Implications of serum calcitonin gene-related peptide and type I interferon in systemic lupus erythematosus-associated headaches DOI
Shu Sugimoto, Yasuhiro Shimojima, Dai Kishida

et al.

Lupus, Journal Year: 2025, Volume and Issue: unknown

Published: April 3, 2025

Objective Headache is a common neurological symptom in patients with systemic lupus erythematosus (SLE). Calcitonin gene-related peptide (CGRP) potential chemical mediator of headaches, while type I interferon (IFN) plays pivotal role the immune system SLE. This study investigated implications CGRP and IFNs as headache biomarkers Methods We used clinical information serum samples from 144 SLE Japanese multicenter cohort biobank. Serum CGRP, IFN-α, IFN-β levels, which were measured using enzyme-linked immunoassay, compared among headache, those without 20 healthy controls (HC). These levels based on severity daily disability caused by headaches determined Migraine Disability Assessment. Results Of patients, 60 had (median age, 42 years; 56 women) significantly younger than 49 77 ( p < .005). Both groups median Disease Activity Index 2000 score 4.0, was not different, whereas photosensitivity more prevalent .05). IFN-α different between HC. higher .005), being lower both HC No significant differences observed related to headaches. Conclusion may be involved SLE-associated

Language: Английский

Revisiting Childhood-Onset Systemic Lupus Erythematosus DOI Creative Commons
Pınar Özge Avar-Aydın, Hermine I. Brunner

Turkish Archives of Pediatrics, Journal Year: 2024, Volume and Issue: 59(4), P. 336 - 344

Published: Aug. 2, 2024

Childhood-onset systemic lupus erythematosus (cSLE) is a chronic autoimmune disease with multisystemic involvement diagnosed during childhood. The marked by the production of autoantibodies targeting self-antigens, often before symptoms emerge. presentation, clinical course, and outcome vary significantly among patients cSLE. onset cSLE can be at any age childhood while diagnosis 5 years rare raises suspicion monogenic lupus. affects various organs systems, most frequently presenting mucocutaneous, musculoskeletal, renal, neuropsychiatric manifestations. Multiple flares seen course. causes significant morbidity mortality. Children adolescents show higher activity damage, more aggressive immunosuppressive treatments are needed compared to adultonset SLE. Early difficult due insidious nonspecific symptoms. Disease damage measures aim ensure an accurate evaluation status. A multidisciplinary approach individualized management important. complex including control activity, reduction limitation drug toxicity improving health-related quality life in

Language: Английский

Citations

10
Systemic lupus erythematosus in childhood and adolescence DOI
Ekemini A. Ogbu, Hermine I. Brunner,

Lisa F. Imundo

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 580 - 595

Published: April 12, 2024

Language: Английский

Citations

9
Prevalence and identification of neuropsychiatric symptoms in systemic autoimmune rheumatic diseases: an international mixed methods study DOI Creative Commons
Melanie Sloan, Chris Wincup, Rupert Harwood

et al.

Lara D. Veeken, Journal Year: 2023, Volume and Issue: 63(5), P. 1259 - 1272

Published: July 26, 2023

A limited range of neuropsychiatric symptoms have been reported in systemic autoimmune rheumatic diseases (SARDs), with varied symptom prevalence. This study aimed to investigate a wider potential than previous studies, compare patient self-reports clinician estimates, and explore barriers identification.

Language: Английский

Citations

19
Neuropsychiatric involvement in juvenile-onset systemic lupus erythematosus: A multicenter study DOI
Ayşenur Paç Kısaarslan, Sümeyra Özdemir Çiçek, Ezgi Deniz Batu

et al.

Joint Bone Spine, Journal Year: 2023, Volume and Issue: 90(4), P. 105559 - 105559

Published: Feb. 28, 2023

Language: Английский

Citations

17
Predictive factors of psychiatric syndrome in patients with systemic lupus erythematosus DOI Creative Commons
Wenqi Geng,

Shangzhu Zhang,

Jinya Cao

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: March 21, 2024

Introduction Early detection of neuropsychiatric systemic lupus erythematosus (NPSLE) remains a challenge in clinical settings. Previous studies have found different autoantibodies as markers for NPSLE. This study aimed to describe the distribution psychiatric syndromes group patients with (SLE) and investigate association between specific autoantibodies. Methods retrospective was conducted at single medical center China. We reviewed records hospitalized SLE who were consulted by psychiatrists due potential mental disorders. Results serum general laboratory tests collected. The correlation variables examined. Binary logistic regression analyses used determine factors related NPSLE diagnoses. Among 171 manifestations 160 patients, 141 (82.4%) attributed SLE. Acute confusional state (ACS) had highest prevalence (57.4%). Anti-cardiolipin (ACL) antibody ( X 2 = 142.261, p &lt; 0.001) anti-β2 glycoprotein I (-β2GP1) 139.818, varied significantly groups, positive rate mood disorders (27.3% 18.2%). disease activity index – 2000 (SLEDAI-2K) score excluding item ACS psychosis predictor (OR 1.172 [95% CI 1.105 - 1.243]). Conclusions Disease reflected SLEDAI-2K is Antiphospholipid antibodies are associated Further separate investigation needed order better comprehend NPSLE’s pathological mechanism.

