PKA/CREB, MAPK, PI3K/AKT, GSK3β/β-Catenin, analyzed. Primary human skin irritation tests conducted evaluate topical safety voglibose. Results: Voglibose significantly reduced synthesis cells a dose-dependent manner. revealed decreased expression MITF, TRP-1, TRP-2, indicating inhibition melanogenesis. modulated key suppression AKT activation, while restoring GSK3β inhibit β-catenin stabilization. Human confirmed voglibose’s application, showing no adverse reactions at 50 100 μM concentrations. Conclusions: properties through modulation multiple pathways biosynthesis. Its profile efficacy suggest repurposed drug managing advancing cosmeceutical applications.

Language: Английский

Citations

1
Critical Review on Orally Administered Nutricosmetics: Food-Based Solutions Conferring Skin Health from the inside out DOI
Yongxin Ren, Dongcheng Liu, Baojun Xu

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104946 - 104946

Published: Feb. 1, 2025

Language: Английский

Citations

1
mTORC1 activity negatively regulates human hair follicle growth and pigmentation DOI Creative Commons
Takahiro Suzuki, Jérémy Chéret, FERNANDA DINELLI SCALA

et al.

EMBO Reports, Journal Year: 2023, Volume and Issue: 24(7)

Published: May 22, 2023

Abstract Dysregulation of the activity mechanistic target rapamycin complex 1 (mTORC1) is commonly linked to aging, cancer, and genetic disorders such as tuberous sclerosis (TS), a rare neurodevelopmental multisystemic disease characterized by benign tumors, seizures, intellectual disability. Although patches white hair on scalp (poliosis) are considered early signs TS, underlying molecular mechanisms potential involvement mTORC1 in depigmentation remain unclear. Here, we have used healthy, organ‐cultured human follicles (HFs) interrogate role prototypic (mini‐)organ. Gray/white HFs exhibit high activity, while inhibition stimulated HF growth pigmentation, even gray/white that still contained some surviving melanocytes. Mechanistically, this occurred via increased intrafollicular production melanotropic hormone, α‐MSH. In contrast, knockdown TSC2, negative regulator mTORC1, significantly reduced pigmentation. Our findings introduce an important pigmentation suggest pharmacological could become novel strategy management loss disorders.

Language: Английский

Citations

20
Epigenetic Regulation of Ferroptosis in Central Nervous System Diseases DOI
Ting Lan, Ting Sun, Chao Wei

et al.

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(7), P. 3584 - 3599

Published: Feb. 27, 2023

Language: Английский

Citations

18
Skin colour: A window into human phenotypic evolution and environmental adaptation DOI
Jiuming Liu,

Habtom K. Bitsue,

Zhaohui Yang

et al.

Molecular Ecology, Journal Year: 2024, Volume and Issue: 33(12)

Published: May 7, 2024

As modern humans ventured out of Africa and dispersed around the world, they faced novel environmental challenges that led to geographic adaptations including skin colour. Over long history human evolution, colour has changed dramatically, showing tremendous diversity across different geographical regions, for example, majority individuals from expansive lands have darker skin, whereas people Eurasia exhibit lighter skin. What did confer upon as migrated Eurasia? genetic mechanisms underlie observed in populations? In recent years, scientists gradually gained a deeper understanding interactions between pigmentation gene through population-based genomic studies groups particularly East Asia Africa. this review, we summarize our current 26 colour-related genes 48 SNPs influence Important three major populations are described detail: MFSD12, SLC24A5, PDPK1 DDB1/CYB561A3/TMEM138 African populations; OCA2, KITLG, SLC24A2, GNPAT PAH key evolution Asian SLC45A2, TYR, TYRP1, ASIP, MC1R IRF4 significantly contribute lightening European populations. We summarized findings implicate diverse environments, local adaptation among populations, flow multi-gene factors influencing diversity.

Language: Английский

Citations

7