Implications of endoplasmic reticulum stress and autophagy in aging and cardiovascular diseases DOI Creative Commons
Chenguang Ma, Yang Liu, Zhiling Fu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 25, 2024

The average lifespan of humans has been increasing, resulting in a rapidly rising percentage older individuals and high morbidity aging-associated diseases, especially cardiovascular diseases (CVDs). Diverse intracellular extracellular factors that interrupt homeostatic functions the endoplasmic reticulum (ER) induce ER stress. Cells employ dynamic signaling pathway unfolded protein response (UPR) to buffer Recent studies have demonstrated stress triggers various cellular processes associated with aging many including CVDs. Autophagy is conserved process involving lysosomal degradation recycling cytoplasmic components, proteins, organelles, pathogens invade cytoplasm. vital for combating adverse influence on heart. present report summarizes recent mechanism autophagy their overlap CVD pathogenesis context aging. It also discusses possible therapeutic interventions targeting might delay prevent or treat

Language: Английский

“Copper-Loaded Microplastics Unleash Endoplasmic Reticulum Stress-driven Liver Apoptosis in Fish Channa punctatus” DOI Creative Commons

Jumman Bakhasha,

Vaishnavi Saxena,

Neeti Arya

et al.

Emerging contaminants, Journal Year: 2024, Volume and Issue: 11(1), P. 100422 - 100422

Published: Oct. 9, 2024

Language: Английский

Citations

3
Dietary bitter ginger-derived zerumbone improved memory performance during aging through inhibition of the PERK/CHOP-dependent endoplasmic reticulum stress pathway DOI
Chuan Yang,

Meihuan Zhao,

Yuanyuan Chen

et al.

Food & Function, Journal Year: 2024, Volume and Issue: 15(18), P. 9070 - 9084

Published: Jan. 1, 2024

PERK/CHOP pathway-mediated excessive endoplasmic reticulum (ER) stress is closely linked to aging-related cognitive impairment (ARCD). Zerumbone (ZB), a naturally occurring sesquiterpene molecule obtained from dietary bitter ginger, has garnered significant interest due its diverse range of biological properties. It unclear, though, if ZB can reduce ARCD by preventing ER that dependent on the pathway. Here, PERK-CHOP pathway was main focus an evaluation effects and mechanisms for attenuating in D-galactose (D-gal)-induced aging mice SH-SY5Y cells. According our findings, not only greatly decreased neuronal both

Language: Английский

Citations

2
SERCA2 protects against cisplatin-induced damage of auditory cells: Possible relation with alleviation of ER stress DOI

Yue Xu,

Hao Zhao, Fan Wang

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 486, P. 116947 - 116947

Published: April 28, 2024

Language: Английский

Citations

1
Expression of ITPR2 regulated by lncRNA-NONMMUT020270.2 in LPS-stimulated HT22 cells DOI Creative Commons
Lan Liu, Liang Tang, Yan Wang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(13), P. e33491 - e33491

Published: June 25, 2024

Language: Английский

Citations

1
Implications of endoplasmic reticulum stress and autophagy in aging and cardiovascular diseases DOI Creative Commons
Chenguang Ma, Yang Liu, Zhiling Fu

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: July 25, 2024

The average lifespan of humans has been increasing, resulting in a rapidly rising percentage older individuals and high morbidity aging-associated diseases, especially cardiovascular diseases (CVDs). Diverse intracellular extracellular factors that interrupt homeostatic functions the endoplasmic reticulum (ER) induce ER stress. Cells employ dynamic signaling pathway unfolded protein response (UPR) to buffer Recent studies have demonstrated stress triggers various cellular processes associated with aging many including CVDs. Autophagy is conserved process involving lysosomal degradation recycling cytoplasmic components, proteins, organelles, pathogens invade cytoplasm. vital for combating adverse influence on heart. present report summarizes recent mechanism autophagy their overlap CVD pathogenesis context aging. It also discusses possible therapeutic interventions targeting might delay prevent or treat

Language: Английский

Citations

1