Impaired Iron–Sulfur Cluster Synthesis Induces Mitochondrial PARthanatos in Diabetic Cardiomyopathy DOI Creative Commons
Mengyi Wang, Shiwu Zhang, Jinwei Tian

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 4, 2024

Abstract Diabetic cardiomyopathy (DCM), a severe complication of diabetes, is characterized by mitochondrial dysfunction, oxidative stress, and DNA damage. Despite its severity, the intrinsic factors governing cardiomyocyte damage in DCM remain unclear. It hypothesized that impaired iron–sulfur (Fe–S) cluster synthesis plays crucial role pathogenesis DCM. Reduced S‐sulfhydration cysteine desulfurase (NFS1) novel mechanism contributes to dysfunction PARthanatos Mechanistically, hydrogen sulfide (H 2 S) supplementation restores NFS1 at 383 residue, thereby enhancing Fe–S synthesis, improving function, increasing viability, alleviating cardiac This study provides insights into interplay between clusters, PARthanatos, highlighting promising therapeutic target for paving way potential clinical interventions improve patient outcomes.

Language: Английский

Biomarkers of aging DOI Open Access

Hainan Bao,

Jiani Cao, Mengting Chen

et al.

Science China Life Sciences, Journal Year: 2023, Volume and Issue: 66(5), P. 893 - 1066

Published: April 11, 2023

Language: Английский

Citations

203
Activity-Based Fluorescent Probes for Hydrogen Sulfide and Related Reactive Sulfur Species DOI

Kaylin G. Fosnacht,

Michael D. Pluth

Chemical Reviews, Journal Year: 2024, Volume and Issue: 124(7), P. 4124 - 4257

Published: March 21, 2024

Hydrogen sulfide (H2S) is not only a well-established toxic gas but also an important small molecule bioregulator in all kingdoms of life. In contemporary biology, H2S often classified as "gasotransmitter," meaning that it endogenously produced membrane permeable carries out essential cellular processes. Fluorescent probes for and related reactive sulfur species (RSS) detection provide cornerstone investigating the multifaceted roles these molecules complex biological systems. A now common approach to develop such tools "activity-based probes" couple specific H2S-mediated chemical reaction fluorescent output. This Review covers different types highlights mechanisms by which each probe type activated RSS. Common examples include reduction oxidized nitrogen motifs, disulfide exchange, electrophilic reactions, metal precipitation, coordination. addition, we outline complementary activity-based imaging reductant-labile sulfane species, including persulfides polysulfides. For highlighted this Review, focus on systems with demonstrated compatibility or applications. Building from breadth reported strategies application, highlight key unmet challenges future opportunities advancing

Language: Английский

Citations

68
Implications of hydrogen sulfide in colorectal cancer: Mechanistic insights and diagnostic and therapeutic strategies DOI Creative Commons

Hanchao Lin,

Yixin Yu,

Zhu Le

et al.

Redox Biology, Journal Year: 2023, Volume and Issue: 59, P. 102601 - 102601

Published: Jan. 7, 2023

Hydrogen sulfide (H2S) is an important signaling molecule in colorectal cancer (CRC). It produced the colon by catalytic synthesis of colonocytes' enzymatic systems and release intestinal microbes, oxidatively metabolized mitochondria. Both endogenous H2S colonic epithelial cells exogenous lumen contribute to onset progression CRC. The up-regulation synthetases thought be cause elevated levels CRC cells. Different diagnostic probes combination therapies, as well tumor treatment approaches through modulation, have been developed recent years become active area investigation for diagnosis In this review, we focus on specific mechanisms production oxidative metabolism function occurrence, progression, diagnosis, We also discuss present challenges provide insights into future research burgeoning field.

Language: Английский

Citations

64
Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation DOI Creative Commons

Hui Zhang,

Jianan Pan,

Shuying Huang

et al.

Redox Biology, Journal Year: 2024, Volume and Issue: 70, P. 103066 - 103066

Published: Jan. 29, 2024

Recent studies have demonstrated that ferroptosis, a novel form of nonapoptotic regulated cell death plays an important role in doxorubicin (DOX)-induced cardiotoxicity (DoIC). Hydrogen sulfide (H

Language: Английский

Citations

58
Surface-fill H2S-releasing silk fibroin hydrogel for brain repair through the repression of neuronal pyroptosis DOI Creative Commons

Xueshi Chen,

Xinqi Huang, Chao Liu

et al.

