Study of tumor necrosis factor receptor in the inflammatory bowel disease

World Journal of Gastroenterology, Journal Year: 2023, Volume and Issue: 29(18), P. 2733 - 2746

Published: May 10, 2023

Ulcerative colitis (UC) and Crohn's disease (CD) are part of Inflammatory Bowel Diseases (IBD) have pathophysiological processes such as bowel necrosis enteric neurons glial cells. In addition, the main inflammatory mediator is related to tumor factor-alpha (TNF-α). TNF-α a me-diator intestinal processes, thus being one cytokines involved in pathogenesis IBD, however, its levels, when measured, present serum patients with IBD. plays an important role promoting inflammation, production interleukins (IL), for instance IL-1β IL-6. There two receptors TNF following: The factor 1 receptor (TNFR1); 2 (TNFR2). They IBD their been detected expression correlated activity. soluble form binds TNFR1 with, activation results signaling cascade effects apoptosis, cell proliferation cytokine secretion. contrast, transmembrane can bind both TNFR2. Recent studies suggested that pro-inflammatory since levels UC CD. Intravenous subcutaneous biologics targeting revolutionized treatment becoming best available agents induce maintain remission. application antibodies aimed at neutralizing satisfactory clinical response up 60% patients, also induced long-term maintenance remission most patients. It has anti-TNF-α inactivate by direct neutralization, i.e., resulting suppression inflammation. However, perform more complex functions than simple blockade.

Language: Английский

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Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota

Journal of Ethnopharmacology, Journal Year: 2024, Volume and Issue: 328, P. 117956 - 117956

Published: Feb. 29, 2024

Language: Английский

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Health benefits of algae and marine-derived bioactive metabolites for modulating ulcerative colitis symptoms

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 125, P. 106690 - 106690

Published: Jan. 28, 2025

Language: Английский

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Immunohistochemistry Analysis in Inflammatory Bowel Disease—Should We Bring to Light Interleukin-10?

Biomedicines, Journal Year: 2025, Volume and Issue: 13(2), P. 406 - 406

Published: Feb. 7, 2025

Background/Objectives: Inflammatory bowel diseases (IBDs) are chronic intestinal disorders with an unpredictable course. In parallel the advent of new biologic therapies targeting specific interleukin pathways, end-point targets have become more stringent, aiming for mucosal and even histologic healing. Methods: We conducted a prospective study assessing immunohistochemical (IHC) parameters in 46 IBD patients treated therapy. A similar IHC analysis was performed comparison cohort 10 "non-IBD" patients. Results: The highest integrated optical density (IOD) TNF-α observed dysplasia, abscesses, mucin depletion basal plasmacytosis. Non-responders had higher pre- post-treatment expression both UC CD compared to responders. On contrary, same subpopulation anti-TNF-α therapy (Infliximab Adalimumab) did not reveal substantial difference between responders non-responders. High pre-treatment interleukin-10 associated failure, histological inflammatory activity longer disease duration. Conclusions: Pre-treatment assessment IL-10 might be useful tool identifying high-risk subset determining aggressive intensive monitoring strategy.

Language: Английский

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Microencapsulation and Probiotic Characterization of Lactiplantibacillus plantarum LM-20: Therapeutic Application in a Murine Model of Ulcerative Colitis

Nutrients, Journal Year: 2025, Volume and Issue: 17(5), P. 749 - 749

Published: Feb. 20, 2025

Background: Microencapsulation improves the storage, handling, and administration of probiotics by protecting them from environmental factors adverse conditions in gastrointestinal tract. This process facilitates their controlled delivery body, which can simplify use therapies without compromising therapeutic efficacy. Objectives: study investigates microencapsulation Lactiplantibacillus plantarum LM-20, its probiotic properties, effects a murine model ulcerative colitis. Methods/Results: Synbiotic was carried out using spray drying with maltodextrin, gum Arabic, inulin, achieving an encapsulation efficiency 90.76%. The resulting microcapsules exhibited remarkable resistance to simulated vitro, maintaining survival rate 90%. did not compromise characteristics bacteria, as they demonstrated enhanced auto-aggregation, hydrophobicity, phenol tolerance. potential microencapsulated synbiotic evaluated dextran sodium sulfate-induced results revealed that mice treated LM-20 showed 83.3% reduction disease activity index (DAI) compared colitis control group. Moreover, significant decrease observed pro-inflammatory cytokine levels (IL-1β TNF-α) myeloperoxidase activity, values comparable those healthy Conclusions: These findings suggest could be promising candidate for applications prevention management

Language: Английский

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Dynamic Changes in Gut Microbiome of Ulcerative Colitis: Initial Study from Animal Model