Language: Английский

Citations

7
The Challenge of Neuropsychiatric Systemic Lupus Erythematosus: From Symptoms to Therapeutic Strategies DOI Creative Commons
Veena Patel

Diagnostics, Journal Year: 2024, Volume and Issue: 14(11), P. 1186 - 1186

Published: June 5, 2024

Systemic lupus erythematosus (SLE) is a chronic autoimmune condition that can seriously impair multiple organs including the nervous system, causing neuropsychiatric SLE (NPSLE), which encompasses broad range of symptoms. Pathogenesis not completely understood but thought to involve inflammatory and vascular pathways. This comprehensive review discusses complex nature heterogeneity NPSLE challenges in diagnosis treatment result from it. Diagnosis often requires multidisciplinary approach with assessments, laboratory testing, imaging, neuropsychological evaluations. Current treatments focus on managing symptoms through immunosuppressive anti-thrombotic therapies tailored or specific manifestations. paper emphasizes necessity for interdisciplinary approaches further research enhance diagnostic accuracy effectiveness. It also highlights importance understanding underlying mechanisms develop more targeted therapies, citing need high-quality studies novel agents.

Language: Английский

Citations

6
Headache and immunological/autoimmune disorders: a comprehensive review of available epidemiological evidence with insights on potential underlying mechanisms DOI Creative Commons
Leonardo Biscetti,

Gioacchino De Vanna,

Elena Cresta

et al.

Journal of Neuroinflammation, Journal Year: 2021, Volume and Issue: 18(1)

Published: Nov. 8, 2021

Abstract Several lines of evidence support a role the immune system in headache pathogenesis, with particular regard to migraine. Firstly, alterations cytokine profile and lymphocyte subsets have been reported patients. Secondly, several genetic environmental pathogenic factors seem be frequently shared by immunological/autoimmune diseases. Accordingly, immunological primary headaches, migraine, suggested predispose some patients development autoimmune On other hand, mechanisms underlying disorders, cases, favour onset headache. Therefore, an association between disorders has thoroughly investigated last years. The knowledge this possible may relevant implications clinical practice when deciding diagnostic therapeutic approaches. present review summarizes findings date regarding plausible relationship starting from description alteration moving onward supporting potential link each specific autoimmune/immunological disease.

Language: Английский

Citations

39
Prevalence of anxiety, depression, sleeping problems, cognitive impairment, and suicidal ideation in people with autoimmune skin diseases DOI

Yi‐Jie Jia,

Peng Liu, Jie Zhang

et al.

Journal of Psychiatric Research, Journal Year: 2024, Volume and Issue: 176, P. 311 - 324

Published: June 16, 2024

Language: Английский

Citations

5
Emergencies in inflammatory rheumatic diseases DOI Creative Commons
Dana Auyezkhankyzy, Aigulsum Izekenova, Burhan Fatih Koçyiğit

et al.

Rheumatology International, Journal Year: 2024, Volume and Issue: 44(9), P. 1637 - 1646

Published: July 9, 2024

Inflammatory rheumatic diseases (IRDs), encompassing a broad spectrum of chronic disorders, typically necessitate prolonged therapeutic intervention. Nevertheless, these can sometimes manifest as severe emergencies requiring prompt and extensive medical Urgent intervention is essential for effectively recognizing managing situations, they have the potential to be life-threatening result in morbidity mortality. Emergencies IRDs occur with different frequencies manifestations, including nervous system issues, infections, thrombosis-emboli, renal crises, gastrointestinal cardiovascular events. The fact that events across underscores necessity heightened awareness readiness among healthcare professionals. pathophysiologic mechanisms cause are complex involve multiple factors. These frequently arise due interplay between inflammatory characteristics systemic triggers. Early detection treatment substantial impact on an individual's prognosis cases disorders require recognition. Rapid decision-making urgent care required address emergencies, well implementation diagnostic flowchart. This article provides overview linked IRDs, classifying assessing them individually. aims enhance professionals' knowledge critical situations by examining current recommendations pathophysiological information. Implementing standardized methods, providing patient education, conducting continuing research into underlying enhancing management improving outcomes.

Language: Английский

Citations

4
Attribution of psychiatric manifestations to systemic lupus erythematosus in Chinese patients: A retrospective study DOI
Wenqi Geng,

Xiaoxi Yang,

Jinya Cao

et al.

World Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 15(2)

Published: Jan. 14, 2025

BACKGROUND Not all neuropsychiatric (NP) manifestations in patients with systemic lupus erythematosus (SLE) are secondary to lupus. The clarification of the cause NP symptoms influences therapeutic strategies for SLE. AIM To understand attribution psychiatric a cohort Chinese METHODS This retrospective single-center study analyzed 160 inpatient medical records. Clinical diagnosis, which is considered gold standard, was used divide subjects into SLE (PSLE) group (G1) and (G2). features were compared between these two groups. sensitivity specificity Italian model explored. RESULTS A total 171 syndromes recorded 138 patients, including 87 cases acute confusional state, 40 cognitive dysfunction, 18 psychosis, 13 each depressive disorder mania or hypomania. 141 (82.5%) attributed In contrast G2 G1 had higher Disease Activity Index-2000 scores (21 vs 12, P = 0.001), lower prevalence anti-beta-2-glycoprotein 1 antibodies (8.6% 25.9%, 0.036), anti-ribosomal ribonucleoprotein particle (rRNP) (39.0% 22.2%, 0.045). exhibited 95.0% 70.0% when threshold value set at 7. CONCLUSION Patients PSLE increased disease activity. There correlation anti-rRNP antibodies. effectively assesses multiple who present symptoms.

Language: Английский

Citations

0