Periodontal Indices as Predictors of Cognitive Decline: Insights from the PerioMind Colombia Cohort

Biomedicines, Journal Year: 2025, Volume and Issue: 13(1), P. 205 - 205

Published: Jan. 15, 2025

Background: Poor oral health and periodontitis have been epidemiologically linked to cognitive decline mild impairment (MCI) in older adults. However, specific metrics directly linking these clinical signs are exceedingly limited. Methods: To address this gap develop novel tools help clinicians identify individuals at risk of decline, we established the PerioMind Colombia Cohort, comprising elderly Colombian subjects who underwent comprehensive neurocognitive periodontal evaluations. Results: The results revealed that diagnosed with MCI exhibited significantly higher scores indices, including gingival erythema pocket depth parameters. predictive model identified positive associations MCI, showing strongest correlation, followed by presence variations measurements. Additionally, lower educational attainment was associated a likelihood being classified periodontitis-MCI group. Conclusions: Here, show altered diagnosis, generated provide defined metric ranges for identifying risk. Upon validation larger cohorts, findings reported here could offer dental practitioners innovative age-related dementias through routine assessments, thereby enabling more accessible highly sought-after early intervention strategies both developing developed countries.

Language: Английский

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Exploring Advancements in Early Detection of Alzheimer's Disease with Molecular Assays and Animal Models

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102411 - 102411

Published: July 9, 2024

Language: Английский

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Mechanisms, consequences and role of interventions for sleep deprivation: Focus on mild cognitive impairment and Alzheimer’s disease in elderly

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 100, P. 102457 - 102457

Published: Aug. 17, 2024

Language: Английский

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Serotonin in Depression and Alzheimer’s Disease: Focus on SSRI’s Beneficial Effects

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102537 - 102537

Published: Oct. 9, 2024

Language: Английский

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Improved deep canonical correlation fusion approach for detection of early mild cognitive impairment

Medical & Biological Engineering & Computing, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 14, 2025

Language: Английский

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Role of OX/OXR cascade in insomnia and sleep deprivation link Alzheimer’s disease and Parkinson’s disease: Therapeutic avenue of Dual OXR Antagonist (DORA)

Biochemical Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 116794 - 116794

Published: Feb. 1, 2025

Language: Английский

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Cognitive vascular disorders and morphometric parameters of the prefrontal, dorsolateral cortex and thalamus in post-stroke patients

S S Korsakov Journal of Neurology and Psychiatry, Journal Year: 2025, Volume and Issue: 125(2), P. 91 - 91

Published: March 6, 2025

To assess the relationship between size of prefrontal, dorsolateral cortex and thalamus according to brain CT scans cognitive functions in patients early recovery period cerebral ischemic stroke. One hundred two (67.6% males) stroke were examined using a short scale mental status Montreal function morphometry performed acute The mean age was 63 years [59; 69.75]. Obtained data indicate statistically significant direct association thickness bilaterally preservation. not associated with functioning assessed sizes studied directly related functions, on both sides correlation health indicators.

Language: Английский

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Effect of knockdown LncRNA SNHG1 on autophagic function in SH-SY5Y cells: a model of Alzheimer’s disease (AD)

Journal of Toxicology and Environmental Health, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: March 5, 2025

Alzheimer 's disease, a neurodegenerative is considered serious global type of dementia affecting predominantly elderly associated with progressive memory loss. disease exhibits typical pathological manifestations including neuronal loss, β-amyloid deposition, and tau protein neurofibrillary tangles. Significantly increased expression long-non -coding transcript RNA, LncRNA SNHG1, was detected in the brain AD patients. However, it not clear whether knockdown SNHG1 might improve autophagy function SH-SY5Y cells reduce number apoptotic cells. The aim this study to (1) examine role on autophagic following induction by Aβ1-42 (2) elucidate underlying mechanisms. were transfected lentiviral vectors construct cell line stable genetic ability knock down compared control empty vector line. Following for 24 hr, an model constructed. Downregulation significantly viability lowered Concomitantly downregulation induced significant decrease p-tau caspase3 elevated Beclin1 AMBRA1. Our results showed that reduced enhancing Data suggest knocking may be potential target compounds treat AD.

Language: Английский

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From biomarkers to brain imaging: Refining early diagnosis of mild cognitive impairment

Journal of Clinical Neuroscience, Journal Year: 2025, Volume and Issue: unknown, P. 111187 - 111187

Published: March 1, 2025

Language: Английский

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A randomized, controlled trial to evaluate the efficacy of pyridoxine and ascorbic acid on cognitive function and quality of life in post-menopausal women

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: April 29, 2025

Language: Английский

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