Journal of Inflammation Research, Journal Year: 2022, Volume and Issue: Volume 15, P. 2631 - 2647

Published: April 1, 2022

Background: An animal model of DSS-induced UC has been widely used in basic research, and the dysbiosis gut microbiome is one important pathogenetic mechanisms UC, but its dynamic changes correlation with inflammatory factors are not clear yet. Methods: Clinical signs tissue damage degree C57BL/6 ulcerative colitis mice induced by different concentrations DSS were compared that normal mice, finally optimal concentration was determined. Then we analyzed sequencing results to determine patterns their factors. Results: at 2.5% 3.0% could cause intestinal injury induce colitis. However, resulted higher mortality. In addition, there model: relative abundance flora increased first then decreased Bacteroides , Parabacteroides Romboutsia Clostridium_sensu_stricto_1, Lachnospiraceae_NK4A136_group, norank_f_norank_o_Clostridia_UCG-014, Parasutterella Lactobacillus Muribaculum norank_f_Muribaculaceae, Bifidobacterium Coriobacteriaceae_UCG-002 Enterorhabdus did change 14 days significantly on day 21. Moreover, cytokines closely associated imbalance microbiota UC: most pathogenic bacteria tract positively correlated pro-inflammatory negatively anti-inflammatory factors, while beneficial opposite. Conclusion: Intestinal microecology plays an role model, dynamically occurrence development Keywords: colitis, DSS, microbiome, changes, 16S rDNA

Language: Английский

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Extracellular Vesicles: The Next Generation Theranostic Nanomedicine for Inflammatory Bowel Disease

International Journal of Nanomedicine, Journal Year: 2022, Volume and Issue: Volume 17, P. 3893 - 3911

Published: Sept. 1, 2022

Abstract: The recent rapid development in the field of extracellular vesicles (EVs) based nanotechnology has provided unprecedented opportunities for nanomedicine platforms. As natural nanocarriers, EVs such as exosomes, exosome-like nanoparticles and outer membrane (OMVs), have unique structure/composition/morphology characteristics, show excellent physical chemical/biochemical properties, making them a new generation theranostic nanomedicine. Here, we reviewed characteristics from perspective their formation biological function inflammatory bowel disease (IBD). Moreover, can crucially participate interaction communication intestinal epithelial cells (IECs)-immune cells-gut microbiota to regulate immune response, inflammation homeostasis. Interestingly, on current representative examples exosomes IBD treatment, it is shown that plant, milk, cells-derived exert therapeutic effect through components, proteins, nucleic acid, lipids. several drug loading methods target modification are used improve capability. We also discussed application treatment IBD. In this review, aim better more clearly clarify underlying mechanisms pathogenesis IBD, provide directions mediated treatment. Keywords: vesicles, exosome, nanoparticles, disease,

Language: Английский

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Recent updates on correlation between reactive oxygen species and synbiotics for effective management of ulcerative colitis

Frontiers in Nutrition, Journal Year: 2023, Volume and Issue: 10

Published: July 20, 2023

Ulcerative colitis (UC) is presently considered a multifactorial pathology, which may lead to persistent inflammatory action of the gastrointestinal tract (GIT) because an improperly managed immunological reactivity intestinal microbiota found in GIT. The immune response common commensal microbes plays essential role inflammation related UC synbiotics, and it important element optimal therapy UC. Therefore, i.e., mixture prebiotics probiotics, help control diseased state. Synbiotics alleviate colon by lowering reactive oxygen species (ROS) improving level antioxidant enzymes such as catalase (CAT), glutathione peroxidase (GPX), superoxide dismutase (SOD). Prebiotic supplementation not practice at moment, despite numerous research findings proving that benefits both probiotics encourage their continued existence positioning GIT, with positive effects on human health managing response. However, fact there have been fewer studies treatment different coupled selected prebiotics, outcomes these very favorable. This evidence-based study explores possible ROS, SOD, synbiotics proposed review also focuses alteration gut microbiota, defense tract, management Thus, current article emphasizes oxidative stress signaling GI stress-based pathomechanisms patients, therapies inhibiting stress’ effects.

Language: Английский

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Effects of four food hydrocolloids on colitis and their regulatory effect on gut microbiota

Carbohydrate Polymers, Journal Year: 2023, Volume and Issue: 323, P. 121368 - 121368

Published: Sept. 9, 2023

Language: Английский

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Taurohyodeoxycholic acid alleviates trinitrobenzene sulfonic acid induced ulcerative colitis via regulating Th1/Th2 and Th17/Treg cells balance

Life Sciences, Journal Year: 2023, Volume and Issue: 318, P. 121501 - 121501

Published: Feb. 15, 2023

Language: Английский

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