Acta Biomaterialia, Journal Year: 2022, Volume and Issue: 154, P. 259 - 274

Published: Nov. 17, 2022

Traumatic brain injury (TBI) remains the major cause of disability and mortality worldwide due to persistent neuroinflammation neuronal death induced by TBI. Among them, pyroptosis, a specific type programmed cell (PCD) triggered inflammatory signals, plays significant part in pathological process after Inhibition pyroptosis is considered possible strategy for treatment In our previous study, exogenous hydrogen sulfide(H2S) exerted neuroprotective effect Here, we developed surface-fill H2S-releasing silk fibroin (SF) hydrogel (H2S@SF hydrogel) achieve small-dose local administration avoid volatile toxic side effects. We used controlled cortical impact (CCI) establish mild TBI model mice examine H2S@SF on TBI-induced pyroptosis. found that inhibited expression H2S synthase neurons significantly addition, immunofluorescence staining results showed necroptosis protein receptor-interacting serine/threonine-protein kinase 1 (RIPK1) partially colocalized with Gasdermin D (GSDMD) same cells. can also inhibit protein. Moreover, alleviates edema degree neurodegeneration acute phase The was further confirmed wire-grip test, open field Morris water maze, beam balance radial arm tail suspension, forced swimming test. Lastly, measured spared tissue volume, reactive astrocytes activated microglia demonstrate impacts long-term prognosis Our study provides new theoretical basis clinical application hydrogel. STATEMENT OF SIGNIFICANCE: Silk controls release sulfide (H2S) injured tissue. this synthesized hydrogel, which could slowly reshape homeostasis endogenous mouse traumatic injury. Meanwhile, alleviate neurodegeneration, improve motor dysfunction, anxious behavior memory impairment caused TBI, reduce loss ameliorate neuroinflammation.

Language: Английский

Citations

42
S-sulfhydration of SIRT3 combats BMSC senescence and ameliorates osteoporosis via stabilizing heterochromatic and mitochondrial homeostasis DOI Creative Commons
Fei Liu, Longhui Yuan, Lan Li

et al.

Pharmacological Research, Journal Year: 2023, Volume and Issue: 192, P. 106788 - 106788

Published: May 3, 2023

Senescence of bone marrow mesenchymal stem cells (BMSCs) is one the leading causes osteoporosis. SIRT3, an essential NAD-dependent histone deacetylase, highly correlated with BMSC senescence-mediated degradation and mitochondrial/heterochromatic disturbance. S-sulfhydration cysteine residues favorably enhances SIRT3 activity by forming persulfides. Nevertheless, underlying molecular mechanism on homeostasis involved in senescence remains unknown. Here, we demonstrated that CBS CSE, endogenous hydrogen sulfide synthases, are downregulated senescence. Exogenous H2S donor NaHS-mediated augmentation rescued senescent phenotypes BMSCs. Conversely, deletion accelerated oxidative stress-induced through mitochondrial dysfunction detachment heterochromatic protein H3K9me3 from nuclear envelope Lamin B1. H2S-mediated modification disorganized heterochromatin fragmented mitochondria induced inhibitor dithiothreitol, thus to elevated osteogenic capacity preventing The antisenescence effect BMSCs was abolished when CXXC sites zinc finger motif were mutated. In vivo, aged mice-derived pretreated NaHS orthotopically transplanted ovariectomy-induced osteoporotic mice, proved ameliorates loss inhibiting Overall, our study for first time indicates a novel role stabilizing counteracting senescence, providing potential target treatment degenerative diseases.

Language: Английский

Citations

39
Protein persulfidation: Rewiring the hydrogen sulfide signaling in cell stress response DOI
Bo He, Zhe Zhang,

Zhao Huang

et al.

Biochemical Pharmacology, Journal Year: 2023, Volume and Issue: 209, P. 115444 - 115444

Published: Feb. 1, 2023

Language: Английский

Citations

26
Stimuli‐Responsive Organic Near‐Infrared Photoacoustic Probes DOI
Qing Shen, Leichen Wang,

Xiaohong Ruan

et al.

Advanced Functional Materials, Journal Year: 2023, Volume and Issue: 33(21)

Published: Feb. 10, 2023

Abstract Photoacoustic (PA) imaging is an emerging biomedical technique with the features of non‐invasiveness and non‐ionization. It takes advantage photothermal effect PA probes to convert absorbed photon energy into heat subsequent transient thermoelastic tissue expansion for ultrasonic waves images. Thus, exhibits combined superiority high‐contrast optical deep penetration acoustic imaging, which furnishes high‐resolution Stimuli‐responsive organic agents in near‐infrared (NIR) biological window have attracted increasing attention because their low toxicity response characteristics. This review focuses on recent research progress stimuli‐responsive NIR including temperature response, pH redox metal ion enzyme response. And mechanisms are highlighted detail. Moreover, perspectives challenges discussed. will be great help further development stimuli‐response.

Language: Английский

Citations

24
The Role of Hydrogen Sulfide (H2S) in Epigenetic Regulation of Neurodegenerative Diseases: A Systematic Review DOI Open Access

Bombonica Gabriela Dogaru,

Constantin Munteanu

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(16), P. 12555 - 12555

Published: Aug. 8, 2023

This review explores the emerging role of hydrogen sulfide (H

Language: Английский

Citations

21
The role of deubiquitinases in cardiac disease DOI Creative Commons

Xiaona Zhan,

Yi Won Yang,

Qing Li

et al.

Expert Reviews in Molecular Medicine, Journal Year: 2024, Volume and Issue: 26

Published: Jan. 1, 2024

Abstract Deubiquitinases are a group of proteins that identify and digest monoubiquitin chains or polyubiquitin attached to substrate proteins, preventing the protein from being degraded by ubiquitin-proteasome system. regulate cellular autophagy, metabolism oxidative stress acting on different proteins. Recent studies have revealed deubiquitinases act as critical regulator in various cardiac diseases, control onset progression disease through board range mechanism. This review summarizes function disease, including hypertrophy, myocardial infarction diabetes mellitus-related disease. Besides, this briefly recapitulates role modulators providing potential therapeutic targets future.

Language: Английский

Citations

7